Quantitative analysis of a proteome by N‐terminal stable‐isotope labelling of tryptic peptides

Covalent modification of peptides and proteins with compounds containing stable isotopes (isotope tagging) has become an essential tool to detect dynamic changes in the proteome following external or internal influence; however, using terminal amino groups for global isotope labelling of tryptic pep...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2007-01, Vol.21 (16), p.2671-2679
Hauptverfasser:	Fedjaev, Michael, Trudel, Stephanie, Tjon‐A‐Pan, Natascha, Parmar, Amanda, Posner, Barry I., Levy, Emile, Nifant'ev, Ilya, Pshezhetsky, Alexey V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - analysis Caco-2 Cells Chromatography, High Pressure Liquid - methods Humans Isotope Labeling - methods Liver - metabolism Neoplasm Proteins - analysis Peptides - chemistry Proteome - analysis Proteome - chemistry Rats Rats, Sprague-Dawley Reproducibility of Results Sensitivity and Specificity Spectrometry, Mass, Electrospray Ionization - methods Trypsin - chemistry
Online-Zugang:	Volltext
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