Lysophosphatidylcholine produced by the phospholipase A2 isolated from Lachesis muta snake venom modulates natural killer activity as a protein kinase C effector

We have showed that a phospholipase A(2) isolated from Lachesis muta snake venom, denoted LM-PLA(2)-I, had some biological effects. Here, we examined its effects on lymphocytes. Pre-incubation of human peripheral blood lymphocytes with LM-PLA(2)-I plus phosphatidylcholine (PC) stimulated the natural...

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Veröffentlicht in:	Toxicon (Oxford) 2007-09, Vol.50 (3), p.400-410
Hauptverfasser:	FULY, André L, MACHADO, Alexandre L, CASTRO, Paulo, ABRAHAO, Agessandro, REDNER, Paulo, LOPES, Ulisses G, GUIMARAES, Jorge A, KOATZ, Vera Lucia G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal poisons toxicology. Antivenoms Animals Biological and medical sciences Cell Line, Tumor Crotalid Venoms - chemistry Crotalid Venoms - enzymology Humans Killer Cells, Natural - drug effects Lysophosphatidylcholines - metabolism Lysophosphatidylcholines - pharmacology Medical sciences Phosphatidylcholines - metabolism Phospholipases A - metabolism Phospholipases A2 Phosphorylation Protein Isoforms Protein Kinase C - metabolism Staurosporine - pharmacology Toxicology Viperidae - metabolism
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