Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosi...
Gespeichert in:
| Veröffentlicht in: | Movement disorders 2007-07, Vol.22 (10), p.1481-1484 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1484 |
|---|---|
| container_issue | 10 |
| container_start_page | 1481 |
| container_title | Movement disorders |
| container_volume | 22 |
| creator | Balducci, Chiara Pierguidi, Laura Persichetti, Emanuele Parnetti, Lucilla Sbaragli, Michele Tassi, Carmelo Orlacchio, Aldo Calabresi, Paolo Beccari, Tommaso Rossi, Aroldo |
| description | Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.21399 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68108861</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>21169184</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4229-5668f264ac01d81a1879668d75dcc7211ccc08fba2fa6687f46facb265584c343</originalsourceid><addsrcrecordid>eNqFkUtPGzEUha2qFaSURf8Amg1FLAZ8PePHLFGgUClAW1plaXk8tjDMI_XNiObf1yFpWaGurnTvd86Rjwn5CPQEKGWnXYMnDIqqekMmwAvIFePyLZlQpXhegOK75D3iA6UAHMQO2QXJSyGkmpDvsxUOOHSmze5XTRxagw6z0GfWRVfHARehTzffjqHJfBy6DMf6wdklZk9heZ99NfEx9Dj0R5g1AV2SfyDvvGnR7W_nHvn5-eLH9Cqf3V5-mZ7NclsyVuVcCOWZKI2l0CgwoGSVVo3kjbWSAVhrqfK1Yd6kvfSl8MbWTHCuSluUxR75tPFdxOHX6HCpu4DWta3p3TCiFgpSAQL-C6YsUYFaOx5vQJsejtF5vYihM3Glgep10zo1rZ-bTuzB1nSsO9e8kNtqE3C4BQxa0_poehvwhVMVV1KsQ0833FNo3er1RH19fvc3Ot8oAi7d73-K9BNayEJyPb-51Hffrs-ns6u5nhd_AM0wpIE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21169184</pqid></control><display><type>article</type><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Balducci, Chiara ; Pierguidi, Laura ; Persichetti, Emanuele ; Parnetti, Lucilla ; Sbaragli, Michele ; Tassi, Carmelo ; Orlacchio, Aldo ; Calabresi, Paolo ; Beccari, Tommaso ; Rossi, Aroldo</creator><creatorcontrib>Balducci, Chiara ; Pierguidi, Laura ; Persichetti, Emanuele ; Parnetti, Lucilla ; Sbaragli, Michele ; Tassi, Carmelo ; Orlacchio, Aldo ; Calabresi, Paolo ; Beccari, Tommaso ; Rossi, Aroldo</creatorcontrib><description>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.21399</identifier><identifier>PMID: 17546678</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Aged ; Biological and medical sciences ; Chromatography, Ion Exchange - methods ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Hyaluronoglucosaminidase - cerebrospinal fluid ; Male ; Medical sciences ; Middle Aged ; Nervous system (semeiology, syndromes) ; Neurology ; Parkinson Disease - cerebrospinal fluid ; Parkinson's disease ; Statistics, Nonparametric ; α-mannosidase ; β-glucocerebrosidase ; β-hexosaminidase ; β-mannosidase</subject><ispartof>Movement disorders, 2007-07, Vol.22 (10), p.1481-1484</ispartof><rights>Copyright © 2007 Movement Disorder Society</rights><rights>2007 INIST-CNRS</rights><rights>Copyright 2007 Movement Disorder Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4229-5668f264ac01d81a1879668d75dcc7211ccc08fba2fa6687f46facb265584c343</citedby><cites>FETCH-LOGICAL-c4229-5668f264ac01d81a1879668d75dcc7211ccc08fba2fa6687f46facb265584c343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.21399$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.21399$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18958764$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17546678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balducci, Chiara</creatorcontrib><creatorcontrib>Pierguidi, Laura</creatorcontrib><creatorcontrib>Persichetti, Emanuele</creatorcontrib><creatorcontrib>Parnetti, Lucilla</creatorcontrib><creatorcontrib>Sbaragli, Michele</creatorcontrib><creatorcontrib>Tassi, Carmelo</creatorcontrib><creatorcontrib>Orlacchio, Aldo</creatorcontrib><creatorcontrib>Calabresi, Paolo</creatorcontrib><creatorcontrib>Beccari, Tommaso</creatorcontrib><creatorcontrib>Rossi, Aroldo</creatorcontrib><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Chromatography, Ion Exchange - methods</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Hyaluronoglucosaminidase - cerebrospinal fluid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Parkinson Disease - cerebrospinal fluid</subject><subject>Parkinson's