Large and small vessel vasoconstriction following coronary artery stenting Effect of intra coronary nitroglycerine and relation to LDL cholesterol
Percutaneous coronary intervention (PCI) with stent placement induces epicardial coronary vasoconstriction, which is resolved by intracoronary (IC) nitroglycerine (NTG). The effect of stenting on microvascular coronary circulation and coronary blood flow (CBF) is less well established, and the effec...
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| Veröffentlicht in: | International journal of cardiology 2006-10, Vol.113 (1), p.61-65 |
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| description | Percutaneous coronary intervention (PCI) with stent placement induces epicardial coronary vasoconstriction, which is resolved by intracoronary (IC) nitroglycerine (NTG). The effect of stenting on microvascular coronary circulation and coronary blood flow (CBF) is less well established, and the effect of NTG on CBF following stenting is unknown. We examined the time course, extent, and influence of NTG, on PCI induced coronary vasoconstriction. Secondarily we also did an explorative analysis to evaluate the effect of increased levels of low density lipoprotein cholesterol (LDL-Cholesterol) on CBF after stenting.
Single vessel PCI stent was performed in 19 patients (age 62+/-10 years). Immediately after PCI, a 0.014 Doppler flow-wire was positioned distal to the stent, and IC NTG 0.2 mg was given. Quantitative coronary angiography (QCA) and CBF measurements were taken at baseline, and at 10, 20 and 30 min following PCI. Further IC NTG 200 mug was given after the measurement at 30 min, and the measurements were repeated at 31 and 33 min. Coronary flow velocity reserve (CFVR) was measured with adenosine IC bolus.
Compared to baseline, there were significant reductions in CBF (24.5+/-18.3%), (35+/-30 vs. 28+/-25 ml/min, p=0.001) and coronary arterial diameter (5.1+/-5.4%) (2.63+/-0.54 vs. 2.50 mm+/-0.53, p=0.008) within 30 min following PCI. Subsequent IC NTG reversed both small (28+/-25 vs. 44+/-30 ml/min, p |
| doi_str_mv | 10.1016/j.ijcard.2005.10.027 |
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Single vessel PCI stent was performed in 19 patients (age 62+/-10 years). Immediately after PCI, a 0.014 Doppler flow-wire was positioned distal to the stent, and IC NTG 0.2 mg was given. Quantitative coronary angiography (QCA) and CBF measurements were taken at baseline, and at 10, 20 and 30 min following PCI. Further IC NTG 200 mug was given after the measurement at 30 min, and the measurements were repeated at 31 and 33 min. Coronary flow velocity reserve (CFVR) was measured with adenosine IC bolus.
Compared to baseline, there were significant reductions in CBF (24.5+/-18.3%), (35+/-30 vs. 28+/-25 ml/min, p=0.001) and coronary arterial diameter (5.1+/-5.4%) (2.63+/-0.54 vs. 2.50 mm+/-0.53, p=0.008) within 30 min following PCI. Subsequent IC NTG reversed both small (28+/-25 vs. 44+/-30 ml/min, p<0.001) and large (2.50+/-0.53 vs. 2.80+/-0.59 mm, p=0.001) vessel PCI induced vasoconstriction. LDL-cholesterol was significantly correlated to the percent reduction of blood-flow within 30 min (r=0.515, p=0.024, n=19) and to the maximal CBF after NTG (r=0.520, p=0.022, n=19).
Following PCI, both large and small vessel vasoconstriction are seen as manifest by a reduction in coronary conduit vessel diameter and in CBF. These effects are reversed by NTG. Serum levels of LDL are modestly related to the reduction of CBF and to the degree of NTG induced vasodilatation of coronary micro-vasculature.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2005.10.027</identifier><identifier>PMID: 16337702</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Science</publisher><subject>Aged ; Angioplasty, Balloon, Coronary - adverse effects ; Biological and medical sciences ; Cardiology. Vascular system ; Cholesterol, LDL - blood ; Coronary Artery Disease - blood ; Coronary Artery Disease - therapy ; Coronary Circulation - drug effects ; Coronary heart disease ; Coronary Vessels ; Diseases of the cardiovascular system ; Heart ; Humans ; Medical sciences ; Middle Aged ; Nitroglycerin - administration & dosage ; Nitroglycerin - therapeutic use ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Stents - adverse effects ; Time Factors ; Vasoconstriction - drug effects ; Vasodilator Agents - administration & dosage ; Vasodilator Agents - therapeutic use</subject><ispartof>International journal of cardiology, 2006-10, Vol.113 (1), p.61-65</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18275174$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16337702$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LARSEN, Alf Inge</creatorcontrib><creatorcontrib>BASRAN, Rashpal</creatorcontrib><creatorcontrib>ANDERSON, Todd</creatorcontrib><creatorcontrib>GOODHART, David</creatorcontrib><creatorcontrib>FICS study group</creatorcontrib><title>Large and small vessel vasoconstriction following coronary artery stenting Effect of intra coronary nitroglycerine and relation to LDL cholesterol</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Percutaneous coronary intervention (PCI) with stent placement induces epicardial coronary vasoconstriction, which is resolved by intracoronary (IC) nitroglycerine (NTG). The effect of stenting on microvascular coronary circulation and coronary blood flow (CBF) is less well established, and the effect of NTG on CBF following stenting is unknown. We examined the time course, extent, and influence of NTG, on PCI induced coronary vasoconstriction. Secondarily we also did an explorative analysis to evaluate the effect of increased levels of low density lipoprotein cholesterol (LDL-Cholesterol) on CBF after stenting.
