Crystal growth formation in melt extrudates

The purpose of the study was to investigate the physical state of hot-melt extruded guaifenesin tablets containing either Acryl-EZE ® or Eudragit L100-55 ® and to study the physicochemical factors influencing crystal growth of guaifenesin on the surface of the extrudates. The powder mixtures contain...

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Veröffentlicht in:	International journal of pharmaceutics 2007-08, Vol.341 (1), p.162-172
Hauptverfasser:	Bruce, Caroline, Fegely, Kurt A., Rajabi-Siahboomi, Ali R., McGinity, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acryl-EZE Acrylic Resins - chemistry Biological and medical sciences Calorimetry, Differential Scanning Chemistry, Pharmaceutical Citrates - chemistry Crystallization Crystallography, X-Ray Drug Carriers Drug Compounding Drug Stability Drug Storage Eudragit ® L100-55 Excipients - chemistry General pharmacology Guaifenesin Guaifenesin - chemistry Hot-melt extrusion Humidity Hydrogen-Ion Concentration Kinetics Matrix tablets Medical sciences Microscopy, Electron, Scanning Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physical stability Plasticizers - chemistry Polymers - chemistry Powder Diffraction Recrystallization Solubility Surface Properties Tablets, Enteric-Coated Talc - chemistry Technology, Pharmaceutical - methods Transition Temperature Water - chemistry
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