An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer

The title compounds were revealed. These potently exhibited DNA-dependent RNA synthesis. Novel cyclic thiopeptides, cyclothiazomycins B1 ( 1) and B2 ( 2), were isolated from Streptomyces sp. A307 as potent hyphal swelling inducing substances. They are stable in the solid state but slowly isomerize w...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-12, Vol.14 (24), p.8259-8270
Hauptverfasser:	Hashimoto, Masaru, Murakami, Takanori, Funahashi, Katsuyuki, Tokunaga, Takashi, Nihei, Ken-ichi, Okuno, Toshikatsu, Kimura, Takatsugu, Naoki, Hideo, Himeno, Hyouta
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents Applied microbiology Biological and medical sciences Chromatography, High Pressure Liquid Cyclic thiopeptide Cyclothiazomycin B DNA-Directed RNA Polymerases - antagonists & inhibitors Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Fermentation Fundamental and applied biological sciences. Psychology General aspects Isomerism Isomerization of dehydrohomoalanine Magnetic Resonance Spectroscopy Microbiology Molecular Structure Peptides - chemistry Peptides - isolation & purification Peptides - pharmacology Peptides, Cyclic - chemistry Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Renin - antagonists & inhibitors RNA polymerase inhibition Streptomyces Streptomyces - classification Streptomyces - metabolism Structure-Activity Relationship Thiazoles - chemistry Thiazoles - isolation & purification Thiazoles - pharmacology
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