Inhibition of forkhead box class O family member transcription factors in rheumatoid synovial tissue

Objective Phosphatidylinositol 3‐kinase–dependent activation of protein kinase B (PKB) has been observed in rheumatoid arthritis (RA) synovial tissue, and mechanisms that interfere with this process are protective in animal models of arthritis. PKB can regulate cell survival and proliferation via ph...

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Veröffentlicht in:	Arthritis and rheumatism 2007-07, Vol.56 (7), p.2180-2191
Hauptverfasser:	Ludikhuize, J., de Launay, D., Groot, D., Smeets, T. J. M., Vinkenoog, M., Sanders, M. E., Tas, S. W., Tak, P. P., Reedquist, K. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology Biological and medical sciences Biopsy Blood Sedimentation Diseases of the osteoarticular system Female Fibroblasts - physiology Forkhead Box Protein O1 Forkhead Transcription Factors - antagonists & inhibitors Goats Humans Immunohistochemistry Inflammatory joint diseases Macrophages - pathology Male Medical sciences Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Osteoarthritis Osteoarthritis - blood Osteoarthritis - genetics Osteoarthritis - pathology Phosphorylation Rabbits Synovial Membrane - pathology
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