The significance of glucocorticoid pulsatility
Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level...
Gespeichert in:
| Veröffentlicht in: | European journal of pharmacology 2008-04, Vol.583 (2), p.255-262 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 262 |
|---|---|
| container_issue | 2 |
| container_start_page | 255 |
| container_title | European journal of pharmacology |
| container_volume | 583 |
| creator | Lightman, Stafford L. Wiles, Crispin C. Atkinson, Helen C. Henley, David E. Russell, Georgina M. Leendertz, Jack A. McKenna, Mervyn A. Spiga, Francesca Wood, Susan A. Conway-Campbell, Becky L. |
| description | Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors — the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor. |
| doi_str_mv | 10.1016/j.ejphar.2007.11.073 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68097299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0014299908000289</els_id><sourcerecordid>68097299</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-ecc93f855a35df7cd2864b7e52f41a8e1f25ea335656263d677b1c0b053079223</originalsourceid><addsrcrecordid>eNp9kM9LwzAYhoMobk7_A5GdvLXmS5qmuQgy_AUDL_Mc0vTrltItNWkF_3s7OvDm6bs87_vxPoTcAk2BQv7QpNh0OxNSRqlMAVIq-RmZQyFVQiWwczKnFLKEKaVm5CrGhlIqFBOXZAYF54pLPifpZofL6LYHVztrDhaXvl5u28F660PvrHfVshvaaHrXuv7nmlzUpo14c7oL8vnyvFm9JeuP1_fV0zqxmYA-QWsVrwshDBdVLW3FijwrJQpWZ2AKhJoJNJyLXOQs51UuZQmWllRwKhVjfEHup94u-K8BY6_3LlpsW3NAP0SdF1TJcdkIZhNog48xYK274PYm_Gig-uhJN3rypI-eNIAePY2xu1P_UO6x-gudxIzA4wTguPLbYdDROhz9VC6g7XXl3f8ffgGhK3op</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68097299</pqid></control><display><type>article</type><title>The significance of glucocorticoid pulsatility</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Lightman, Stafford L. ; Wiles, Crispin C. ; Atkinson, Helen C. ; Henley, David E. ; Russell, Georgina M. ; Leendertz, Jack A. ; McKenna, Mervyn A. ; Spiga, Francesca ; Wood, Susan A. ; Conway-Campbell, Becky L.</creator><creatorcontrib>Lightman, Stafford L. ; Wiles, Crispin C. ; Atkinson, Helen C. ; Henley, David E. ; Russell, Georgina M. ; Leendertz, Jack A. ; McKenna, Mervyn A. ; Spiga, Francesca ; Wood, Susan A. ; Conway-Campbell, Becky L.</creatorcontrib><description>Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors — the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/j.ejphar.2007.11.073</identifier><identifier>PMID: 18339373</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Activity Cycles - physiology ; Animals ; Glucocorticoid receptor ; Glucocorticoids - metabolism ; Humans ; Hypothalamo-Hypophyseal System - metabolism ; Mineralocorticoid receptor ; Pituitary-Adrenal System - metabolism ; Proteasome ; Rats ; Signal Transduction - physiology ; Stress, Physiological - metabolism ; Time Factors ; Ultradian rhythm</subject><ispartof>European journal of pharmacology, 2008-04, Vol.583 (2), p.255-262</ispartof><rights>2008 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-ecc93f855a35df7cd2864b7e52f41a8e1f25ea335656263d677b1c0b053079223</citedby><cites>FETCH-LOGICAL-c451t-ecc93f855a35df7cd2864b7e52f41a8e1f25ea335656263d677b1c0b053079223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0014299908000289$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18339373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lightman, Stafford L.</creatorcontrib><creatorcontrib>Wiles, Crispin C.</creatorcontrib><creatorcontrib>Atkinson, Helen C.</creatorcontrib><creatorcontrib>Henley, David E.</creatorcontrib><creatorcontrib>Russell, Georgina M.</creatorcontrib><creatorcontrib>Leendertz, Jack A.</creatorcontrib><creatorcontrib>McKenna, Mervyn A.</creatorcontrib><creatorcontrib>Spiga, Francesca</creatorcontrib><creatorcontrib>Wood, Susan A.</creatorcontrib><creatorcontrib>Conway-Campbell, Becky L.</creatorcontrib><title>The significance of glucocorticoid pulsatility</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors — the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor.</description><subject>Activity Cycles - physiology</subject><subject>Animals</subject><subject>Glucocorticoid receptor</subject><subject>Glucocorticoids - metabolism</subject><subject>Humans</subject><subject>Hypothalamo-Hypophyseal System - metabolism</subject><subject>Mineralocorticoid receptor</subject><subject>Pituitary-Adrenal System - metabolism</subject><subject>Proteasome</subject><subject>Rats</subject><subject>Signal Transduction - physiology</subject><subject>Stress, Physiological - metabolism</subject><subject>Time Factors</subject><subject>Ultradian rhythm</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9LwzAYhoMobk7_A5GdvLXmS5qmuQgy_AUDL_Mc0vTrltItNWkF_3s7OvDm6bs87_vxPoTcAk2BQv7QpNh0OxNSRqlMAVIq-RmZQyFVQiWwczKnFLKEKaVm5CrGhlIqFBOXZAYF54pLPifpZofL6LYHVztrDhaXvl5u28F660PvrHfVshvaaHrXuv7nmlzUpo14c7oL8vnyvFm9JeuP1_fV0zqxmYA-QWsVrwshDBdVLW3FijwrJQpWZ2AKhJoJNJyLXOQs51UuZQmWllRwKhVjfEHup94u-K8BY6_3LlpsW3NAP0SdF1TJcdkIZhNog48xYK274PYm_Gig-uhJN3rypI-eNIAePY2xu1P_UO6x-gudxIzA4wTguPLbYdDROhz9VC6g7XXl3f8ffgGhK3op</recordid><startdate>20080407</startdate><enddate>20080407</enddate><creator>Lightman, Stafford L.