Tuberculosis-associated haemophagocytic syndrome
Haemophagocytic syndrome is a disorder characterised by fevers, lymphadenopathy, hepatosplenomegaly, cytopenias, and hyperferritinaemia due to dysregulated activation and proliferation of macrophages, leading to uncontrolled phagocytosis of platelets, erythrocytes, lymphocytes, and their haematopoie...
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| Veröffentlicht in: | The Lancet infectious diseases 2006-07, Vol.6 (7), p.447-454 |
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| creator | Brastianos, Priscilla K Swanson, Jordan W Torbenson, Michael Sperati, John Karakousis, Petros C |
| description | Haemophagocytic syndrome is a disorder characterised by fevers, lymphadenopathy, hepatosplenomegaly, cytopenias, and hyperferritinaemia due to dysregulated activation and proliferation of macrophages, leading to uncontrolled phagocytosis of platelets, erythrocytes, lymphocytes, and their haematopoietic precursors throughout the reticuloendothelial system. Primary or familial haemophagocytic syndrome appears to have a genetic aetiology, whereas secondary haemophagocytic syndrome may be associated with malignancy, autoimmune disease, or infection. Epstein-Barr virus is the most common infectious aetiology implicated in haemophagocytic syndrome, but the syndrome has been associated with a variety of other viral, bacterial, and parasitic pathogens. We describe a case of haemophagocytic syndrome associated with disseminated
Mycobacterium tuberculosis. We review all cases of
M tuberculosis-associated haemophagocytic syndrome reported in the English language literature and discuss important issues pertaining to the epidemiology, diagnosis, and management of this disease. |
| doi_str_mv | 10.1016/S1473-3099(06)70524-2 |
| format | Article |
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Mycobacterium tuberculosis. We review all cases of
M tuberculosis-associated haemophagocytic syndrome reported in the English language literature and discuss important issues pertaining to the epidemiology, diagnosis, and management of this disease.</description><identifier>ISSN: 1473-3099</identifier><identifier>EISSN: 1474-4457</identifier><identifier>DOI: 10.1016/S1473-3099(06)70524-2</identifier><identifier>PMID: 16790385</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Abdominal Pain - etiology ; Adult ; Bacterial diseases ; Biological and medical sciences ; Blood Cell Count ; Diagnosis, Differential ; Epidemiology ; Etiology ; Human bacterial diseases ; Humans ; Infectious diseases ; Lymphocytes ; Lymphohistiocytosis, Hemophagocytic - blood ; Lymphohistiocytosis, Hemophagocytic - complications ; Lymphohistiocytosis, Hemophagocytic - diagnosis ; Male ; Medical sciences ; Mycobacterium tuberculosis - isolation & purification ; Radiography ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - blood ; Tuberculosis, Pulmonary - complications ; Tuberculosis, Pulmonary - diagnosis ; Tuberculosis, Pulmonary - diagnostic imaging ; Tuberculosis, Pulmonary - pathology</subject><ispartof>The Lancet infectious diseases, 2006-07, Vol.6 (7), p.447-454</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jul 2006</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-a3d8f942bc4c19480a24664c6601acd78c08148de1fb03d9a0a1569dd111c3c43</citedby><cites>FETCH-LOGICAL-c472t-a3d8f942bc4c19480a24664c6601acd78c08148de1fb03d9a0a1569dd111c3c43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/201612930?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17842749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16790385$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brastianos, Priscilla K</creatorcontrib><creatorcontrib>Swanson, Jordan W</creatorcontrib><creatorcontrib>Torbenson, Michael</creatorcontrib><creatorcontrib>Sperati, John</creatorcontrib><creatorcontrib>Karakousis, Petros C</creatorcontrib><title>Tuberculosis-associated haemophagocytic syndrome</title><title>The Lancet infectious diseases</title><addtitle>Lancet Infect Dis</addtitle><description>Haemophagocytic syndrome is a disorder characterised by fevers, lymphadenopathy, hepatosplenomegaly, cytopenias, and hyperferritinaemia due to dysregulated activation and proliferation of macrophages, leading to uncontrolled phagocytosis of platelets, erythrocytes, lymphocytes, and their haematopoietic precursors throughout the reticuloendothelial system. Primary or familial haemophagocytic syndrome appears to have a genetic aetiology, whereas secondary haemophagocytic syndrome may be associated with malignancy, autoimmune disease, or infection. Epstein-Barr virus is the most common infectious aetiology implicated in haemophagocytic syndrome, but the syndrome has been associated with a variety of other viral, bacterial, and parasitic pathogens. We describe a case of haemophagocytic syndrome associated with disseminated
