Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors
We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue witho...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2006, Vol.68(10), pp.1069-1074 |
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| container_title | Journal of Veterinary Medical Science |
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| creator | Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.) Medan, M.S Azuma, T Kawabata, K Shimoda, M Umemura, S |
| description | We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue without injuring the surrounding organs. We therefore established a localized tumor model by inoculating VX2 tumor into rabbit livers. The localized VX2 tumors of nine rabbits were transdermally treated with split-focus ablation at a peak intensity in water of 6 kW/cm2 for 4 s (6 shots) under the guidance of ultrasonic B-mode imaging. Necropsy a day after treatment found the surface of the livers and gastrointestinal tracts to be grossly normal. The VX2 tumors were completely coagulated and were surrounded by ablated liver tissue. The six shots of split-focus HIFU destroyed the VX2 tumors without injuring the liver surfaces or the surrounding organs. These results suggest that split-focus HIFU ablation could be an effective treatment of localized tumors. |
| doi_str_mv | 10.1292/jvms.68.1069 |
| format | Article |
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Central Research Lab.) ; Medan, M.S ; Azuma, T ; Kawabata, K ; Shimoda, M ; Umemura, S</creator><creatorcontrib>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.) ; Medan, M.S ; Azuma, T ; Kawabata, K ; Shimoda, M ; Umemura, S</creatorcontrib><description>We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue without injuring the surrounding organs. We therefore established a localized tumor model by inoculating VX2 tumor into rabbit livers. The localized VX2 tumors of nine rabbits were transdermally treated with split-focus ablation at a peak intensity in water of 6 kW/cm2 for 4 s (6 shots) under the guidance of ultrasonic B-mode imaging. Necropsy a day after treatment found the surface of the livers and gastrointestinal tracts to be grossly normal. The VX2 tumors were completely coagulated and were surrounded by ablated liver tissue. The six shots of split-focus HIFU destroyed the VX2 tumors without injuring the liver surfaces or the surrounding organs. These results suggest that split-focus HIFU ablation could be an effective treatment of localized tumors.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.68.1069</identifier><identifier>PMID: 17085885</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; CONEJO (ORYCTOLAGUS) ; Female ; FOIE ; HIFU ; HIGADO ; LAPIN (ORYCTOLAGUS) ; LIVER ; Liver Neoplasms, Experimental - diagnostic imaging ; Liver Neoplasms, Experimental - surgery ; MODELE ; MODELOS ; NEOPLASMAS ; NEOPLASME ; NEOPLASMS ; rabbit ; RABBITS ; split-focus ; TERAPIA ; THERAPEUTIQUE ; THERAPY ; ULTRASON ; ULTRASONICS ; ULTRASONIDO ; Ultrasonography, Interventional - methods ; Ultrasonography, Interventional - veterinary ; VX2</subject><ispartof>Journal of Veterinary Medical Science, 2006, Vol.68(10), pp.1069-1074</ispartof><rights>2006 by the Japanese Society of Veterinary Science</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c618t-3341c0f4b2405b25fe58a8898040eb6dcea0f29819e766e0d1359f3ad1382bf23</citedby><cites>FETCH-LOGICAL-c618t-3341c0f4b2405b25fe58a8898040eb6dcea0f29819e766e0d1359f3ad1382bf23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17085885$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.)</creatorcontrib><creatorcontrib>Medan, M.S</creatorcontrib><creatorcontrib>Azuma, T</creatorcontrib><creatorcontrib>Kawabata, K</creatorcontrib><creatorcontrib>Shimoda, M</creatorcontrib><creatorcontrib>Umemura, S</creatorcontrib><title>Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue without injuring the surrounding organs. We therefore established a localized tumor model by inoculating VX2 tumor into rabbit livers. The localized VX2 tumors of nine rabbits were transdermally treated with split-focus ablation at a peak intensity in water of 6 kW/cm2 for 4 s (6 shots) under the guidance of ultrasonic B-mode imaging. Necropsy a day after treatment found the surface of the livers and gastrointestinal tracts to be grossly normal. The VX2 tumors were completely coagulated and were surrounded by ablated liver tissue. The six shots of split-focus HIFU destroyed the VX2 tumors without injuring the liver surfaces or the surrounding organs. These results suggest that split-focus HIFU ablation could be an effective treatment of localized tumors.