Lymphocytapheresis in the treatment of psoriasis vulgaris
Psoriasis is a common autoimmune chronic inflammatory skin disease that affects approximately 2% of the world's population; fundamental for its immunopathogenic mechanism is secretion of type 1 (Th1) cytokines by T cells and their activation. Since cytapheresis has been widely applied to autoim...
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| Veröffentlicht in: | Journal of clinical apheresis 2006-10, Vol.21 (3), p.158-164 |
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| creator | Liumbruno, Giancarlo Maria Centoni, Paolo Emilio Molfettini, Pietra Ceretelli, Silvia Ceccarini, Massimo Bachini, Laura Pomponi, Adriano Bagnoni, Giovanni Vitolo, Margherita Eberle, Olimpia Biondi, Alessandro Sodini, Maria Laura |
| description | Psoriasis is a common autoimmune chronic inflammatory skin disease that affects approximately 2% of the world's population; fundamental for its immunopathogenic mechanism is secretion of type 1 (Th1) cytokines by T cells and their activation. Since cytapheresis has been widely applied to autoimmune disorders, emphasizing the recently reported results of granulocyte and monocyte adsorption apheresis in psoriasis, a small series of psoriasis vulgaris (PV) patients underwent lymphocytapheresis (LCA) with the aim to remove lymphocytes. Five patients were submitted to weekly LCA. The severity of the disease had been evaluated through psoriasis area and severity index (PASI) score before LCA and one week after the last apheresis. PASI score before: patient A: 66; patient B: 33; patient C: 50; patient D: 56; patient E: 29. All the patients showed improvement of skin lesions. PASI score after LCA: patient A: 24; patient B: 8; patient C: 5; patient D: 36; patient E: 2.1. No side effects linked to apheresis were reported. LCA seems to produce interesting results in PV, and PASI improvement related to apheresis is clinically significant. Further studies to address its mechanism of action and potential long‐term side effects are needed. It could become a valuable therapeutic alternative or a complementary tool, which might even be used to reduce the dosages of conventional pharmacological therapies adopted for this chronic disease. J. Clin. Apheresis 2006. © 2006 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/jca.20079 |
| format | Article |
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Since cytapheresis has been widely applied to autoimmune disorders, emphasizing the recently reported results of granulocyte and monocyte adsorption apheresis in psoriasis, a small series of psoriasis vulgaris (PV) patients underwent lymphocytapheresis (LCA) with the aim to remove lymphocytes. Five patients were submitted to weekly LCA. The severity of the disease had been evaluated through psoriasis area and severity index (PASI) score before LCA and one week after the last apheresis. PASI score before: patient A: 66; patient B: 33; patient C: 50; patient D: 56; patient E: 29. All the patients showed improvement of skin lesions. PASI score after LCA: patient A: 24; patient B: 8; patient C: 5; patient D: 36; patient E: 2.1. No side effects linked to apheresis were reported. LCA seems to produce interesting results in PV, and PASI improvement related to apheresis is clinically significant. Further studies to address its mechanism of action and potential long‐term side effects are needed. It could become a valuable therapeutic alternative or a complementary tool, which might even be used to reduce the dosages of conventional pharmacological therapies adopted for this chronic disease. J. Clin. Apheresis 2006. © 2006 Wiley‐Liss, Inc.</description><identifier>ISSN: 0733-2459</identifier><identifier>EISSN: 1098-1101</identifier><identifier>DOI: 10.1002/jca.20079</identifier><identifier>PMID: 16425186</identifier><identifier>CODEN: JCAPES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adsorption ; Adult ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral agents ; apheresis ; Autoimmune Diseases - metabolism ; autoimmune skin disease ; Biological and medical sciences ; Blood Component Removal ; Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis ; cytapheresis ; Diseases of the cardiovascular system ; Female ; Granulocytes - cytology ; Humans ; Inflammation ; Leukapheresis - methods ; lymphocyte depletion ; Lymphocytes - cytology ; Male ; Medical sciences ; Middle Aged ; Monocytes - cytology ; PASI ; Pharmacology. Drug treatments ; Psoriasis - pathology ; Psoriasis - therapy ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; Skin - metabolism ; Transfusions. Complications. Transfusion reactions. Cell and gene therapy</subject><ispartof>Journal of clinical apheresis, 2006-10, Vol.21 (3), p.158-164</ispartof><rights>Copyright © 2006 Wiley‐Liss, Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4269-abb71db79f467a2d0dac91177e138f46271e559f344187cbf9059bce727c5ac33</citedby><cites>FETCH-LOGICAL-c4269-abb71db79f467a2d0dac91177e138f46271e559f344187cbf9059bce727c5ac33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjca.20079$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjca.20079$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18256391$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16425186$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liumbruno, Giancarlo Maria</creatorcontrib><creatorcontrib>Centoni, Paolo Emilio</creatorcontrib><creatorcontrib>Molfettini, Pietra</creatorcontrib><creatorcontrib>Ceretelli, Silvia</creatorcontrib><creatorcontrib>Ceccarini, Massimo</creatorcontrib><creatorcontrib>Bachini, Laura</creatorcontrib><creatorcontrib>Pomponi, Adriano</creatorcontrib><creatorcontrib>Bagnoni, Giovanni</creatorcontrib><creatorcontrib>Vitolo, Margherita</creatorcontrib><creatorcontrib>Eberle, Olimpia</creatorcontrib><creatorcontrib>Biondi, Alessandro</creatorcontrib><creatorcontrib>Sodini, Maria Laura</creatorcontrib><title>Lymphocytapheresis in the treatment of psoriasis vulgaris</title><title>Journal of clinical apheresis</title><addtitle>J. Clin. Apheresis</addtitle><description>Psoriasis is a common autoimmune chronic inflammatory skin disease that affects approximately 2% of the