Single vessel PCI stent was performed in 19 patients (age 62+/-10 years). Immediately after PCI, a 0.014 Doppler flow-wire was positioned distal to the stent, and IC NTG 0.2 mg was given. Quantitative coronary angiography (QCA) and CBF measurements were taken at baseline, and at 10, 20 and 30 min following PCI. Further IC NTG 200 mug was given after the measurement at 30 min, and the measurements were repeated at 31 and 33 min. Coronary flow velocity reserve (CFVR) was measured with adenosine IC bolus.
Compared to baseline, there were significant reductions in CBF (24.5+/-18.3%), (35+/-30 vs. 28+/-25 ml/min, p=0.001) and coronary arterial diameter (5.1+/-5.4%) (2.63+/-0.54 vs. 2.50 mm+/-0.53, p=0.008) within 30 min following PCI. Subsequent IC NTG reversed both small (28+/-25 vs. 44+/-30 ml/min, p<0.001) and large (2.50+/-0.53 vs. 2.80+/-0.59 mm, p=0.001) vessel PCI induced vasoconstriction. LDL-cholesterol was significantly correlated to the percent reduction of blood-flow within 30 min (r=0.515, p=0.024, n=19) and to the maximal CBF after NTG (r=0.520, p=0.022, n=19).
Following PCI, both large and small vessel vasoconstriction are seen as manifest by a reduction in coronary conduit vessel diameter and in CBF. These effects are reversed by NTG. Serum levels of LDL are modestly related to the reduction of CBF and to the degree of NTG induced vasodilatation of coronary micro-vasculature.</description><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Cardiology. Vascular system</subject><subject>Cholesterol, LDL - blood</subject><subject>Coronary Artery Disease - blood</subject><subject>Coronary Artery Disease - therapy</subject><subject>Coronary Circulation - drug effects</subject><subject>Coronary heart disease</subject><subject>Coronary Vessels</subject><subject>Diseases of the cardiovascular system</subject><subject>Heart</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nitroglycerin - administration & dosage</subject><subject>Nitroglycerin - therapeutic use</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Stents - adverse effects</subject><subject>Time Factors</subject><subject>Vasoconstriction - drug effects</subject><subject>Vasodilator Agents - administration & dosage</subject><subject>Vasodilator Agents - therapeutic use</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1P3DAQhi0EKlvaf1BVvsAtqT8SOzmiBdpKkXqB82riTBavvPZie6n4G_xi3O4iTo808-h9NUPIN85qzrj6santxkCcasFYW0Y1E_qELHinm4rrtjkli6LpqhVanpPPKW0YY03fd5_IOVdSas3EgrwOENdIwU80bcE5-owpYQGkYIJPOVqTbfB0Ds6Fv9avqQkxeIgvFGLGgpTR53-L23lGk2mYqfU5wofobY5h7V4MRusPZREd_M_NgQ43AzWPwWFJisF9IWczuIRfj7wgD3e398tf1fDn5-_l9VDthOxzNUmjG4W61z0XDUNu-DiCVFx0rNcoZwmSawkoGpy0GI0y46imrjW6G2cu5QW5OuTuYnjal_LV1iaDzoHHsE8r1XGuGiWK-P0o7sctTqtdtNty1ur9i0W4PAqQDLg5gjc2fXid0C3XjXwDdV-HBA</recordid><startdate>20061026</startdate><enddate>20061026</enddate><creator>LARSEN, Alf Inge</creator><creator>BASRAN, Rashpal</creator><creator>ANDERSON, Todd</creator><creator>GOODHART, David</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20061026</creationdate><title>Large and small vessel vasoconstriction following coronary artery stenting Effect of intra coronary nitroglycerine and relation to LDL cholesterol</title><author>LARSEN, Alf Inge ; BASRAN, Rashpal ; ANDERSON, Todd ; GOODHART, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-d3c746e79791240e1c1bba36128097e3f3a3173ae24ed72bc6cbb6d85c78bf133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Cardiology. Vascular system</topic><topic>Cholesterol, LDL - blood</topic><topic>Coronary Artery Disease - blood</topic><topic>Coronary Artery Disease - therapy</topic><topic>Coronary Circulation - drug effects</topic><topic>Coronary heart disease</topic><topic>Coronary Vessels</topic><topic>Diseases of the cardiovascular system</topic><topic>Heart</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nitroglycerin - administration & dosage</topic><topic>Nitroglycerin - therapeutic use</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Stents - adverse effects</topic><topic>Time Factors</topic><topic>Vasoconstriction - drug effects</topic><topic>Vasodilator Agents - administration & dosage</topic><topic>Vasodilator Agents - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LARSEN, Alf Inge</creatorcontrib><creatorcontrib>BASRAN, Rashpal</creatorcontrib><creatorcontrib>ANDERSON, Todd</creatorcontrib><creatorcontrib>GOODHART, David</creatorcontrib><creatorcontrib>FICS study group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LARSEN, Alf Inge</au><au>BASRAN, Rashpal</au><au>ANDERSON, Todd</au><au>GOODHART, David</au><aucorp>FICS study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Large and small vessel vasoconstriction following coronary artery stenting Effect of intra coronary nitroglycerine and relation to LDL cholesterol</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2006-10-26</date><risdate>2006</risdate><volume>113</volume><issue>1</issue><spage>61</spage><epage>65</epage><pages>61-65</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Percutaneous coronary intervention (PCI) with stent placement induces epicardial coronary vasoconstriction, which is resolved by intracoronary (IC) nitroglycerine (NTG). The effect of stenting on microvascular coronary circulation and coronary blood flow (CBF) is less well established, and the effect of NTG on CBF following stenting is unknown. We examined the time course, extent, and influence of NTG, on PCI induced coronary vasoconstriction. Secondarily we also did an explorative analysis to evaluate the effect of increased levels of low density lipoprotein cholesterol (LDL-Cholesterol) on CBF after stenting.
Single vessel PCI stent was performed in 19 patients (age 62+/-10 years). Immediately after PCI, a 0.014 Doppler flow-wire was positioned distal to the stent, and IC NTG 0.2 mg was given. Quantitative coronary angiography (QCA) and CBF measurements were taken at baseline, and at 10, 20 and 30 min following PCI. Further IC NTG 200 mug was given after the measurement at 30 min, and the measurements were repeated at 31 and 33 min. Coronary flow velocity reserve (CFVR) was measured with adenosine IC bolus.
Compared to baseline, there were significant reductions in CBF (24.5+/-18.3%), (35+/-30 vs. 28+/-25 ml/min, p=0.001) and coronary arterial diameter (5.1+/-5.4%) (2.63+/-0.54 vs. 2.50 mm+/-0.53, p=0.008) within 30 min following PCI. Subsequent IC NTG reversed both small (28+/-25 vs. 44+/-30 ml/min, p<0.001) and large (2.50+/-0.53 vs. 2.80+/-0.59 mm, p=0.001) vessel PCI induced vasoconstriction. LDL-cholesterol was significantly correlated to the percent reduction of blood-flow within 30 min (r=0.515, p=0.024, n=19) and to the maximal CBF after NTG (r=0.520, p=0.022, n=19).
Following PCI, both large and small vessel vasoconstriction are seen as manifest by a reduction in coronary conduit vessel diameter and in CBF. These effects are reversed by NTG. Serum levels of LDL are modestly related to the reduction of CBF and to the degree of NTG induced vasodilatation of coronary micro-vasculature.</abstract><cop>Shannon</cop><pub>Elsevier Science</pub><pmid>16337702</pmid><doi>10.1016/j.ijcard.2005.10.027</doi><tpages>5</tpages></addata></record> |
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| subjects | Aged Angioplasty, Balloon, Coronary - adverse effects Biological and medical sciences Cardiology. Vascular system Cholesterol, LDL - blood Coronary Artery Disease - blood Coronary Artery Disease - therapy Coronary Circulation - drug effects Coronary heart disease Coronary Vessels Diseases of the cardiovascular system Heart Humans Medical sciences Middle Aged Nitroglycerin - administration & dosage Nitroglycerin - therapeutic use Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Stents - adverse effects Time Factors Vasoconstriction - drug effects Vasodilator Agents - administration & dosage Vasodilator Agents - therapeutic use |
| title | Large and small vessel vasoconstriction following coronary artery stenting Effect of intra coronary nitroglycerine and relation to LDL cholesterol |
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