The Crystal Structure of the Cytosolic Exopolyphosphatase from Saccharomyces cerevisiae Reveals the Basis for Substrate Specificity

Inorganic long-chain polyphosphate is a ubiquitous linear polymer in biology, consisting of many phosphate moieties linked by phosphoanhydride bonds. It is synthesized by polyphosphate kinase, and metabolised by a number of enzymes, including exo- and endopolyphosphatases. The Saccharomyces cerevisi...

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Veröffentlicht in:	Journal of molecular biology 2007-08, Vol.371 (4), p.1007-1021
Hauptverfasser:	Ugochukwu, Emilie, Lovering, Andrew L., Mather, Owen C., Young, Thomas W., White, Scott A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Anhydride Hydrolases - chemistry Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - isolation & purification Acid Anhydride Hydrolases - metabolism Amino Acid Sequence Binding Sites Cloning, Molecular Cobalt - chemistry Computational Biology Crystallography, X-Ray Cytosol - enzymology DHH family exopolyphosphatase family 2 PPase Gene Expression long-chain polyphosphate Molecular Sequence Data Phosphates - chemistry phosphoesterases Protein Structure, Quaternary Protein Structure, Secondary Protein Structure, Tertiary Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Saccharomyces cerevisiae Saccharomyces cerevisiae - enzymology Saccharomyces cerevisiae - genetics Sequence Alignment Substrate Specificity
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