Primitive neuroectodermal tumor of the uterus
Abstract Background. Primitive peripheral neuroectodermal tumors (PNETs) of the uterus are rare. Recent data have demonstrated improved response rates with adjuvant chemotherapy. Case. A 26-year-old, gravida 2, para 1, Filipina female underwent an emergent cesarean section for fetal indications. Int...
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| Veröffentlicht in: | Gynecologic oncology 2007-08, Vol.106 (2), p.419-422 |
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| creator | Blattner, Jennifer Milspaw Gable, Preston Quigley, Michael M McHale, Michael T |
| description | Abstract Background. Primitive peripheral neuroectodermal tumors (PNETs) of the uterus are rare. Recent data have demonstrated improved response rates with adjuvant chemotherapy. Case. A 26-year-old, gravida 2, para 1, Filipina female underwent an emergent cesarean section for fetal indications. Intraoperative findings were remarkable for a soft tissue mass in the lower uterine segment. Histologic features, immunohistochemical findings, and chromosomal analysis were consistent with a PNET. The patient underwent radical surgery, adjuvant chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VAC/IE), and whole pelvic radiation therapy. Conclusion. Only 14 case reports of primitive neuroectodermal tumors of the uterus have been published in the English literature to date. No definitive conclusions concerning the therapeutic management and prognosis have been ascertained. |
| doi_str_mv | 10.1016/j.ygyno.2007.04.008 |
| format | Article |
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Primitive peripheral neuroectodermal tumors (PNETs) of the uterus are rare. Recent data have demonstrated improved response rates with adjuvant chemotherapy. Case. A 26-year-old, gravida 2, para 1, Filipina female underwent an emergent cesarean section for fetal indications. Intraoperative findings were remarkable for a soft tissue mass in the lower uterine segment. Histologic features, immunohistochemical findings, and chromosomal analysis were consistent with a PNET. The patient underwent radical surgery, adjuvant chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VAC/IE), and whole pelvic radiation therapy. Conclusion. Only 14 case reports of primitive neuroectodermal tumors of the uterus have been published in the English literature to date. No definitive conclusions concerning the therapeutic management and prognosis have been ascertained.</description><identifier>ISSN: 0090-8258</identifier><identifier>EISSN: 1095-6859</identifier><identifier>DOI: 10.1016/j.ygyno.2007.04.008</identifier><identifier>PMID: 17537492</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Female ; Hematology, Oncology and Palliative Medicine ; Humans ; Neuroectodermal ; Neuroectodermal Tumors, Primitive, Peripheral - diagnosis ; Neuroectodermal Tumors, Primitive, Peripheral - therapy ; Obstetrics and Gynecology ; PNET ; Pregnancy ; Pregnancy Complications, Neoplastic - diagnosis ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - therapy ; Uterus</subject><ispartof>Gynecologic oncology, 2007-08, Vol.106 (2), p.419-422</ispartof><rights>2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-f4ddaa851872c8865b2f7a67aa8d8a1c7c76c685a4f98fc6814a4964d4982c13</citedby><cites>FETCH-LOGICAL-c412t-f4ddaa851872c8865b2f7a67aa8d8a1c7c76c685a4f98fc6814a4964d4982c13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ygyno.2007.04.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17537492$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blattner, Jennifer Milspaw</creatorcontrib><creatorcontrib>Gable, Preston</creatorcontrib><creatorcontrib>Quigley, Michael M</creatorcontrib><creatorcontrib>McHale, Michael T</creatorcontrib><title>Primitive neuroectodermal tumor of the uterus</title><title>Gynecologic oncology</title><addtitle>Gynecol Oncol</addtitle><description>Abstract Background. Primitive peripheral neuroectodermal tumors (PNETs) of the uterus are rare. Recent data have demonstrated improved response rates with adjuvant chemotherapy. Case. A 26-year-old, gravida 2, para 1, Filipina female underwent an emergent cesarean section for fetal indications. Intraoperative findings were remarkable for a soft tissue mass in the lower uterine segment. Histologic features, immunohistochemical findings, and chromosomal analysis were consistent with a PNET. The patient underwent radical surgery, adjuvant chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VAC/IE), and whole pelvic radiation therapy. Conclusion. Only 14 case reports of primitive neuroectodermal tumors of the uterus have been published in the English literature to date. No definitive conclusions concerning the therapeutic management and prognosis have been ascertained.