Striatal gray matter loss in Huntington's disease is leftward biased
In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐h...
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| Veröffentlicht in: | Movement disorders 2007-06, Vol.22 (8), p.1169-1173 |
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| creator | Mühlau, Mark Gaser, Christian Wohlschläger, Afra M. Weindl, Adolf Städtler, Michael Valet, Michael Zimmer, Claus Kassubek, Jan Peinemann, Alexander |
| description | In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society |
| doi_str_mv | 10.1002/mds.21137 |
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Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.21137</identifier><identifier>PMID: 17394246</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Brain - pathology ; Cognition Disorders - diagnosis ; Cognition Disorders - epidemiology ; Corpus Striatum - pathology ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Functional Laterality - physiology ; gray matter loss ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Huntington Disease - diagnosis ; Huntington Disease - epidemiology ; Huntington Disease - pathology ; Huntington's disease ; lateralization ; lateralization, striatum ; Male ; Medical sciences ; Middle Aged ; Nerve Degeneration - epidemiology ; Nerve Degeneration - pathology ; Nervous system (semeiology, syndromes) ; Neurology ; Neuropsychological Tests ; Severity of Illness Index ; striatum ; voxel-based morphometry</subject><ispartof>Movement disorders, 2007-06, Vol.22 (8), p.1169-1173</ispartof><rights>Copyright © 2007 Movement Disorder Society</rights><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4887-444328a7c79efe83df2fca1866ff4f1d5569c83248f8c0ac7f31f85241a012553</citedby><cites>FETCH-LOGICAL-c4887-444328a7c79efe83df2fca1866ff4f1d5569c83248f8c0ac7f31f85241a012553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.21137$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.21137$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18883329$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17394246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mühlau, Mark</creatorcontrib><creatorcontrib>Gaser, Christian</creatorcontrib><creatorcontrib>Wohlschläger, Afra M.</creatorcontrib><creatorcontrib>Weindl, Adolf</creatorcontrib><creatorcontrib>Städtler, Michael</creatorcontrib><creatorcontrib>Valet, Michael</creatorcontrib><creatorcontrib>Zimmer, Claus</creatorcontrib><creatorcontrib>Kassubek, Jan</creatorcontrib><creatorcontrib>Peinemann, Alexander</creatorcontrib><title>Striatal gray matter loss in Huntington's disease is leftward biased</title><title>Movement disorders</title><addtitle>Mov. Disord</addtitle><description>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. Our study demonstrates and discusses leftward‐biased gray matter loss in HD. © 2007 Movement Disorder Society</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Brain - pathology</subject><subject>Cognition Disorders - diagnosis</subject><subject>Cognition Disorders - epidemiology</subject><subject>Corpus Striatum - pathology</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>gray matter loss</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Huntington Disease - diagnosis</subject><subject>Huntington Disease - epidemiology</subject><subject>Huntington Disease - pathology</subject><subject>Huntington's disease</subject><subject>lateralization</subject><subject>lateralization, striatum</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Degeneration - epidemiology</subject><subject>Nerve Degeneration - pathology</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Severity of Illness Index</subject><subject>striatum</subject><subject>voxel-based morphometry</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0D1vFDEQBmALgcgRKPgDyA1BFJt4_LGeLVE-LogNFAEhpbEcrx0ZdveC7VO4f4_hDlJFVJZGz7wjv4S8BHYIjPGjaciHHEDoR2QBSkCDXOnHZMEQVSMA1R55lvM3xgAUtE_JHmjRSS7bBTm5LCnaYkd6k-yGTrYUn-i4ypnGmZ6v5xLnm7Ka32Q6xOxt9jRmOvpQ7mwa6HWsk-E5eRLsmP2L3btPvpydfj4-b_pPy_fH7_rGSUTdSCkFR6ud7nzwKIbAg7OAbRuCDDAo1XYOBZcY0DHrdBAQUHEJlgFXSuyTg23ubVr9WPtczBSz8-NoZ79aZ9MisJrB_wtrWapjXFT4dgtdql9OPpjbFCebNgaY-d2tqd2aP91W-2oXur6e_HAvd2VW8HoHbHZ2DMnOLuZ7h4hC8K66o627i6PfPHzRXJxc_j3dbDdiLv7nvw2bvptWC63M149L06vl1dVZ35sP4heo-54A</recordid><startdate>20070615</startdate><enddate>20070615</enddate><creator>Mühlau, Mark</creator><creator>Gaser, Christian</creator><creator>Wohlschläger, Afra M.</creator><creator>Weindl, Adolf</creator><creator>Städtler, Michael</creator><creator>Valet, Michael</creator><creator>Zimmer, Claus</creator><creator>Kassubek, Jan</creator><creator>Peinemann, Alexander</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20070615</creationdate><title>Striatal gray matter loss in Huntington's disease is leftward biased</title><author>Mühlau, Mark ; Gaser, Christian ; Wohlschläger, Afra M. ; Weindl, Adolf ; Städtler, Michael ; Valet, Michael ; Zimmer, Claus ; Kassubek, Jan ; Peinemann, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4887-444328a7c79efe83df2fca1866ff4f1d5569c83248f8c0ac7f31f85241a012553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Brain - pathology</topic><topic>Cognition Disorders - diagnosis</topic><topic>Cognition Disorders - epidemiology</topic><topic>Corpus Striatum - pathology</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>gray matter loss</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. 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Disord</addtitle><date>2007-06-15</date><risdate>2007</risdate><volume>22</volume><issue>8</issue><spage>1169</spage><epage>1173</epage><pages>1169-1173</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>In Huntington's disease (HD), the distribution of pathological changes throughout the brain is incompletely understood. Some studies have identified leftward‐biased lateralization, whereas others did not. We performed magnetic resonance imaging and a voxel‐based asymmetry analysis in 44 right‐handed HD gene carriers (presymptomatic, n = 5; stage I, n = 28; stage II, n = 11) and 44 right‐handed healthy controls. The group comparison revealed leftward‐biased gray matter loss in the striatum. Further analyses showed no indication of asymmetry in presymptomatic HD patients but an increase in asymmetry in the course of the HD stages under examination. 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| subjects | Adult Aged Biological and medical sciences Brain - pathology Cognition Disorders - diagnosis Cognition Disorders - epidemiology Corpus Striatum - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Functional Laterality - physiology gray matter loss Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Huntington Disease - diagnosis Huntington Disease - epidemiology Huntington Disease - pathology Huntington's disease lateralization lateralization, striatum Male Medical sciences Middle Aged Nerve Degeneration - epidemiology Nerve Degeneration - pathology Nervous system (semeiology, syndromes) Neurology Neuropsychological Tests Severity of Illness Index striatum voxel-based morphometry |
| title | Striatal gray matter loss in Huntington's disease is leftward biased |
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