Functional Characterization of Iron-Substituted Tristetraprolin-2D (TTP-2D, NUP475-2D):  RNA Binding Affinity and Selectivity

The protein tristetraprolin (TTP, also known as NUP475 and TIS11) is a nonclassical zinc finger protein that is involved in regulating the inflammatory response. Specifically, TTP binds to AU-rich sequence elements located at the 3‘-untranslated region of cytokine mRNAs forming a complex that is deg...

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Veröffentlicht in:	Biochemistry (Easton) 2006-11, Vol.45 (45), p.13641-13649
Hauptverfasser:	diTargiani, Robert C, Lee, Seung Jae, Wassink, Sarah, Michel, Sarah L. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anisotropy Base Sequence Cloning, Molecular Cobalt - metabolism Escherichia coli Ferric Compounds - metabolism Ferrous Compounds - metabolism Iron - metabolism Mice RNA, Messenger - metabolism Spectrophotometry Tristetraprolin - chemistry Tristetraprolin - metabolism Zinc - metabolism
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