A common human TLR1 polymorphism regulates the innate immune response to lipopeptides

Toll‐like receptors (TLR) are critical mediators of the immune response to pathogens and human polymorphisms in this gene family regulate inflammatory pathways and are associated with susceptibility to infection. Lipopeptides are present in a wide variety of microbes and stimulate immune responses t...

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Veröffentlicht in:	European Journal of Immunology 2007-08, Vol.37 (8), p.2280-2289
Hauptverfasser:	Hawn, Thomas R., Misch, E. Ann, Dunstan, Sarah J., Thwaites, Guy E., Lan, Nguyen T. N., Quy, Hoang T., Chau, Tran T. H., Rodrigues, Stephanie, Nachman, Alex, Janer, Marta, Hien, Tran T., Farrar, Jeremy J., Aderem, Alan
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - immunology Base Sequence Fluorescent Antibody Technique Genetics Humans Immunity, Innate Immunoblotting Infectious diseases Inflammation Innate immunity Lipoproteins - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology NF-kappa B Polymerase Chain Reaction Polymorphism, Single Nucleotide Toll-Like Receptor 1 - genetics Transfection
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