Urothelial CD44 Facilitates Escherichia coli Infection of the Murine Urinary Tract

Escherichia coli is the most common pathogen found in urinary tract infections (UTIs), mainly affecting children and women. We report that CD44, a hyaluronic acid (HA) binding protein that mediates cell-cell and cell-matrix interactions, facilitates the interaction of E. coli with urothelial cells a...

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Veröffentlicht in:	Journal of Immunology 2006-11, Vol.177 (10), p.7225-7232
Hauptverfasser:	Rouschop, Kasper M. A, Sylva, Marc, Teske, Gwendoline J. D, Hoedemaeker, Inge, Pals, Steven T, Weening, Jan J, van der Poll, Tom, Florquin, Sandrine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Adhesion - immunology Bacterial Translocation - immunology Chemokines - biosynthesis Colony Count, Microbial Cytokines - biosynthesis Escherichia coli Escherichia coli Infections - genetics Escherichia coli Infections - immunology Escherichia coli Infections - microbiology Escherichia coli Infections - pathology Female Hyaluronan Receptors - biosynthesis Hyaluronan Receptors - genetics Hyaluronan Receptors - physiology Hyaluronic Acid - physiology Inflammation Mediators - metabolism Kidney Tubules - microbiology Mice Mice, Inbred C57BL Mice, Knockout Neutrophil Infiltration - genetics Neutrophil Infiltration - immunology Phagocytosis - genetics Phagocytosis - immunology Urinary Tract Infections - genetics Urinary Tract Infections - immunology Urinary Tract Infections - microbiology Urinary Tract Infections - pathology Urothelium - cytology Urothelium - immunology Urothelium - metabolism
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