Detailed Analysis of Intrahepatic CD8 T Cells in the Normal and Hepatitis C-Infected Liver Reveals Differences in Specific Populations of Memory Cells with Distinct Homing Phenotypes

In hepatitis C virus (HCV) infection the immune response is ineffective, leading to chronic hepatitis and liver damage. Primed CD8 T cells are critical for antiviral immunity and subsets of circulating CD8 T cells have been defined in blood but these do not necessarily reflect the clonality or diffe...

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Veröffentlicht in:	Journal of Immunology 2006-07, Vol.177 (1), p.729-738
Hauptverfasser:	Heydtmann, Mathis, Hardie, Debbie, Shields, Philip L, Faint, Jeff, Buckley, Christopher D, Campbell, James J, Salmon, Michael, Adams, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	CD11a Antigen - biosynthesis CD11a Antigen - blood CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Movement - immunology Chemokine CCL19 Chemokines, CC - blood Chemokines, CC - metabolism Child Hepacivirus - immunology Hepatitis C virus Hepatitis C, Chronic - immunology Hepatitis C, Chronic - metabolism Hepatitis C, Chronic - pathology Hepatocytes - cytology Hepatocytes - immunology Hepatocytes - pathology Humans Immunologic Memory - immunology Immunophenotyping Leukocyte Common Antigens - biosynthesis Leukocyte Common Antigens - blood Ligands Liver Cirrhosis - immunology Liver Cirrhosis - metabolism Lymphocyte Function-Associated Antigen-1 - biosynthesis Lymphocyte Function-Associated Antigen-1 - blood Receptors, CCR7 Receptors, Chemokine - blood Receptors, Chemokine - metabolism Receptors, CXCR4 - biosynthesis Receptors, CXCR4 - blood Receptors, CXCR4 - metabolism Receptors, Lymphocyte Homing - biosynthesis Receptors, Lymphocyte Homing - blood T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocyte Subsets - pathology Tumor Necrosis Factor Receptor Superfamily, Member 7 - biosynthesis Tumor Necrosis Factor Receptor Superfamily, Member 7 - blood
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