</description><subject>Animals</subject><subject>CONEJO (ORYCTOLAGUS)</subject><subject>Female</subject><subject>FOIE</subject><subject>HIFU</subject><subject>HIGADO</subject><subject>LAPIN (ORYCTOLAGUS)</subject><subject>LIVER</subject><subject>Liver Neoplasms, Experimental - diagnostic imaging</subject><subject>Liver Neoplasms, Experimental - surgery</subject><subject>MODELE</subject><subject>MODELOS</subject><subject>NEOPLASMAS</subject><subject>NEOPLASME</subject><subject>NEOPLASMS</subject><subject>rabbit</subject><subject>RABBITS</subject><subject>split-focus</subject><subject>TERAPIA</subject><subject>THERAPEUTIQUE</subject><subject>THERAPY</subject><subject>ULTRASON</subject><subject>ULTRASONICS</subject><subject>ULTRASONIDO</subject><subject>Ultrasonography, Interventional - methods</subject><subject>Ultrasonography, Interventional - veterinary</subject><subject>VX2</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9rFDEUx4NY7Fq9eVUGhJ6cNclk8uNYllZbCnrQc8hkXnazzEzWJCPWv94Mu1TpRQh58N6HT8j7IvSG4DWhin7c_xzTmss1wVw9QyvSMFEL1qjnaIUV4bWgLT5HL1PaY0wJ4-oFOicCy1bKdoXMtXNgcxVcBXYX6u3se-irnd_uaj9lmJLPD5ULdk6lPQ85mhTmqa9MN5jsw1SVMwRrBv-7APDrANGPMGUzVHkeQ0yv0JkzQ4LXp3qBvt9cf9t8ru-_fLrdXN3XlhOZ66ZhxGLHOspw29HWQSuNlEpihqHjvQWDHVWSKBCcA-5J0yrXmFIl7RxtLtDl0XuI4ccMKevRJwvDYCYIc9JcEiKEYv8FiWKCM7oY3z8B92GOU_mELnuUguBGqUJ9OFI2hpQiOH0oGzDxQROsl4T0klB5Xi8JFfzdSTp3I_R_4VMkBdgcgX3KZguPgInZ2wH-sZ3uRfs4tTsTNUzF8vZocSZos40-6buvFGOBMZOkbf4AfM6tyw</recordid><startdate>20061001</startdate><enddate>20061001</enddate><creator>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.)</creator><creator>Medan, M.S</creator><creator>Azuma, T</creator><creator>Kawabata, K</creator><creator>Shimoda, M</creator><creator>Umemura, S</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>Japan Science and Technology Agency</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>20061001</creationdate><title>Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors</title><author>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.) ; Medan, M.S ; Azuma, T ; Kawabata, K ; Shimoda, M ; Umemura, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c618t-3341c0f4b2405b25fe58a8898040eb6dcea0f29819e766e0d1359f3ad1382bf23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>CONEJO (ORYCTOLAGUS)</topic><topic>Female</topic><topic>FOIE</topic><topic>HIFU</topic><topic>HIGADO</topic><topic>LAPIN (ORYCTOLAGUS)</topic><topic>LIVER</topic><topic>Liver Neoplasms, Experimental - diagnostic imaging</topic><topic>Liver Neoplasms, Experimental - surgery</topic><topic>MODELE</topic><topic>MODELOS</topic><topic>NEOPLASMAS</topic><topic>NEOPLASME</topic><topic>NEOPLASMS</topic><topic>rabbit</topic><topic>RABBITS</topic><topic>split-focus</topic><topic>TERAPIA</topic><topic>THERAPEUTIQUE</topic><topic>THERAPY</topic><topic>ULTRASON</topic><topic>ULTRASONICS</topic><topic>ULTRASONIDO</topic><topic>Ultrasonography, Interventional - methods</topic><topic>Ultrasonography, Interventional - veterinary</topic><topic>VX2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.)</creatorcontrib><creatorcontrib>Medan, M.S</creatorcontrib><creatorcontrib>Azuma, T</creatorcontrib><creatorcontrib>Kawabata, K</creatorcontrib><creatorcontrib>Shimoda, M</creatorcontrib><creatorcontrib>Umemura, S</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sasaki, K.(Hitachi Ltd., Kokubunji, Tokyo (Japan). Central Research Lab.)</au><au>Medan, M.S</au><au>Azuma, T</au><au>Kawabata, K</au><au>Shimoda, M</au><au>Umemura, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2006-10-01</date><risdate>2006</risdate><volume>68</volume><issue>10</issue><spage>1069</spage><epage>1074</epage><pages>1069-1074</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>We fabricated a prototype 3.25-MHz split-focus therapeutic transducer combined with a small 6.5-MHz imaging ultrasonic probe for transrectal treatment of prostate cancer and evaluated the feasibility of using split-focus high-intensity focused ultrasound (HIFU) to ablate localized tumor tissue without injuring the surrounding organs. We therefore established a localized tumor model by inoculating VX2 tumor into rabbit livers. The localized VX2 tumors of nine rabbits were transdermally treated with split-focus ablation at a peak intensity in water of 6 kW/cm2 for 4 s (6 shots) under the guidance of ultrasonic B-mode imaging. Necropsy a day after treatment found the surface of the livers and gastrointestinal tracts to be grossly normal. The VX2 tumors were completely coagulated and were surrounded by ablated liver tissue. The six shots of split-focus HIFU destroyed the VX2 tumors without injuring the liver surfaces or the surrounding organs. These results suggest that split-focus HIFU ablation could be an effective treatment of localized tumors.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>17085885</pmid><doi>10.1292/jvms.68.1069</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals CONEJO (ORYCTOLAGUS) Female FOIE HIFU HIGADO LAPIN (ORYCTOLAGUS) LIVER Liver Neoplasms, Experimental - diagnostic imaging Liver Neoplasms, Experimental - surgery MODELE MODELOS NEOPLASMAS NEOPLASME NEOPLASMS rabbit RABBITS split-focus TERAPIA THERAPEUTIQUE THERAPY ULTRASON ULTRASONICS ULTRASONIDO Ultrasonography, Interventional - methods Ultrasonography, Interventional - veterinary VX2 |
| title | Effect of echo-guided high-intensity focused ultrasound ablation on localized experimental tumors |
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