</creator><creator>Wiles, Crispin C.</creator><creator>Atkinson, Helen C.</creator><creator>Henley, David E.</creator><creator>Russell, Georgina M.</creator><creator>Leendertz, Jack A.</creator><creator>McKenna, Mervyn A.</creator><creator>Spiga, Francesca</creator><creator>Wood, Susan A.</creator><creator>Conway-Campbell, Becky L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080407</creationdate><title>The significance of glucocorticoid pulsatility</title><author>Lightman, Stafford L. ; Wiles, Crispin C. ; Atkinson, Helen C. ; Henley, David E. ; Russell, Georgina M. ; Leendertz, Jack A. ; McKenna, Mervyn A. ; Spiga, Francesca ; Wood, Susan A. ; Conway-Campbell, Becky L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-ecc93f855a35df7cd2864b7e52f41a8e1f25ea335656263d677b1c0b053079223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Activity Cycles - physiology</topic><topic>Animals</topic><topic>Glucocorticoid receptor</topic><topic>Glucocorticoids - metabolism</topic><topic>Humans</topic><topic>Hypothalamo-Hypophyseal System - metabolism</topic><topic>Mineralocorticoid receptor</topic><topic>Pituitary-Adrenal System - metabolism</topic><topic>Proteasome</topic><topic>Rats</topic><topic>Signal Transduction - physiology</topic><topic>Stress, Physiological - metabolism</topic><topic>Time Factors</topic><topic>Ultradian rhythm</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lightman, Stafford L.</creatorcontrib><creatorcontrib>Wiles, Crispin C.</creatorcontrib><creatorcontrib>Atkinson, Helen C.</creatorcontrib><creatorcontrib>Henley, David E.</creatorcontrib><creatorcontrib>Russell, Georgina M.</creatorcontrib><creatorcontrib>Leendertz, Jack A.</creatorcontrib><creatorcontrib>McKenna, Mervyn A.</creatorcontrib><creatorcontrib>Spiga, Francesca</creatorcontrib><creatorcontrib>Wood, Susan A.</creatorcontrib><creatorcontrib>Conway-Campbell, Becky L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lightman, Stafford L.</au><au>Wiles, Crispin C.</au><au>Atkinson, Helen C.</au><au>Henley, David E.</au><au>Russell, Georgina M.</au><au>Leendertz, Jack A.</au><au>McKenna, Mervyn A.</au><au>Spiga, Francesca</au><au>Wood, Susan A.</au><au>Conway-Campbell, Becky L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The significance of glucocorticoid pulsatility</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2008-04-07</date><risdate>2008</risdate><volume>583</volume><issue>2</issue><spage>255</spage><epage>262</epage><pages>255-262</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species that have been studied. In the rat there is an approximately hourly rhythm of corticosterone secretion, which appears to be regulated by alternating activation and inhibition of the HPA axis. At the level of signal transduction, the response to these pulses of corticosterone is determined by its dynamic interaction with the two transcription factors — the glucocorticoid and mineralocorticoid receptors. While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone. This phasic response is regulated by an intranuclear proteasome-dependent rapid downregulation of the activated glucocorticoid receptor.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>18339373</pmid><doi>10.1016/j.ejphar.2007.11.073</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2999 |
| ispartof | European journal of pharmacology, 2008-04, Vol.583 (2), p.255-262 |
| issn | 0014-2999 1879-0712 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68097299 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Activity Cycles - physiology Animals Glucocorticoid receptor Glucocorticoids - metabolism Humans Hypothalamo-Hypophyseal System - metabolism Mineralocorticoid receptor Pituitary-Adrenal System - metabolism Proteasome Rats Signal Transduction - physiology Stress, Physiological - metabolism Time Factors Ultradian rhythm |
| title | The significance of glucocorticoid pulsatility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T13%3A06%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20significance%20of%20glucocorticoid%20pulsatility&rft.jtitle=European%20journal%20of%20pharmacology&rft.au=Lightman,%20Stafford%20L.&rft.date=2008-04-07&rft.volume=583&rft.issue=2&rft.spage=255&rft.epage=262&rft.pages=255-262&rft.issn=0014-2999&rft.eissn=1879-0712&rft_id=info:doi/10.1016/j.ejphar.2007.11.073&rft_dat=%3Cproquest_cross%3E68097299%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68097299&rft_id=info:pmid/18339373&rft_els_id=S0014299908000289&rfr_iscdi=true |