Increased Level and Longevity of Protective Immune Responses Induced by DNA Vaccine Expressing the HIV-1 Env Glycoprotein when Combined with IL-21 and IL-15 Gene Delivery

We investigated the ability of a plasmid-derived IL-21 delivered alone or in combination with the IL-15 gene to regulate immune responses to the HIV-1 envelope (Env) glycoprotein induced by DNA vaccination. Mice were injected with the gp140DeltaCFI(HXB2/89.6) vector expressing a modified Env glycopr...

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Veröffentlicht in:	Journal of Immunology 2006-07, Vol.177 (1), p.177-191
Hauptverfasser:	Bolesta, Elizabeth, Kowalczyk, Aleksandra, Wierzbicki, Andrzej, Eppolito, Cheryl, Kaneko, Yutaro, Takiguchi, Masafumi, Stamatatos, Leonidas, Shrikant, Protul A, Kozbor, Danuta
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - genetics AIDS Vaccines - administration & dosage AIDS Vaccines - genetics AIDS Vaccines - immunology Animals Antibody-Dependent Cell Cytotoxicity - genetics CD8-Positive T-Lymphocytes - immunology Combined Modality Therapy env Gene Products, Human Immunodeficiency Virus Female Gene Products, env - administration & dosage Gene Products, env - biosynthesis Gene Products, env - genetics Gene Transfer Techniques HIV Antibodies - biosynthesis HIV Antibodies - physiology HIV-1 - genetics HIV-1 - immunology Human immunodeficiency virus 1 Immunization, Secondary Interleukin-15 - administration & dosage Interleukin-15 - genetics Interleukins - administration & dosage Interleukins - genetics Interleukins - physiology Mice Mice, Inbred BALB C Mice, Transgenic Neutralization Tests Rabbits Vaccines, DNA - administration & dosage Vaccines, DNA - genetics Vaccines, DNA - immunology Vaccinia virus Vaccinia virus - genetics Vaccinia virus - immunology
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