BioGlue®: A Protective Barrier After Pericardiotomy
Background: Repeat operation on the heart composes about 20% of procedures in contemporary practice of cardiac surgery. A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. Methods: Anterior pericardiectomy was performed in rats. BioGlue® milled to a 0....
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| Veröffentlicht in: | Journal of cardiac surgery 2007-07, Vol.22 (4), p.295-299 |
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| creator | Wang, Nai Dong Doty, Donald B. Doty, John R. Yuksel, Umit Flinner, Robert |
| description | Background: Repeat operation on the heart composes about 20% of procedures in contemporary practice of cardiac surgery. A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. Methods: Anterior pericardiectomy was performed in rats. BioGlue® milled to a 0.4 mm sheet was applied to the anterior surface of the heart in 16 rats; Surgicel® plus liquid BioGlue® in seven; Surgicel alone in three; and nothing (control) in eight. The operative site was reexamined for gross evidence of adhesion, scarring, and residual BioGlue® 1, 3, and 6 months later. Results: There was formation of a loose connective tissue barrier containing blood vessels without scar formation in all animals treated with milled BioGlue®. Surgicel® plus BioGlue® resulted in a barrier containing more denser connective tissue with collagen fibers. Surgicel® alone resulted in a similar barrier. No barrier formed in the control experiments. Conclusions: A sheet of milled BioGlue® applied over the surface of the heart but not attached to it after partial pericardiectomy has been shown to stimulate formation of a loose connective tissue barrier containing blood vessels. This barrier is unique compared to dense fibrous scar which usually forms after opening the pericardium for cardiac operations. |
| doi_str_mv | 10.1111/j.1540-8191.2007.00410.x |
| format | Article |
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A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. Methods: Anterior pericardiectomy was performed in rats. BioGlue® milled to a 0.4 mm sheet was applied to the anterior surface of the heart in 16 rats; Surgicel® plus liquid BioGlue® in seven; Surgicel alone in three; and nothing (control) in eight. The operative site was reexamined for gross evidence of adhesion, scarring, and residual BioGlue® 1, 3, and 6 months later. Results: There was formation of a loose connective tissue barrier containing blood vessels without scar formation in all animals treated with milled BioGlue®. Surgicel® plus BioGlue® resulted in a barrier containing more denser connective tissue with collagen fibers. Surgicel® alone resulted in a similar barrier. No barrier formed in the control experiments. Conclusions: A sheet of milled BioGlue® applied over the surface of the heart but not attached to it after partial pericardiectomy has been shown to stimulate formation of a loose connective tissue barrier containing blood vessels. This barrier is unique compared to dense fibrous scar which usually forms after opening the pericardium for cardiac operations.</description><identifier>ISSN: 0886-0440</identifier><identifier>EISSN: 1540-8191</identifier><identifier>DOI: 10.1111/j.1540-8191.2007.00410.x</identifier><identifier>PMID: 17661769</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Animals ; Cellulose, Oxidized ; Collagen - metabolism ; Connective Tissue - blood supply ; Connective Tissue - pathology ; Male ; Pericardiectomy - methods ; Pericardium - pathology ; Postoperative Complications - pathology ; Postoperative Complications - prevention & control ; Prostheses and Implants ; Proteins - administration & dosage ; Rats ; Rats, Long-Evans ; Reoperation ; Tissue Adhesions - pathology ; Tissue Adhesions - prevention & control ; Wound Healing - physiology</subject><ispartof>Journal of cardiac surgery, 2007-07, Vol.22 (4), p.295-299</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4550-329d3d4fef293c47ec0a93d88665be8eee6b3b67cad0e541c955db1f975365233</citedby><cites>FETCH-LOGICAL-c4550-329d3d4fef293c47ec0a93d88665be8eee6b3b67cad0e541c955db1f975365233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1540-8191.2007.00410.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1540-8191.2007.00410.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17661769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Nai Dong</creatorcontrib><creatorcontrib>Doty, Donald B.</creatorcontrib><creatorcontrib>Doty, John R.</creatorcontrib><creatorcontrib>Yuksel, Umit</creatorcontrib><creatorcontrib>Flinner, Robert</creatorcontrib><title>BioGlue®: A Protective Barrier After Pericardiotomy</title><title>Journal of cardiac surgery</title><addtitle>J Card Surg</addtitle><description>Background: Repeat operation on the heart composes about 20% of procedures in contemporary practice of cardiac surgery. A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. Methods: Anterior pericardiectomy was performed in rats. BioGlue® milled to a 0.4 mm sheet was applied to the anterior surface of the heart in 16 rats; Surgicel® plus liquid BioGlue® in seven; Surgicel alone in three; and nothing (control) in eight. The operative site was reexamined for gross evidence of adhesion, scarring, and residual BioGlue® 1, 3, and 6 months later. Results: There was formation of a loose connective tissue barrier containing blood vessels without scar formation in all animals treated with milled BioGlue®. Surgicel® plus BioGlue® resulted in a barrier containing more denser connective tissue with collagen fibers. Surgicel® alone resulted in a similar barrier. No barrier formed in the control experiments. Conclusions: A sheet of milled BioGlue® applied over the surface of the heart but not attached to it after partial pericardiectomy has been shown to stimulate formation of a loose connective tissue barrier containing blood vessels. This barrier is unique compared to dense fibrous scar which usually forms after opening the pericardium for cardiac operations.