Saucernetin-7 Isolated from Saururus chinensis Induces Caspase-Dependent Apoptosis in Human Promyelocytic Leukemia HL-60 Cells

In the present study, we investigated the effect of saucernetin-7 (a biologically active compound isolated from the underground parts of Saururus chinensi) on the induction of apoptosis and the putative pathways of its action in HL-60 human promyelocytic leukemia cells. Saucernetin-7-treated HL-60 c...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2007/08/01, Vol.30(8), pp.1516-1522
Hauptverfasser:	Choi, Seung-Ki, Seo, Bo-Rim, Lee, Kyung-Won, Cho, Woong, Jeong, Seoung-Hee, Lee, Kyung-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Annexin A5 - metabolism apoptosis Apoptosis - drug effects bax Blotting, Western caspase-8 Caspases - physiology Cell Division - drug effects cytochrome c Cytochromes c - metabolism Cytosol - drug effects Cytosol - metabolism DNA Fragmentation - drug effects Furans - isolation & purification Furans - pharmacology HL-60 Cells Humans Lignans - isolation & purification Lignans - pharmacology Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membranes - drug effects Phosphatidylserines - metabolism Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics saucernetin-7 Saururaceae - chemistry
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