Temperature- and length-dependent energetics of formation for polyalanine helices in water: assignment of w(Ala)(n,T) and temperature-dependent CD ellipticity standards

Length-dependent helical propensities w(Ala)(n,T) at T = 10, 25, and 60 degrees C are assigned from t/c values and NMR 13C chemical shifts for series 1 peptides TrpLys(m)Inp2(t)Leu-Ala(n)(t)LeuInp2Lys(m)NH2, n = 15, 19, and 25, m = 5, in water. Van't Hoff analysis of w(Ala)(n,T) show that alpha...

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Veröffentlicht in:	Journal of the American Chemical Society 2006-06, Vol.128 (25), p.8227-8233
Hauptverfasser:	Job, Gabriel E, Kennedy, Robert J, Heitmann, Björn, Miller, Justin S, Walker, Sharon M, Kemp, Daniel S
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Computer Simulation Magnetic Resonance Spectroscopy Models, Chemical Molecular Structure Peptides - chemical synthesis Peptides - chemistry Protein Structure, Secondary Temperature Thermodynamics Water - chemistry
Online-Zugang:	Volltext
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