Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy

Differential expression of GABA(A) receptor (GABR) subunits has been demonstrated in hippocampus from patients and animals with temporal lobe epilepsy (TLE), but whether these changes are important for epileptogenesis remains unknown. Previous studies in the adult rat pilocarpine model of TLE found...

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Veröffentlicht in:	The Journal of neuroscience 2006-11, Vol.26 (44), p.11342-11346
Hauptverfasser:	Raol, YogendraSinh H, Lund, Ingrid V, Bandyopadhyay, Sabita, Zhang, Guojun, Roberts, Daniel S, Wolfe, John H, Russek, Shelley J, Brooks-Kayal, Amy R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Epilepsy, Temporal Lobe - genetics Epilepsy, Temporal Lobe - metabolism Epilepsy, Temporal Lobe - prevention & control Genetic Vectors - genetics Humans Male Neural Inhibition - physiology Parahippocampal Gyrus - metabolism Protein Subunits - biosynthesis Protein Subunits - genetics Protein Subunits - metabolism Rats Rats, Sprague-Dawley Receptors, GABA-A - biosynthesis Receptors, GABA-A - genetics Receptors, GABA-A - metabolism
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