Re‐expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia

Loss of Sonic Hedgehog (Shh) and aberrant CDX2 expression are early changes correlating with the presence of intestinal metaplasia that occur in the gastric mucosa prior to neoplastic transformation. The aim of this study was to compare the improvement in corpus gastritis with Shh and CDX2 expressio...

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Veröffentlicht in:	International journal of cancer 2007-09, Vol.121 (6), p.1182-1189
Hauptverfasser:	Shiotani, Akiko, Uedo, Noriya, Iishi, Hiroyasu, Tatsuta, Masaharu, Ishiguro, Shingo, Nakae, Yukinori, Kamada, Tomoari, Haruma, Ken, Merchant, Juanita L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - metabolism Adenocarcinoma - microbiology Adenocarcinoma - pathology Aged Amoxicillin - administration & dosage Anti-Bacterial Agents - administration & dosage Anti-Ulcer Agents - administration & dosage Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Biomarkers, Tumor - blood Case-Control Studies CDX2 CDX2 Transcription Factor Clarithromycin - administration & dosage Drug Therapy, Combination eradication Female gastric cancer Gastritis - metabolism Gastritis - microbiology Gastritis - pathology H. pylori Hedgehog Proteins - biosynthesis Hedgehog Proteins - drug effects Helicobacter Infections - drug therapy Helicobacter Infections - metabolism Helicobacter Infections - pathology Helicobacter pylori Homeodomain Proteins - biosynthesis Homeodomain Proteins - drug effects Human bacterial diseases Humans Immunohistochemistry incomplete intestinal metaplasia Infectious diseases Intestinal Mucosa - metabolism Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Male Medical sciences Metaplasia Middle Aged Pepsinogen A - blood Precancerous Conditions - metabolism Precancerous Conditions - microbiology Precancerous Conditions - pathology Shh Stomach Neoplasms - metabolism Stomach Neoplasms - microbiology Stomach Neoplasms - pathology Tumors
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