</description><subject>Adult</subject><subject>Female</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Neuroectodermal</subject><subject>Neuroectodermal Tumors, Primitive, Peripheral - diagnosis</subject><subject>Neuroectodermal Tumors, Primitive, Peripheral - therapy</subject><subject>Obstetrics and Gynecology</subject><subject>PNET</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Neoplastic - diagnosis</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - therapy</subject><subject>Uterus</subject><issn>0090-8258</issn><issn>1095-6859</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LxDAQhoMoun78AkF68tY6SdMmPSjI4hcsKOg9xHSqWdtGk3ah_96suyB48TQhPO8k8wwhpxQyCrS8WGbT29S7jAGIDHgGIHfIjEJVpKUsql0yA6gglayQB-QwhCUA5EDZPjmgosgFr9iMpE_ednawK0x6HL1DM7gafafbZBg75xPXJMM7JuOAfgzHZK_RbcCTbT0iL7c3L_P7dPF49zC_XqSGUzakDa9rrWVBpWBGyrJ4ZY3QpYh3tdTUCCNKE_-oeVPJJp4o17wqec0ryQzNj8j5pu2nd18jhkF1NhhsW92jG4MqJUQw5xHMN6DxLgSPjfqM42g_KQpqLUkt1Y8ktZakgKsoKabOtu3H1w7r38zWSgQuNwDGGVcWvQrGYm-wtj4KUrWz_zxw9SdvWttbo9sPnDAs3ej7qE9RFZgC9bze03pNIABiYfk3SlCN3g</recordid><startdate>20070801</startdate><enddate>20070801</enddate><creator>Blattner, Jennifer Milspaw</creator><creator>Gable, Preston</creator><creator>Quigley, Michael M</creator><creator>McHale, Michael T</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070801</creationdate><title>Primitive neuroectodermal tumor of the uterus</title><author>Blattner, Jennifer Milspaw ; Gable, Preston ; Quigley, Michael M ; McHale, Michael T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-f4ddaa851872c8865b2f7a67aa8d8a1c7c76c685a4f98fc6814a4964d4982c13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Female</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Neuroectodermal</topic><topic>Neuroectodermal Tumors, Primitive, Peripheral - diagnosis</topic><topic>Neuroectodermal Tumors, Primitive, Peripheral - therapy</topic><topic>Obstetrics and Gynecology</topic><topic>PNET</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Neoplastic - diagnosis</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - therapy</topic><topic>Uterus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blattner, Jennifer Milspaw</creatorcontrib><creatorcontrib>Gable, Preston</creatorcontrib><creatorcontrib>Quigley, Michael M</creatorcontrib><creatorcontrib>McHale, Michael T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gynecologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blattner, Jennifer Milspaw</au><au>Gable, Preston</au><au>Quigley, Michael M</au><au>McHale, Michael T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primitive neuroectodermal tumor of the uterus</atitle><jtitle>Gynecologic oncology</jtitle><addtitle>Gynecol Oncol</addtitle><date>2007-08-01</date><risdate>2007</risdate><volume>106</volume><issue>2</issue><spage>419</spage><epage>422</epage><pages>419-422</pages><issn>0090-8258</issn><eissn>1095-6859</eissn><abstract>Abstract Background. Primitive peripheral neuroectodermal tumors (PNETs) of the uterus are rare. Recent data have demonstrated improved response rates with adjuvant chemotherapy. Case. A 26-year-old, gravida 2, para 1, Filipina female underwent an emergent cesarean section for fetal indications. Intraoperative findings were remarkable for a soft tissue mass in the lower uterine segment. Histologic features, immunohistochemical findings, and chromosomal analysis were consistent with a PNET. The patient underwent radical surgery, adjuvant chemotherapy with vincristine, doxorubicin, cyclophosphamide, ifosfamide and etoposide (VAC/IE), and whole pelvic radiation therapy. Conclusion. Only 14 case reports of primitive neuroectodermal tumors of the uterus have been published in the English literature to date. No definitive conclusions concerning the therapeutic management and prognosis have been ascertained.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17537492</pmid><doi>10.1016/j.ygyno.2007.04.008</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Female Hematology, Oncology and Palliative Medicine Humans Neuroectodermal Neuroectodermal Tumors, Primitive, Peripheral - diagnosis Neuroectodermal Tumors, Primitive, Peripheral - therapy Obstetrics and Gynecology PNET Pregnancy Pregnancy Complications, Neoplastic - diagnosis Uterine Neoplasms - diagnosis Uterine Neoplasms - therapy Uterus |
| title | Primitive neuroectodermal tumor of the uterus |
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