world's population; fundamental for its immunopathogenic mechanism is secretion of type 1 (Th1) cytokines by T cells and their activation. Since cytapheresis has been widely applied to autoimmune disorders, emphasizing the recently reported results of granulocyte and monocyte adsorption apheresis in psoriasis, a small series of psoriasis vulgaris (PV) patients underwent lymphocytapheresis (LCA) with the aim to remove lymphocytes. Five patients were submitted to weekly LCA. The severity of the disease had been evaluated through psoriasis area and severity index (PASI) score before LCA and one week after the last apheresis. PASI score before: patient A: 66; patient B: 33; patient C: 50; patient D: 56; patient E: 29. All the patients showed improvement of skin lesions. PASI score after LCA: patient A: 24; patient B: 8; patient C: 5; patient D: 36; patient E: 2.1. No side effects linked to apheresis were reported. LCA seems to produce interesting results in PV, and PASI improvement related to apheresis is clinically significant. Further studies to address its mechanism of action and potential long‐term side effects are needed. It could become a valuable therapeutic alternative or a complementary tool, which might even be used to reduce the dosages of conventional pharmacological therapies adopted for this chronic disease. J. Clin. Apheresis 2006. © 2006 Wiley‐Liss, Inc.</description><subject>Adsorption</subject><subject>Adult</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral agents</subject><subject>apheresis</subject><subject>Autoimmune Diseases - metabolism</subject><subject>autoimmune skin disease</subject><subject>Biological and medical sciences</subject><subject>Blood Component Removal</subject><subject>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</subject><subject>cytapheresis</subject><subject>Diseases of the cardiovascular system</subject><subject>Female</subject><subject>Granulocytes - cytology</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukapheresis - methods</subject><subject>lymphocyte depletion</subject><subject>Lymphocytes - cytology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monocytes - cytology</subject><subject>PASI</subject><subject>Pharmacology. Drug treatments</subject><subject>Psoriasis - pathology</subject><subject>Psoriasis - therapy</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>Skin - metabolism</subject><subject>Transfusions. Complications. Transfusion reactions. 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Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral agents</topic><topic>apheresis</topic><topic>Autoimmune Diseases - metabolism</topic><topic>autoimmune skin disease</topic><topic>Biological and medical sciences</topic><topic>Blood Component Removal</topic><topic>Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis</topic><topic>cytapheresis</topic><topic>Diseases of the cardiovascular system</topic><topic>Female</topic><topic>Granulocytes - cytology</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukapheresis - methods</topic><topic>lymphocyte depletion</topic><topic>Lymphocytes - cytology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monocytes - cytology</topic><topic>PASI</topic><topic>Pharmacology. Drug treatments</topic><topic>Psoriasis - pathology</topic><topic>Psoriasis - therapy</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>Skin - metabolism</topic><topic>Transfusions. Complications. Transfusion reactions. 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Clin. Apheresis</addtitle><date>2006-10</date><risdate>2006</risdate><volume>21</volume><issue>3</issue><spage>158</spage><epage>164</epage><pages>158-164</pages><issn>0733-2459</issn><eissn>1098-1101</eissn><coden>JCAPES</coden><abstract>Psoriasis is a common autoimmune chronic inflammatory skin disease that affects approximately 2% of the world's population; fundamental for its immunopathogenic mechanism is secretion of type 1 (Th1) cytokines by T cells and their activation. Since cytapheresis has been widely applied to autoimmune disorders, emphasizing the recently reported results of granulocyte and monocyte adsorption apheresis in psoriasis, a small series of psoriasis vulgaris (PV) patients underwent lymphocytapheresis (LCA) with the aim to remove lymphocytes. Five patients were submitted to weekly LCA. The severity of the disease had been evaluated through psoriasis area and severity index (PASI) score before LCA and one week after the last apheresis. PASI score before: patient A: 66; patient B: 33; patient C: 50; patient D: 56; patient E: 29. All the patients showed improvement of skin lesions. PASI score after LCA: patient A: 24; patient B: 8; patient C: 5; patient D: 36; patient E: 2.1. No side effects linked to apheresis were reported. LCA seems to produce interesting results in PV, and PASI improvement related to apheresis is clinically significant. Further studies to address its mechanism of action and potential long‐term side effects are needed. It could become a valuable therapeutic alternative or a complementary tool, which might even be used to reduce the dosages of conventional pharmacological therapies adopted for this chronic disease. J. Clin. Apheresis 2006. © 2006 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>16425186</pmid><doi>10.1002/jca.20079</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adsorption Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents apheresis Autoimmune Diseases - metabolism autoimmune skin disease Biological and medical sciences Blood Component Removal Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis cytapheresis Diseases of the cardiovascular system Female Granulocytes - cytology Humans Inflammation Leukapheresis - methods lymphocyte depletion Lymphocytes - cytology Male Medical sciences Middle Aged Monocytes - cytology PASI Pharmacology. Drug treatments Psoriasis - pathology Psoriasis - therapy Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Skin - metabolism Transfusions. Complications. Transfusion reactions. Cell and gene therapy |
| title | Lymphocytapheresis in the treatment of psoriasis vulgaris |
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