Efficacy of Combined Modality Prophylaxis Including Short-Duration Warfarin to Prevent Venous Thromboembolism After Total Hip Arthroplasty
This study reviewed the effectiveness of a trimodality deep venous thrombosis (DVT) prophylactic regimen after primary and revision total hip arthroplasty. Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower ex...
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| Veröffentlicht in: | The Journal of arthroplasty 2006-06, Vol.21 (4), p.469-475 |
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| creator | Keeney, James A. Clohisy, John C. Curry, Madelyn C. Maloney, William J. |
| description | This study reviewed the effectiveness of a trimodality deep venous thrombosis (DVT) prophylactic regimen after primary and revision total hip arthroplasty. Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower extremity venous ultrasonography was obtained on postoperative day 3 or 4. The incidence of asymptomatic DVT, symptomatic DVT/pulmonary embolus events within 90 days of surgery, and potential influence of risk factors was retrospectively assessed. Deep venous thrombosis incidence was 4.4% with one (0.1%) nonfatal pulmonary embolus. Increased age, male sex, and DVT history were significant risk factors for thromboembolic events within 90 days of hip arthroplasty. The combination of short-duration warfarin and mechanical prophylaxis with predischarge ultrasound screening was safe and effective in limiting the occurrence of venous thromboembolism. |
| doi_str_mv | 10.1016/j.arth.2005.06.017 |
| format | Article |
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Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower extremity venous ultrasonography was obtained on postoperative day 3 or 4. The incidence of asymptomatic DVT, symptomatic DVT/pulmonary embolus events within 90 days of surgery, and potential influence of risk factors was retrospectively assessed. Deep venous thrombosis incidence was 4.4% with one (0.1%) nonfatal pulmonary embolus. Increased age, male sex, and DVT history were significant risk factors for thromboembolic events within 90 days of hip arthroplasty. 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Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower extremity venous ultrasonography was obtained on postoperative day 3 or 4. The incidence of asymptomatic DVT, symptomatic DVT/pulmonary embolus events within 90 days of surgery, and potential influence of risk factors was retrospectively assessed. Deep venous thrombosis incidence was 4.4% with one (0.1%) nonfatal pulmonary embolus. Increased age, male sex, and DVT history were significant risk factors for thromboembolic events within 90 days of hip arthroplasty. The combination of short-duration warfarin and mechanical prophylaxis with predischarge ultrasound screening was safe and effective in limiting the occurrence of venous thromboembolism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants - therapeutic use</subject><subject>anticoagulation</subject><subject>Arthroplasty, Replacement, Hip - adverse effects</subject><subject>Bandages</subject><subject>Combined Modality Therapy</subject><subject>Coumadin</subject><subject>deep vein thromboembolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Postoperative Complications - prevention & control</subject><subject>pulmonary embolism</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Thromboembolism - prevention & control</subject><subject>total hip arthroplasty</subject><subject>Treatment Outcome</subject><subject>Venous Thrombosis - prevention & control</subject><subject>Walking</subject><subject>Warfarin - therapeutic use</subject><issn>0883-5403</issn><issn>1532-8406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuO0zAUhi0EYsrAC7BAXrFL8C2JLbGpOgMz0iCQKLC0XF-oKycutjMir8BT46qV2LE4Opvv_8_lB-A1Ri1GuH93aFUq-5Yg1LWobxEenoAV7ihpOEP9U7BCnNOmY4hegRc5HxDCuOvYc3CF-4FjKvoV-HPrnNdKLzA6uInjzk_WwE_RqODLAr-keNwvQf32Gd5POszGTz_h131MpbmZkyo-TvCHSk4lP8ESq8A-2qnA73aKc4bbfaqe0dYKPo9w7YpNcBuLCvDOH-G6HlBHBJXL8hI8cypk--rSr8G3D7fbzV3z8Pnj_Wb90Gg6iNIIgbGiTvVWaNYhTnpDBsaRInhHiMDaMc04U4JqYwbKMSNO05123AnSCUevwduz7zHFX7PNRY4-axuCmmzdWfYciU5gUUFyBnWKOSfr5DH5UaVFYiRPCciDPCUgTwlI1MuaQBW9ubjPu9Gaf5LLyyvw_gzYeuOjt0lm7e2krfHJ6iJN9P_z_wtpmpot</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Keeney, James A.