disease</subject><subject>Statistics, Nonparametric</subject><subject>α-mannosidase</subject><subject>β-glucocerebrosidase</subject><subject>β-hexosaminidase</subject><subject>β-mannosidase</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPGzEUha2qFaSURf8Amg1FLAZ8PePHLFGgUClAW1plaXk8tjDMI_XNiObf1yFpWaGurnTvd86Rjwn5CPQEKGWnXYMnDIqqekMmwAvIFePyLZlQpXhegOK75D3iA6UAHMQO2QXJSyGkmpDvsxUOOHSmze5XTRxagw6z0GfWRVfHARehTzffjqHJfBy6DMf6wdklZk9heZ99NfEx9Dj0R5g1AV2SfyDvvGnR7W_nHvn5-eLH9Cqf3V5-mZ7NclsyVuVcCOWZKI2l0CgwoGSVVo3kjbWSAVhrqfK1Yd6kvfSl8MbWTHCuSluUxR75tPFdxOHX6HCpu4DWta3p3TCiFgpSAQL-C6YsUYFaOx5vQJsejtF5vYihM3Glgep10zo1rZ-bTuzB1nSsO9e8kNtqE3C4BQxa0_poehvwhVMVV1KsQ0833FNo3er1RH19fvc3Ot8oAi7d73-K9BNayEJyPb-51Hffrs-ns6u5nhd_AM0wpIE</recordid><startdate>20070730</startdate><enddate>20070730</enddate><creator>Balducci, Chiara</creator><creator>Pierguidi, Laura</creator><creator>Persichetti, Emanuele</creator><creator>Parnetti, Lucilla</creator><creator>Sbaragli, Michele</creator><creator>Tassi, Carmelo</creator><creator>Orlacchio, Aldo</creator><creator>Calabresi, Paolo</creator><creator>Beccari, Tommaso</creator><creator>Rossi, Aroldo</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20070730</creationdate><title>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</title><author>Balducci, Chiara ; Pierguidi, Laura ; Persichetti, Emanuele ; Parnetti, Lucilla ; Sbaragli, Michele ; Tassi, Carmelo ; Orlacchio, Aldo ; Calabresi, Paolo ; Beccari, Tommaso ; Rossi, Aroldo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4229-5668f264ac01d81a1879668d75dcc7211ccc08fba2fa6687f46facb265584c343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Chromatography, Ion Exchange - methods</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Hyaluronoglucosaminidase - cerebrospinal fluid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Parkinson Disease - cerebrospinal fluid</topic><topic>Parkinson's disease</topic><topic>Statistics, Nonparametric</topic><topic>α-mannosidase</topic><topic>β-glucocerebrosidase</topic><topic>β-hexosaminidase</topic><topic>β-mannosidase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balducci, Chiara</creatorcontrib><creatorcontrib>Pierguidi, Laura</creatorcontrib><creatorcontrib>Persichetti, Emanuele</creatorcontrib><creatorcontrib>Parnetti, Lucilla</creatorcontrib><creatorcontrib>Sbaragli, Michele</creatorcontrib><creatorcontrib>Tassi, Carmelo</creatorcontrib><creatorcontrib>Orlacchio, Aldo</creatorcontrib><creatorcontrib>Calabresi, Paolo</creatorcontrib><creatorcontrib>Beccari, Tommaso</creatorcontrib><creatorcontrib>Rossi, Aroldo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balducci, Chiara</au><au>Pierguidi, Laura</au><au>Persichetti, Emanuele</au><au>Parnetti, Lucilla</au><au>Sbaragli, Michele</au><au>Tassi, Carmelo</au><au>Orlacchio, Aldo</au><au>Calabresi, Paolo</au><au>Beccari, Tommaso</au><au>Rossi, Aroldo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov. Disord</addtitle><date>2007-07-30</date><risdate>2007</risdate><volume>22</volume><issue>10</issue><spage>1481</spage><epage>1484</epage><pages>1481-1484</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Recent studies have shown a genetic association between glucocerebrosidase deficiencies and Parkinson's disease (PD). To further explore this issue the activity of β‐glucocerebrosidase and the activities of other lysosomal enzymes, α‐mannosidase, β‐mannosidase, β‐hexosaminidase, and β‐galactosidase have been evaluated in the cerebrospinal fluid (CSF) of PD patients. The activities of α‐mannosidase, β‐mannosidase, β‐glucocerebrosidase, and β‐hexosaminidase were substantially decreased in the CSF of PD patients, while levels of β‐galactosidase were essentially identical to controls. This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases. © 2007 Movement Disorder Society</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>17546678</pmid><doi>10.1002/mds.21399</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0885-3185 |
| ispartof | Movement disorders, 2007-07, Vol.22 (10), p.1481-1484 |
| issn | 0885-3185 1531-8257 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68108861 |
| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Aged Biological and medical sciences Chromatography, Ion Exchange - methods Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Hyaluronoglucosaminidase - cerebrospinal fluid Male Medical sciences Middle Aged Nervous system (semeiology, syndromes) Neurology Parkinson Disease - cerebrospinal fluid Parkinson's disease Statistics, Nonparametric α-mannosidase β-glucocerebrosidase β-hexosaminidase β-mannosidase |
| title | Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T15%3A07%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Lysosomal%20hydrolases%20in%20cerebrospinal%20fluid%20from%20subjects%20with%20Parkinson's%20disease&rft.jtitle=Movement%20disorders&rft.au=Balducci,%20Chiara&rft.date=2007-07-30&rft.volume=22&rft.issue=10&rft.spage=1481&rft.epage=1484&rft.pages=1481-1484&rft.issn=0885-3185&rft.eissn=1531-8257&rft_id=info:doi/10.1002/mds.21399&rft_dat=%3Cproquest_cross%3E21169184%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21169184&rft_id=info:pmid/17546678&rfr_iscdi=true |