Synthesis and antimicrobial activity of pyranobenzoquinones related to the pyranonaphthoquinone antibiotics

The synthesis and antimicrobial activity of isochromane-type analogs of the pyranonaphthoquinone antibiotics are reported. Isochromane derivatives with ( 17a, b) and without ( 22a, b) a C-4 hydroxyl moiety and their corresponding quinones ( 19a and 23), were prepared. Both quinones exhibited antimic...

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Veröffentlicht in:	European journal of medicinal chemistry 2006-11, Vol.41 (11), p.1333-1338
Hauptverfasser:	Lagorio, S.H., Bianchi, D.A., Sutich, E.G., Kaufman, T.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial activity Benzoquinones - chemical synthesis Benzoquinones - chemistry Benzoquinones - pharmacology Biological and medical sciences Chromans - chemical synthesis Chromans - chemistry Chromans - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Pyranobenzoquinones Pyranonaphthoquinone analogs Spectrophotometry, Infrared
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