C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients
Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population. Method: We examined the genotypic distribution of this SNP in a set of clinical...
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| Veröffentlicht in: | Acta Psychiatrica Scandinavica 2006-12, Vol.114 (6), p.435-438 |
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| container_title | Acta Psychiatrica Scandinavica |
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| creator | Hoenicka, J. Aragüés, M. Rodríguez-Jiménez, R. Ponce, G. Martínez, I. Rubio, G. Jiménez-Arriero, M. A. Palomo, T. |
| description | Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.
Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age‐matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.
Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over‐represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4).
Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia. |
| doi_str_mv | 10.1111/j.1600-0447.2006.00874.x |
| format | Article |
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Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age‐matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.
Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over‐represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4).
Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>EISSN: 0065-1591</identifier><identifier>DOI: 10.1111/j.1600-0447.2006.00874.x</identifier><identifier>PMID: 17087792</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Alleles ; Biological and medical sciences ; dopamine ; dopamine-D2 receptor ; Female ; Gene Frequency - genetics ; genetic polymorphism ; Genetic Predisposition to Disease - genetics ; Genetic Variation - genetics ; Genotype ; Homozygote ; Humans ; Male ; Medical sciences ; Polymorphism, Single Nucleotide - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Receptors, Dopamine D2 - genetics ; Risk Factors ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - genetics ; Spain</subject><ispartof>Acta Psychiatrica Scandinavica, 2006-12, Vol.114 (6), p.435-438</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4664-f257dc6a7ee691816c89143c414501d71993e3dbbdd6bb646ad069a5673eed6c3</citedby><cites>FETCH-LOGICAL-c4664-f257dc6a7ee691816c89143c414501d71993e3dbbdd6bb646ad069a5673eed6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2006.00874.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2006.00874.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18287692$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17087792$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoenicka, J.</creatorcontrib><creatorcontrib>Aragüés, M.</creatorcontrib><creatorcontrib>Rodríguez-Jiménez, R.</creatorcontrib><creatorcontrib>Ponce, G.</creatorcontrib><creatorcontrib>Martínez, I.</creatorcontrib><creatorcontrib>Rubio, G.</creatorcontrib><creatorcontrib>Jiménez-Arriero, M. A.</creatorcontrib><creatorcontrib>Palomo, T.</creatorcontrib><creatorcontrib>Psychosis and Addictions Research Group (PARG)</creatorcontrib><title>C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients</title><title>Acta Psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.
Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age‐matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.
Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over‐represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4).
Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Alleles</subject><subject>Biological and medical sciences</subject><subject>dopamine</subject><subject>dopamine-D2 receptor</subject><subject>Female</subject><subject>Gene Frequency - genetics</subject><subject>genetic polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic Variation - genetics</subject><subject>Genotype</subject><subject>Homozygote</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Risk Factors</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><subject>Spain</subject><issn>0001-690X</issn><issn>1600-0447</issn><issn>0065-1591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE2PEyEYgInRuHX1LxguepuRd4aB4eBh0-quSeNXa_RGGIZmqPMl7zTb7q-Xbpvdo3IBwvMAeQihwFKI4902BcFYwjiXacaYSBkrJU_3T8js4eApmTHGIBGK_bogLxC3cVsAK5-TC5CRlyqbkeVcFXJNF98XGR2H9tANYWw8dtQjNYiD9WZyNb31U0PRNv5uGJvgem-o7-lqNL3Hho5m8q6f8CV5tjEtulfn-ZL8-PhhPb9Jll-uP82vlonlQvBkkxWytsJI54SCEoQtFfDccuAFg1qCUrnL66qqa1FVggtTM6FMIWTuXC1sfknenu4dw_Bn53DSnUfr2tb0btihFiWAyiD7JwiqEALyIoLlCbRhQAxuo8fgOxMOGpg-JtdbfSyrj2X1Mbm-T673UX19fmNXda5-FM-NI_DmDBi0pt0E01uPj1yZlVLcc-9P3K1v3eG_P6Cv5l9XcRX95OR7nNz-wTfht47lZKF_fr7Wq28554v1Si_yv90hqmg</recordid><startdate>200612</startdate><enddate>200612</enddate><creator>Hoenicka, J.