</description><subject>Animals</subject><subject>Cellulose, Oxidized</subject><subject>Collagen - metabolism</subject><subject>Connective Tissue - blood supply</subject><subject>Connective Tissue - pathology</subject><subject>Male</subject><subject>Pericardiectomy - methods</subject><subject>Pericardium - pathology</subject><subject>Postoperative Complications - pathology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Prostheses and Implants</subject><subject>Proteins - administration & dosage</subject><subject>Rats</subject><subject>Rats, Long-Evans</subject><subject>Reoperation</subject><subject>Tissue Adhesions - pathology</subject><subject>Tissue Adhesions - prevention & control</subject><subject>Wound Healing - physiology</subject><issn>0886-0440</issn><issn>1540-8191</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAQhi0EgrK8AsqJW8o4XhIjcSgVlE1QiU3iYiXORHJJSbFTaF-Kh-DJcGkFVyx5keb_xvZHSEShS8M4HHWp4BBnVNFuApB2AXiozdZI57ewTjqQZTIGzmGLbHs_AkgSzmCTbNFUyjBVh_AT2wzqKX59HkW9aOiaFk1r3zE6yZ2z6KJe1YZ1iM6a3JW2aZvxfJdsVHntcW-175CHs9P7_nl8fTu46PeuY8OFgJglqmQlr7BKFDM8RQO5YmV4lBQFZogoC1bI1OQloODUKCHKglYqFUyKhLEdcrDsO3HN2xR9q8fWG6zr_BWbqdcyo-HjoEIwWwaNa7x3WOmJs-PczTUFvTCmR3ohRi_E6IUx_WNMzwK6v7pjWoyx_ANXikLgeBn4sDXO_91YX97278Ip8PGSt77F2S-fuxctU5YK_XQz0FeD5_Ph82OqFfsGTsuIdQ</recordid><startdate>200707</startdate><enddate>200707</enddate><creator>Wang, Nai Dong</creator><creator>Doty, Donald B.</creator><creator>Doty, John R.</creator><creator>Yuksel, Umit</creator><creator>Flinner, Robert</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200707</creationdate><title>BioGlue®: A Protective Barrier After Pericardiotomy</title><author>Wang, Nai Dong ; Doty, Donald B. ; Doty, John R. ; Yuksel, Umit ; Flinner, Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4550-329d3d4fef293c47ec0a93d88665be8eee6b3b67cad0e541c955db1f975365233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Cellulose, Oxidized</topic><topic>Collagen - metabolism</topic><topic>Connective Tissue - blood supply</topic><topic>Connective Tissue - pathology</topic><topic>Male</topic><topic>Pericardiectomy - methods</topic><topic>Pericardium - pathology</topic><topic>Postoperative Complications - pathology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Prostheses and Implants</topic><topic>Proteins - administration & dosage</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Reoperation</topic><topic>Tissue Adhesions - pathology</topic><topic>Tissue Adhesions - prevention & control</topic><topic>Wound Healing - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Nai Dong</creatorcontrib><creatorcontrib>Doty, Donald B.</creatorcontrib><creatorcontrib>Doty, John R.</creatorcontrib><creatorcontrib>Yuksel, Umit</creatorcontrib><creatorcontrib>Flinner, Robert</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiac surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Nai Dong</au><au>Doty, Donald B.</au><au>Doty, John R.</au><au>Yuksel, Umit</au><au>Flinner, Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BioGlue®: A Protective Barrier After Pericardiotomy</atitle><jtitle>Journal of cardiac surgery</jtitle><addtitle>J Card Surg</addtitle><date>2007-07</date><risdate>2007</risdate><volume>22</volume><issue>4</issue><spage>295</spage><epage>299</epage><pages>295-299</pages><issn>0886-0440</issn><eissn>1540-8191</eissn><abstract>Background: Repeat operation on the heart composes about 20% of procedures in contemporary practice of cardiac surgery. A sheet of material providing a barrier against cardiac adhesion to the sternum would be desirable. Methods: Anterior pericardiectomy was performed in rats. BioGlue® milled to a 0.4 mm sheet was applied to the anterior surface of the heart in 16 rats; Surgicel® plus liquid BioGlue® in seven; Surgicel alone in three; and nothing (control) in eight. The operative site was reexamined for gross evidence of adhesion, scarring, and residual BioGlue® 1, 3, and 6 months later. Results: There was formation of a loose connective tissue barrier containing blood vessels without scar formation in all animals treated with milled BioGlue®. Surgicel® plus BioGlue® resulted in a barrier containing more denser connective tissue with collagen fibers. Surgicel® alone resulted in a similar barrier. No barrier formed in the control experiments. Conclusions: A sheet of milled BioGlue® applied over the surface of the heart but not attached to it after partial pericardiectomy has been shown to stimulate formation of a loose connective tissue barrier containing blood vessels. This barrier is unique compared to dense fibrous scar which usually forms after opening the pericardium for cardiac operations.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>17661769</pmid><doi>10.1111/j.1540-8191.2007.00410.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Animals Cellulose, Oxidized Collagen - metabolism Connective Tissue - blood supply Connective Tissue - pathology Male Pericardiectomy - methods Pericardium - pathology Postoperative Complications - pathology Postoperative Complications - prevention & control Prostheses and Implants Proteins - administration & dosage Rats Rats, Long-Evans Reoperation Tissue Adhesions - pathology Tissue Adhesions - prevention & control Wound Healing - physiology |
| title | BioGlue®: A Protective Barrier After Pericardiotomy |
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