MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation
A new technique is demonstrated in six healthy human subjects that combines grid‐tagging and hyperpolarized helium‐3 MRI to assess regional lung biomechanical function and quantitative ventilation. 2D grid‐tagging, achieved by applying sinc‐modulated RF‐pulse trains along the frequency‐ and phase‐en...
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| Veröffentlicht in: | Magnetic resonance in medicine 2007-08, Vol.58 (2), p.373-380 |
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| creator | Cai, J. Altes, T.A. Miller, G.W. Sheng, K. Read, P.W. Mata, J.F. Zhong, X. Cates Jr, G.D. de Lange, E.E. Mugler III, J.P. Brookeman, J.R. |
| description | A new technique is demonstrated in six healthy human subjects that combines grid‐tagging and hyperpolarized helium‐3 MRI to assess regional lung biomechanical function and quantitative ventilation. 2D grid‐tagging, achieved by applying sinc‐modulated RF‐pulse trains along the frequency‐ and phase‐encoding directions, was followed by a multislice fast low‐angle shot (FLASH)‐based acquisition at inspiration and expiration. The displacement vectors, first and second principal strains, and quantitative ventilation were computed, and mean values were calculated for the upper, middle, and lower lung regions. Displacements in the lower region were significantly greater than those in either the middle or upper region (P < 0.005), while there were no significant differences between the three regions for the two principal strains and quantitative ventilation (P = 0.11–0.92). Variations in principal strains and ventilation were greater between subjects than between lung zones within individual subjects. This technique has the potential to provide insight into regional biomechanical alterations of lung function in a variety of lung diseases. Magn Reson Med 58:373–380, 2007. © 2007 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.21288 |
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The displacement vectors, first and second principal strains, and quantitative ventilation were computed, and mean values were calculated for the upper, middle, and lower lung regions. Displacements in the lower region were significantly greater than those in either the middle or upper region (P < 0.005), while there were no significant differences between the three regions for the two principal strains and quantitative ventilation (P = 0.11–0.92). Variations in principal strains and ventilation were greater between subjects than between lung zones within individual subjects. This technique has the potential to provide insight into regional biomechanical alterations of lung function in a variety of lung diseases. Magn Reson Med 58:373–380, 2007. © 2007 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.21288</identifier><identifier>PMID: 17654579</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Algorithms ; Biomechanical Phenomena ; Female ; grid-tagging ; Helium ; Humans ; hyperpolarized 3He ; Isotopes ; lung deformation ; lung ventilation ; Magnetic Resonance Imaging - methods ; Male ; pulmonary biomechanics ; Pulmonary Ventilation - physiology ; Respiratory Function Tests ; Respiratory Mechanics</subject><ispartof>Magnetic resonance in medicine, 2007-08, Vol.58 (2), p.373-380</ispartof><rights>Copyright © 2007 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4278-eacfede4fb30a2fc75c9e502766f820cd0537c79c8baed8557a472749e436a243</citedby><cites>FETCH-LOGICAL-c4278-eacfede4fb30a2fc75c9e502766f820cd0537c79c8baed8557a472749e436a243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.21288$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.21288$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17654579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, J.</creatorcontrib><creatorcontrib>Altes, T.A.</creatorcontrib><creatorcontrib>Miller, G.W.</creatorcontrib><creatorcontrib>Sheng, K.</creatorcontrib><creatorcontrib>Read, P.W.</creatorcontrib><creatorcontrib>Mata, J.F.</creatorcontrib><creatorcontrib>Zhong, X.</creatorcontrib><creatorcontrib>Cates Jr, G.D.</creatorcontrib><creatorcontrib>de Lange, E.E.</creatorcontrib><creatorcontrib>Mugler III, J.P.</creatorcontrib><creatorcontrib>Brookeman, J.R.</creatorcontrib><title>MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>A new technique is demonstrated in six healthy human subjects that combines grid‐tagging and hyperpolarized helium‐3 MRI to assess regional lung biomechanical function and quantitative ventilation. 2D grid‐tagging, achieved by applying sinc‐modulated RF‐pulse trains along the frequency‐ and phase‐encoding directions, was followed by a multislice fast low‐angle shot (FLASH)‐based acquisition at inspiration and expiration. The displacement vectors, first and second principal strains, and quantitative ventilation were computed, and mean values were calculated for the upper, middle, and lower lung regions. Displacements in the lower region were significantly greater than those in either the middle or upper region (P < 0.005), while there were no significant differences between the three regions for the two principal strains and quantitative ventilation (P = 0.11–0.92). Variations in principal strains and ventilation were greater between subjects than between lung zones within individual subjects. This technique has the potential to provide insight into regional biomechanical alterations of lung function in a variety of lung diseases. Magn Reson Med 58:373–380, 2007. © 2007 Wiley‐Liss, Inc.