Cyclin D1 and epidermal growth factor polymorphisms associated with survival in patients with advanced colorectal cancer treated with Cetuximab

The study aimed to investigate whether polymorphisms in genes of the EGFR signaling pathway are associated with clinical outcome in advanced colorectal cancer (CRC) patients treated with single-agent Cetuximab. Polymorphisms of interest in the EGFR pathway includecyclin D1 (CCND1) A870G, cyclooxygen...

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Veröffentlicht in:	Pharmacogenetics and genomics 2006-07, Vol.16 (7), p.475-483
Hauptverfasser:	Zhang, Wu, Gordon, Michael, Press, Oliver A, Rhodes, Katrin, Vallböhmer, Daniel, Yang, Dong Yun, Park, David, Fazzone, William, Schultheis, Anne, Sherrod, Andy E, Iqbal, Syma, Groshen, Susan, Lenz, Heinz-Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Cetuximab Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease Progression Drug Resistance, Neoplasm - genetics Epidermal Growth Factor - genetics Female Genes, bcl-1 - genetics Humans Male Middle Aged Neoplasm Staging Pilot Projects Polymorphism, Genetic Survival Analysis
Online-Zugang:	Volltext
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