Saw palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling

PC-SPES is an eight-herb mixture that has an activity against prostate cancer. Recently, we purified Saw Palmetto (Serenoa repens) from PC-SPES and found that Saw Palmetto induced growth arrest of prostate cancer LNCaP, DU145, and PC3 cells with ED50s of approximately 2.0, 2.6, and 3.3 microl/ml, re...

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Veröffentlicht in:	International journal of oncology 2007-09, Vol.31 (3), p.593-600
Hauptverfasser:	YANG YANG, IKEZOE, Takayuki, ZHIXING ZHENG, TAGUCHI, Hirokuni, KOEFFLER, H. Phillip, ZHU, Wei-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Antagonists - pharmacology Animals Apoptosis Biological and medical sciences Cell Line, Tumor Cell Proliferation Gene Expression Regulation, Neoplastic Humans Interleukin-6 - metabolism Male Medical sciences Mice Mice, Inbred BALB C Mice, Nude Nephrology. Urinary tract diseases Plant Extracts - pharmacology Prostate-Specific Antigen - biosynthesis Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Signal Transduction STAT3 Transcription Factor - metabolism Tumors Tumors of the urinary system Urinary tract. Prostate gland
Online-Zugang:	Volltext
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