O-Glycosylation Regulates Autolysis of Cellular Membrane Type-1 Matrix Metalloproteinase (MT1-MMP)

MT1-MMP is a key enzyme in cancer cell invasion and metastasis. The activity of cellular MT1-MMP is regulated by furin-like proprotein convertases, TIMPs, shedding, autoproteolysis, dimerization, exocytosis, endocytosis, and recycling. Our data demonstrate that, in addition to these already known me...

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Veröffentlicht in:	The Journal of biological chemistry 2006-06, Vol.281 (25), p.16897-16905
Hauptverfasser:	Remacle, Albert G., Chekanov, Alexei V., Golubkov, Vladislav S., Savinov, Alexei Y., Rozanov, Dmitri V., Strongin, Alex Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Catalytic Domain Cell Line, Tumor Cell Membrane - metabolism CHO Cells Cricetinae Female Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glycosylation Humans Matrix Metalloproteinase 14 Matrix Metalloproteinases - chemistry Matrix Metalloproteinases - metabolism Matrix Metalloproteinases, Membrane-Associated Mice Mice, Inbred BALB C Models, Genetic Neoplasm Transplantation
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