Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera
Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neur...
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| Veröffentlicht in: | The Journal of infectious diseases 2007-09, Vol.196 (5), p.709-711 |
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| container_title | The Journal of infectious diseases |
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| creator | Verma, Susama Cikurel, Katia Koralnik, Igor J. Morgello, Susan Cunningham-Rundles, Charlotte Weinstein, Zelig R. Bergmann, Christine Simpson, David M. |
| description | Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML. |
| doi_str_mv | 10.1086/520514 |
| format | Article |
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We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/520514</identifier><identifier>PMID: 17674313</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>AIDS ; Biological and medical sciences ; Female ; Fundamental and applied biological sciences. Psychology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; JC virus ; Lesions ; Leukoencephalopathies ; Leukoencephalopathy, Progressive Multifocal - complications ; Leukoencephalopathy, Progressive Multifocal - drug therapy ; Leukoencephalopathy, Progressive Multifocal - pathology ; Medical sciences ; Mianserin - analogs & derivatives ; Mianserin - therapeutic use ; Microbiology ; Middle Aged ; Miscellaneous ; Neuroglia ; Polycythemia Vera - complications ; Polycythemia Vera - pathology ; Progressive multifocal leukoencephalopathy ; Receptors ; Serotonin Uptake Inhibitors - therapeutic use ; T lymphocytes ; Viral diseases ; Viral diseases of the nervous system ; Virology ; Viruses ; White matter</subject><ispartof>The Journal of infectious diseases, 2007-09, Vol.196 (5), p.709-711</ispartof><rights>Copyright 2007 Infectious Diseases Society of America</rights><rights>2007 by the Infectious Diseases Society of America 2007</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-3c0654cd560bbf00a1b4866a3f9cec474ede49e98d2f5e2e319f8b33173826033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086679$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086679$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19020993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17674313$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verma, Susama</creatorcontrib><creatorcontrib>Cikurel, Katia</creatorcontrib><creatorcontrib>Koralnik, Igor J.</creatorcontrib><creatorcontrib>Morgello, Susan</creatorcontrib><creatorcontrib>Cunningham-Rundles, Charlotte</creatorcontrib><creatorcontrib>Weinstein, Zelig R.</creatorcontrib><creatorcontrib>Bergmann, Christine</creatorcontrib><creatorcontrib>Simpson, David M.</creatorcontrib><title>Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.</description><subject>AIDS</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>JC virus</subject><subject>Lesions</subject><subject>Leukoencephalopathies</subject><subject>Leukoencephalopathy, Progressive Multifocal - complications</subject><subject>Leukoencephalopathy, Progressive Multifocal - drug therapy</subject><subject>Leukoencephalopathy, Progressive Multifocal - pathology</subject><subject>Medical sciences</subject><subject>Mianserin - analogs & derivatives</subject><subject>Mianserin - therapeutic use</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Neuroglia</subject><subject>Polycythemia Vera - complications</subject><subject>Polycythemia Vera - pathology</subject><subject>Progressive multifocal leukoencephalopathy</subject><subject>Receptors</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>T lymphocytes</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><subject>Virology</subject><subject>Viruses</subject><subject>White matter</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MFu1DAQBmALgehS4A1A6aHcUsaxY8fHqqItaFsqARWCg-U4E9ZtNg62A2yfvqmyarkgTnP4P81ofkJeUjigUIm3ZQEl5Y_IgpZM5kJQ9pgsAIoip5VSO-RZjFcAwJmQT8kOlUJyRtmCfD9zIZkbM7geM9dnF8H_CBij-4XZ2dgl13prumyJ47XH3uKwMp0fTFptssMYvXUmYZP9dmmVXfhuYzdphWtnsksM5jl50pou4ovt3CVfjt99PjrNlx9P3h8dLnPLC55yZkGU3DalgLpuAQyteSWEYa2yaLnk2CBXqKqmaEsskFHVVjVjVLKqEMDYLnkz7x2C_zliTHrtosWuMz36MWpRUaqEkP-FBTChqPwL2uBjDNjqIbi1CRtNQd_1ree-J_h6u3Gs19g8sG3BE9jfAhOnIttgeuvig1NQgFJ3bm92fhz-fezVbK5i8uFeMZiMkGrK8zl3MeGf-9yEaz09L0t9-vWbpuel-PDphOpLdgsARaot</recordid><startdate>20070901</startdate><enddate>20070901</enddate><creator>Verma, Susama</creator><creator>Cikurel, Katia</creator><creator>Koralnik, Igor J.