Modulation of the PI 3-kinase-Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells

Neural stem cells depend on insulin-like growth factor I (IGF-I) for differentiation. We analysed how activation and inhibition of the PI 3-kinase-Akt signalling affects the number and differentiation of mouse olfactory bulb stem cells (OBSCs). Stimulation of the pathway with insulin and/or IGF-I, l...

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Veröffentlicht in:	Journal of cell science 2006-07, Vol.119 (13), p.2739-2748
Hauptverfasser:	Otaegi, Gaizka, Yusta-Boyo, María J, Vergaño-Vera, Eva, Méndez-Gómez, Héctor R, Carrera, Ana C, Abad, José L, González, Manuel, de la Rosa, Enrique J, Vicario-Abejón, Carlos, de Pablo, Flora
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - physiology Cell Differentiation Cell Proliferation - drug effects Cells, Cultured Chromones - pharmacology Embryo, Mammalian Embryonic Induction In Vitro Techniques Insulin-Like Growth Factor I - physiology Mice Mice, Knockout Morpholines - pharmacology Mutant Proteins - metabolism Neurons - physiology Oncogene Protein v-akt - metabolism Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism PTEN Phosphohydrolase - physiology Signal Transduction Stem Cells - physiology
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