Interferon-alpha differentially rescues CD4 and CD8 T cells from apoptosis in HIV infection

To examine the effects of interferon-alpha (IFN-alpha) on T cell survival and activation in HIV infection. The effects of IFN-alpha on spontaneous apoptosis and CD38 expression among T cell subsets were determined in vitro and studied in relation to CD4 cell counts, plasma HIV RNA levels and the age...

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Veröffentlicht in:	AIDS (London) 2006-06, Vol.20 (10), p.1379-1389
Hauptverfasser:	Rodriguez, Benigno, Lederman, Michael M, Jiang, Wei, Bazdar, Douglas A, Gàrate, Kristen, Harding, Clifford V, Sieg, Scott F
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP-ribosyl Cyclase 1 - analysis Adult AIDS/HIV Apoptosis - drug effects CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - pathology Cells, Cultured HIV Infections - immunology HIV Infections - virology HIV-1 - drug effects HIV-1 - isolation & purification Human immunodeficiency virus Humans Interferon-alpha - pharmacology Leukocyte Common Antigens - analysis Lymphocyte Activation - immunology Middle Aged Recombinant Proteins RNA, Viral - blood
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