</creator><creator>Aragüés, M.</creator><creator>Rodríguez-Jiménez, R.</creator><creator>Ponce, G.</creator><creator>Martínez, I.</creator><creator>Rubio, G.</creator><creator>Jiménez-Arriero, M. A.</creator><creator>Palomo, T.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>200612</creationdate><title>C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients</title><author>Hoenicka, J. ; Aragüés, M. ; Rodríguez-Jiménez, R. ; Ponce, G. ; Martínez, I. ; Rubio, G. ; Jiménez-Arriero, M. A. ; Palomo, T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4664-f257dc6a7ee691816c89143c414501d71993e3dbbdd6bb646ad069a5673eed6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Alleles</topic><topic>Biological and medical sciences</topic><topic>dopamine</topic><topic>dopamine-D2 receptor</topic><topic>Female</topic><topic>Gene Frequency - genetics</topic><topic>genetic polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic Variation - genetics</topic><topic>Genotype</topic><topic>Homozygote</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>Risk Factors</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><topic>Spain</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoenicka, J.</creatorcontrib><creatorcontrib>Aragüés, M.</creatorcontrib><creatorcontrib>Rodríguez-Jiménez, R.</creatorcontrib><creatorcontrib>Ponce, G.</creatorcontrib><creatorcontrib>Martínez, I.</creatorcontrib><creatorcontrib>Rubio, G.</creatorcontrib><creatorcontrib>Jiménez-Arriero, M. A.</creatorcontrib><creatorcontrib>Palomo, T.</creatorcontrib><creatorcontrib>Psychosis and Addictions Research Group (PARG)</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoenicka, J.</au><au>Aragüés, M.</au><au>Rodríguez-Jiménez, R.</au><au>Ponce, G.</au><au>Martínez, I.</au><au>Rubio, G.</au><au>Jiménez-Arriero, M. A.</au><au>Palomo, T.</au><aucorp>Psychosis and Addictions Research Group (PARG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients</atitle><jtitle>Acta Psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2006-12</date><risdate>2006</risdate><volume>114</volume><issue>6</issue><spage>435</spage><epage>438</epage><pages>435-438</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><eissn>0065-1591</eissn><coden>APYSA9</coden><abstract>Objective: The objective was to confirm whether a homozygous genotype for the C957 allele of the C957T DRD2 gene single nucleotide polymorphism (SNP) is associated with schizophrenia in an independent study population.
Method: We examined the genotypic distribution of this SNP in a set of clinically ascertained schizophrenic patients (n = 131) and age‐matched control subjects (n = 364). Individuals were genotyped using automated analysis of fluorescently labeled PCR products.
Results: The distribution of grouped genotypes for the C957T DRD2 SNP (CC vs. CT, TT) showed that C homozygote genotype was over‐represented in our patient sample when compared with control subjects. This difference reaches the statistical significance (χ2 = 7.0; df = 1; P = 0.008; OR = 2.05; % CI 1.2–3.4).
Conclusion: The findings of this study provide additional evidence that genetic variation at the DRD2 gene plays an important role in the vulnerability to schizophrenia.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17087792</pmid><doi>10.1111/j.1600-0447.2006.00874.x</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Adult and adolescent clinical studies Alleles Biological and medical sciences dopamine dopamine-D2 receptor Female Gene Frequency - genetics genetic polymorphism Genetic Predisposition to Disease - genetics Genetic Variation - genetics Genotype Homozygote Humans Male Medical sciences Polymorphism, Single Nucleotide - genetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Receptors, Dopamine D2 - genetics Risk Factors Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Spain |
| title | C957T DRD2 polymorphism is associated with schizophrenia in Spanish patients |
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