</creator><creator>Morgello, Susan</creator><creator>Cunningham-Rundles, Charlotte</creator><creator>Weinstein, Zelig R.</creator><creator>Bergmann, Christine</creator><creator>Simpson, David M.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20070901</creationdate><title>Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera</title><author>Verma, Susama ; Cikurel, Katia ; Koralnik, Igor J. ; Morgello, Susan ; Cunningham-Rundles, Charlotte ; Weinstein, Zelig R. ; Bergmann, Christine ; Simpson, David M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-3c0654cd560bbf00a1b4866a3f9cec474ede49e98d2f5e2e319f8b33173826033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>AIDS</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>JC virus</topic><topic>Lesions</topic><topic>Leukoencephalopathies</topic><topic>Leukoencephalopathy, Progressive Multifocal - complications</topic><topic>Leukoencephalopathy, Progressive Multifocal - drug therapy</topic><topic>Leukoencephalopathy, Progressive Multifocal - pathology</topic><topic>Medical sciences</topic><topic>Mianserin - analogs & derivatives</topic><topic>Mianserin - therapeutic use</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Neuroglia</topic><topic>Polycythemia Vera - complications</topic><topic>Polycythemia Vera - pathology</topic><topic>Progressive multifocal leukoencephalopathy</topic><topic>Receptors</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>T lymphocytes</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><topic>Virology</topic><topic>Viruses</topic><topic>White matter</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verma, Susama</creatorcontrib><creatorcontrib>Cikurel, Katia</creatorcontrib><creatorcontrib>Koralnik, Igor J.</creatorcontrib><creatorcontrib>Morgello, Susan</creatorcontrib><creatorcontrib>Cunningham-Rundles, Charlotte</creatorcontrib><creatorcontrib>Weinstein, Zelig R.</creatorcontrib><creatorcontrib>Bergmann, Christine</creatorcontrib><creatorcontrib>Simpson, David M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verma, Susama</au><au>Cikurel, Katia</au><au>Koralnik, Igor J.</au><au>Morgello, Susan</au><au>Cunningham-Rundles, Charlotte</au><au>Weinstein, Zelig R.</au><au>Bergmann, Christine</au><au>Simpson, David M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2007-09-01</date><risdate>2007</risdate><volume>196</volume><issue>5</issue><spage>709</spage><epage>711</epage><pages>709-711</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Progressive multifocal leukoencephalopathy (PML) is a usually fatal cerebral white matter disease found in patients with human immunodeficiency virus infection and other immunocompromised states. We present the case of a 63-year-old woman with polycythemia vera who developed a progressive focal neurological deficit with white matter abnormalities on magnetic resonance images of the brain that was proved on biopsy to be PML. She was treated with the serotonin reuptake inhibitor mirtazapine and remains neurologically stable, with resolution of cerebral lesions, >2 years after diagnosis. We propose that mirtazapine should be investigated further for use in PML.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>17674313</pmid><doi>10.1086/520514</doi><tpages>3</tpages></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases JC virus Lesions Leukoencephalopathies Leukoencephalopathy, Progressive Multifocal - complications Leukoencephalopathy, Progressive Multifocal - drug therapy Leukoencephalopathy, Progressive Multifocal - pathology Medical sciences Mianserin - analogs & derivatives Mianserin - therapeutic use Microbiology Middle Aged Miscellaneous Neuroglia Polycythemia Vera - complications Polycythemia Vera - pathology Progressive multifocal leukoencephalopathy Receptors Serotonin Uptake Inhibitors - therapeutic use T lymphocytes Viral diseases Viral diseases of the nervous system Virology Viruses White matter |
| title | Mirtazapine in Progressive Multifocal Leukoencephalopathy Associated with Polycythemia Vera |
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