Mycobacterium tuberculosis. We review all cases of
M tuberculosis-associated haemophagocytic syndrome reported in the English language literature and discuss important issues pertaining to the epidemiology, diagnosis, and management of this disease.</description><subject>Abdominal Pain - etiology</subject><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Blood Cell Count</subject><subject>Diagnosis, Differential</subject><subject>Epidemiology</subject><subject>Etiology</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Lymphocytes</subject><subject>Lymphohistiocytosis, Hemophagocytic - blood</subject><subject>Lymphohistiocytosis, Hemophagocytic - complications</subject><subject>Lymphohistiocytosis, Hemophagocytic - diagnosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Radiography</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - 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Academic</collection><jtitle>The Lancet infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brastianos, Priscilla K</au><au>Swanson, Jordan W</au><au>Torbenson, Michael</au><au>Sperati, John</au><au>Karakousis, Petros C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tuberculosis-associated haemophagocytic syndrome</atitle><jtitle>The Lancet infectious diseases</jtitle><addtitle>Lancet Infect Dis</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>6</volume><issue>7</issue><spage>447</spage><epage>454</epage><pages>447-454</pages><issn>1473-3099</issn><eissn>1474-4457</eissn><coden>LANCAO</coden><abstract>Haemophagocytic syndrome is a disorder characterised by fevers, lymphadenopathy, hepatosplenomegaly, cytopenias, and hyperferritinaemia due to dysregulated activation and proliferation of macrophages, leading to uncontrolled phagocytosis of platelets, erythrocytes, lymphocytes, and their haematopoietic precursors throughout the reticuloendothelial system. Primary or familial haemophagocytic syndrome appears to have a genetic aetiology, whereas secondary haemophagocytic syndrome may be associated with malignancy, autoimmune disease, or infection. Epstein-Barr virus is the most common infectious aetiology implicated in haemophagocytic syndrome, but the syndrome has been associated with a variety of other viral, bacterial, and parasitic pathogens. We describe a case of haemophagocytic syndrome associated with disseminated
Mycobacterium tuberculosis. We review all cases of
M tuberculosis-associated haemophagocytic syndrome reported in the English language literature and discuss important issues pertaining to the epidemiology, diagnosis, and management of this disease.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>16790385</pmid><doi>10.1016/S1473-3099(06)70524-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Lancet infectious diseases, 2006-07, Vol.6 (7), p.447-454 |
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| subjects | Abdominal Pain - etiology Adult Bacterial diseases Biological and medical sciences Blood Cell Count Diagnosis, Differential Epidemiology Etiology Human bacterial diseases Humans Infectious diseases Lymphocytes Lymphohistiocytosis, Hemophagocytic - blood Lymphohistiocytosis, Hemophagocytic - complications Lymphohistiocytosis, Hemophagocytic - diagnosis Male Medical sciences Mycobacterium tuberculosis - isolation & purification Radiography Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - blood Tuberculosis, Pulmonary - complications Tuberculosis, Pulmonary - diagnosis Tuberculosis, Pulmonary - diagnostic imaging Tuberculosis, Pulmonary - pathology |
| title | Tuberculosis-associated haemophagocytic syndrome |
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