</creator><creator>Clohisy, John C.</creator><creator>Curry, Madelyn C.</creator><creator>Maloney, William J.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060601</creationdate><title>Efficacy of Combined Modality Prophylaxis Including Short-Duration Warfarin to Prevent Venous Thromboembolism After Total Hip Arthroplasty</title><author>Keeney, James A. ; Clohisy, John C. ; Curry, Madelyn C. ; Maloney, William J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-9911a3fa6e9c450826d27480a21b2291cf4c484a93cdd738142fc3bcf8f9259f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants - therapeutic use</topic><topic>anticoagulation</topic><topic>Arthroplasty, Replacement, Hip - adverse effects</topic><topic>Bandages</topic><topic>Combined Modality Therapy</topic><topic>Coumadin</topic><topic>deep vein thromboembolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Postoperative Complications - prevention & control</topic><topic>pulmonary embolism</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Thromboembolism - prevention & control</topic><topic>total hip arthroplasty</topic><topic>Treatment Outcome</topic><topic>Venous Thrombosis - prevention & control</topic><topic>Walking</topic><topic>Warfarin - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keeney, James A.</creatorcontrib><creatorcontrib>Clohisy, John C.</creatorcontrib><creatorcontrib>Curry, Madelyn C.</creatorcontrib><creatorcontrib>Maloney, William J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of arthroplasty</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keeney, James A.</au><au>Clohisy, John C.</au><au>Curry, Madelyn C.</au><au>Maloney, William J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of Combined Modality Prophylaxis Including Short-Duration Warfarin to Prevent Venous Thromboembolism After Total Hip Arthroplasty</atitle><jtitle>The Journal of arthroplasty</jtitle><addtitle>J Arthroplasty</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>21</volume><issue>4</issue><spage>469</spage><epage>475</epage><pages>469-475</pages><issn>0883-5403</issn><eissn>1532-8406</eissn><abstract>This study reviewed the effectiveness of a trimodality deep venous thrombosis (DVT) prophylactic regimen after primary and revision total hip arthroplasty. Seven hundred five patients were treated with pneumatic compression, adjusted dose warfarin (7 days), and early mobilization. Bilateral lower extremity venous ultrasonography was obtained on postoperative day 3 or 4. The incidence of asymptomatic DVT, symptomatic DVT/pulmonary embolus events within 90 days of surgery, and potential influence of risk factors was retrospectively assessed. Deep venous thrombosis incidence was 4.4% with one (0.1%) nonfatal pulmonary embolus. Increased age, male sex, and DVT history were significant risk factors for thromboembolic events within 90 days of hip arthroplasty. The combination of short-duration warfarin and mechanical prophylaxis with predischarge ultrasound screening was safe and effective in limiting the occurrence of venous thromboembolism.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16781396</pmid><doi>10.1016/j.arth.2005.06.017</doi><tpages>7</tpages></addata></record> |
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| ispartof | The Journal of arthroplasty, 2006-06, Vol.21 (4), p.469-475 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adolescent Adult Aged Aged, 80 and over Anticoagulants - therapeutic use anticoagulation Arthroplasty, Replacement, Hip - adverse effects Bandages Combined Modality Therapy Coumadin deep vein thromboembolism Female Humans Male Middle Aged Motor Activity Postoperative Complications - prevention & control pulmonary embolism Regression Analysis Retrospective Studies Thromboembolism - prevention & control total hip arthroplasty Treatment Outcome Venous Thrombosis - prevention & control Walking Warfarin - therapeutic use |
| title | Efficacy of Combined Modality Prophylaxis Including Short-Duration Warfarin to Prevent Venous Thromboembolism After Total Hip Arthroplasty |
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