Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials
Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through a...
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| Veröffentlicht in: | Journal of the American Chemical Society 2006-06, Vol.128 (25), p.8116-8117 |
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| container_end_page | 8117 |
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| container_issue | 25 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 128 |
| creator | Balas, Francisco Manzano, Miguel Horcajada, Patricia Vallet-Regí, María |
| description | Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering. |
| doi_str_mv | 10.1021/ja062286z |
| format | Article |
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The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.</description><subject>Adsorption</subject><subject>Alendronate - chemistry</subject><subject>Bone Density Conservation Agents - chemistry</subject><subject>Chemistry</subject><subject>Drug Carriers - chemistry</subject><subject>Exact sciences and technology</subject><subject>General and physical chemistry</subject><subject>Organophosphonates - chemistry</subject><subject>Porosity</subject><subject>Silicon Dioxide - chemistry</subject><subject>Solid-liquid interface</subject><subject>Surface physical chemistry</subject><subject>Surface Properties</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1v2zAMhoWiQ5N1PfQPDL50wA5eJdmW5GMTtPtAug5NgB4FWqYxpY7kSQ7Q9tdPRYLm0gNBkHz4gnwJOWf0G6OcXa6BCs6VeDkiU1ZxmleMi2MypZTyXCpRTMjHGNepLLliJ2TChFSSVmpKmrl3nXW4QTdm4Nos1WPwfY9tdo89QsTMd9nMxuGvfw0HI8bMu-wutBgSdYvRDz74bcyWtrcG8llaSv0EBgt9_EQ-dCnh2T6fktXN9Wr-I1_cff85v1rkUJZyzOtGIghJQdVM1VVRYlNjeoRj2zBVtcxgh7zGrqDQto3k0DVIVcGMMKWgxSn5spMdgv-3xTjqjY0G-x4cpuO0ULSuS1kl8OsONMHHGLDTQ7AbCM-aUf3qp37zM7Gf96LbZoPtgdwbmICLPQDRQN8FcMbGAydrVqSHEpfvOBtHfHqbQ3jUQhay0qs_S_37YVktVcH1r4MumKjXfhtcsu6dA_8DkkyZpw</recordid><startdate>20060628</startdate><enddate>20060628</enddate><creator>Balas, Francisco</creator><creator>Manzano, Miguel</creator><creator>Horcajada, Patricia</creator><creator>Vallet-Regí, María</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060628</creationdate><title>Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials</title><author>Balas, Francisco ; Manzano, Miguel ; Horcajada, Patricia ; Vallet-Regí, María</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a447t-9b7ea670a89189534eb9e5122edb185d1cefe29ef30addb72afbe0831c6c4603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adsorption</topic><topic>Alendronate - chemistry</topic><topic>Bone Density Conservation Agents - chemistry</topic><topic>Chemistry</topic><topic>Drug Carriers - chemistry</topic><topic>Exact sciences and technology</topic><topic>General and physical chemistry</topic><topic>Organophosphonates - chemistry</topic><topic>Porosity</topic><topic>Silicon Dioxide - chemistry</topic><topic>Solid-liquid interface</topic><topic>Surface physical chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balas, Francisco</creatorcontrib><creatorcontrib>Manzano, Miguel</creatorcontrib><creatorcontrib>Horcajada, Patricia</creatorcontrib><creatorcontrib>Vallet-Regí, María</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balas, Francisco</au><au>Manzano, Miguel</au><au>Horcajada, Patricia</au><au>Vallet-Regí, María</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2006-06-28</date><risdate>2006</risdate><volume>128</volume><issue>25</issue><spage>8116</spage><epage>8117</epage><pages>8116-8117</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>Bisphosphonates have been confined in siliceous ordered mesoporous materials, and the drug release rate of these systems has been investigated. The bisphosphonate adsorption rate has been increased from 1% in oral administration to around 40% locally delivered. Drug dosage can be modulated through amine modification of the material surface, leading to a bisphosphonate adsorption in the ordered mesoporous matrices 3 times larger than that for unmodified materials. The use of these drug delivery systems opens new fields with new possibilities for tissue engineering.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>16787058</pmid><doi>10.1021/ja062286z</doi><tpages>2</tpages></addata></record> |
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| ispartof | Journal of the American Chemical Society, 2006-06, Vol.128 (25), p.8116-8117 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Adsorption Alendronate - chemistry Bone Density Conservation Agents - chemistry Chemistry Drug Carriers - chemistry Exact sciences and technology General and physical chemistry Organophosphonates - chemistry Porosity Silicon Dioxide - chemistry Solid-liquid interface Surface physical chemistry Surface Properties |
| title | Confinement and Controlled Release of Bisphosphonates on Ordered Mesoporous Silica-Based Materials |
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