</description><subject>Adult</subject><subject>Algorithms</subject><subject>Biomechanical Phenomena</subject><subject>Female</subject><subject>grid-tagging</subject><subject>Helium</subject><subject>Humans</subject><subject>hyperpolarized 3He</subject><subject>Isotopes</subject><subject>lung deformation</subject><subject>lung ventilation</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>pulmonary biomechanics</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Respiratory Function Tests</subject><subject>Respiratory Mechanics</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCgT-AfELikNbxR2wfUQst0i4fVRFHy-tMsgY7Se2kdBE_niy7wAlxmbk87yPNvAg9K8lpSQg9iyme0pIq9QAtSkFpQYXmD9GCSE4KVmp-hI5z_kII0Vryx-iolJXgQuoF-rG6xm3ydTHatvVdi6e8m5vtAGnog03-O9R4A8FPsWC46RNO0Pq-swHfTrYb_WhHfwfY5gw5R-hG3Dd4mEKcmbTFa99HcBvbeZex7Wp8NyM-zKG-e4IeNTZkeHrYJ-jTm9c351fF8v3l2_NXy8JxKlUB1jVQA2_WjFjaOCmcBkGorKpGUeJqIph0Uju1tlArIaTlkkqugbPKUs5O0Iu9d0j97QR5NNFnByHYDvopm0rt3qjL_4KUKMErwmbw5R50qc85QWOG5ON8rymJ2cnM3In51cnMPj9Ip3WE-i95KGEGzvbANx9g-2-TWV2vfiuLfcLnEe7_JGz6airJpDCf312aq5sPF6ul-mgk-wnyY6hJ</recordid><startdate>200708</startdate><enddate>200708</enddate><creator>Cai, J.</creator><creator>Altes, T.A.</creator><creator>Miller, G.W.</creator><creator>Sheng, K.</creator><creator>Read, P.W.</creator><creator>Mata, J.F.</creator><creator>Zhong, X.</creator><creator>Cates Jr, G.D.</creator><creator>de Lange, E.E.</creator><creator>Mugler III, J.P.</creator><creator>Brookeman, J.R.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200708</creationdate><title>MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation</title><author>Cai, J. ; Altes, T.A. ; Miller, G.W. ; Sheng, K. ; Read, P.W. ; Mata, J.F. ; Zhong, X. ; Cates Jr, G.D. ; de Lange, E.E. ; Mugler III, J.P. ; Brookeman, J.R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4278-eacfede4fb30a2fc75c9e502766f820cd0537c79c8baed8557a472749e436a243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Algorithms</topic><topic>Biomechanical Phenomena</topic><topic>Female</topic><topic>grid-tagging</topic><topic>Helium</topic><topic>Humans</topic><topic>hyperpolarized 3He</topic><topic>Isotopes</topic><topic>lung deformation</topic><topic>lung ventilation</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>pulmonary biomechanics</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Respiratory Function Tests</topic><topic>Respiratory Mechanics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, J.</creatorcontrib><creatorcontrib>Altes, T.A.</creatorcontrib><creatorcontrib>Miller, G.W.</creatorcontrib><creatorcontrib>Sheng, K.</creatorcontrib><creatorcontrib>Read, P.W.</creatorcontrib><creatorcontrib>Mata, J.F.</creatorcontrib><creatorcontrib>Zhong, X.</creatorcontrib><creatorcontrib>Cates Jr, G.D.</creatorcontrib><creatorcontrib>de Lange, E.E.</creatorcontrib><creatorcontrib>Mugler III, J.P.</creatorcontrib><creatorcontrib>Brookeman, J.R.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, J.</au><au>Altes, T.A.</au><au>Miller, G.W.</au><au>Sheng, K.</au><au>Read, P.W.</au><au>Mata, J.F.</au><au>Zhong, X.</au><au>Cates Jr, G.D.</au><au>de Lange, E.E.</au><au>Mugler III, J.P.</au><au>Brookeman, J.R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2007-08</date><risdate>2007</risdate><volume>58</volume><issue>2</issue><spage>373</spage><epage>380</epage><pages>373-380</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>A new technique is demonstrated in six healthy human subjects that combines grid‐tagging and hyperpolarized helium‐3 MRI to assess regional lung biomechanical function and quantitative ventilation. 2D grid‐tagging, achieved by applying sinc‐modulated RF‐pulse trains along the frequency‐ and phase‐encoding directions, was followed by a multislice fast low‐angle shot (FLASH)‐based acquisition at inspiration and expiration. The displacement vectors, first and second principal strains, and quantitative ventilation were computed, and mean values were calculated for the upper, middle, and lower lung regions. 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| subjects | Adult Algorithms Biomechanical Phenomena Female grid-tagging Helium Humans hyperpolarized 3He Isotopes lung deformation lung ventilation Magnetic Resonance Imaging - methods Male pulmonary biomechanics Pulmonary Ventilation - physiology Respiratory Function Tests Respiratory Mechanics |
| title | MR grid-tagging using hyperpolarized helium-3 for regional quantitative assessment of pulmonary biomechanics and ventilation |
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