N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission
N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission Michael Weber, Oscar Bazzino, Jose L. Navarro Estrada, Juan J. Fuselli, Fernando Botto, Diego Perez de Arenaza, Helge Möl...
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| Veröffentlicht in: | Journal of the American College of Cardiology 2008-03, Vol.51 (12), p.1188-1195 |
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| creator | Weber, Michael, MD Bazzino, Oscar, MD Navarro Estrada, Jose L., MD Fuselli, Juan J., MD Botto, Fernando, MD Perez de Arenaza, Diego, MD Möllmann, Helge, MD Nef, Holger N., MD Elsässer, Albrecht, MD Hamm, Christian W., MD |
| description | N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission Michael Weber, Oscar Bazzino, Jose L. Navarro Estrada, Juan J. Fuselli, Fernando Botto, Diego Perez de Arenaza, Helge Möllmann, Holger N. Nef, Albrecht Elsässer, Christian W. Hamm We aimed to determine the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in 2,614 troponin negative (troponin T ≤0.01 ng/ml) patients from 2 different registries with evident or suspected acute coronary syndromes (ACS). In these two cohorts, receiver-operating characteristic curve analysis yielded an optimal cutoff value of 474 pg/ml for NT-proBNP that was able to discriminate patients at higher risk in the Bad Nauheim ACS and Prognosis in Acute Coronary Syndromes registries (mortality rate 12.3% vs. 1.3%, p < 0.001 and 8.5% vs. 1.5%, p < 0.001, respectively). Therefore, our study, in combination with previously published data, strongly suggests the implementation of NT-proBNP assessment for risk stratification of patients with chest pain or suspected non–ST-segment elevation ACS and negative troponin values. |
| doi_str_mv | 10.1016/j.jacc.2007.11.054 |
| format | Article |
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Navarro Estrada, Juan J. Fuselli, Fernando Botto, Diego Perez de Arenaza, Helge Möllmann, Holger N. Nef, Albrecht Elsässer, Christian W. Hamm We aimed to determine the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in 2,614 troponin negative (troponin T ≤0.01 ng/ml) patients from 2 different registries with evident or suspected acute coronary syndromes (ACS). In these two cohorts, receiver-operating characteristic curve analysis yielded an optimal cutoff value of 474 pg/ml for NT-proBNP that was able to discriminate patients at higher risk in the Bad Nauheim ACS and Prognosis in Acute Coronary Syndromes registries (mortality rate 12.3% vs. 1.3%, p < 0.001 and 8.5% vs. 1.5%, p < 0.001, respectively). Therefore, our study, in combination with previously published data, strongly suggests the implementation of NT-proBNP assessment for risk stratification of patients with chest pain or suspected non–ST-segment elevation ACS and negative troponin values.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2007.11.054</identifier><identifier>PMID: 18355657</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Acute Coronary Syndrome - blood ; Acute Coronary Syndrome - diagnosis ; Acute coronary syndromes ; Aged ; Angina pectoris ; Biological and medical sciences ; Biomarkers - blood ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cohort Studies ; Coronary heart disease ; Coronary vessels ; Electrocardiography ; Female ; Heart ; Heart attacks ; Humans ; Internal Medicine ; Male ; Medical sciences ; Middle Aged ; Myocarditis. Cardiomyopathies ; Natriuretic Peptide, Brain - blood ; Peptide Fragments - blood ; Predictive Value of Tests ; Prognosis ; Risk Assessment ; Sensitivity and Specificity ; Troponin T - blood</subject><ispartof>Journal of the American College of Cardiology, 2008-03, Vol.51 (12), p.1188-1195</ispartof><rights>American College of Cardiology Foundation</rights><rights>2008 American College of Cardiology Foundation</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Elsevier Limited Mar 25, 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-a65016244035941a8c5d79a4e0c4ab58132ce9d3e5ac9fb8781d6af3b7e2dab93</citedby><cites>FETCH-LOGICAL-c503t-a65016244035941a8c5d79a4e0c4ab58132ce9d3e5ac9fb8781d6af3b7e2dab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2007.11.054$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20218305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18355657$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Weber, Michael, MD</creatorcontrib><creatorcontrib>Bazzino, Oscar, MD</creatorcontrib><creatorcontrib>Navarro Estrada, Jose L., MD</creatorcontrib><creatorcontrib>Fuselli, Juan J., MD</creatorcontrib><creatorcontrib>Botto, Fernando, MD</creatorcontrib><creatorcontrib>Perez de Arenaza, Diego, MD</creatorcontrib><creatorcontrib>Möllmann, Helge, MD</creatorcontrib><creatorcontrib>Nef, Holger N., MD</creatorcontrib><creatorcontrib>Elsässer, Albrecht, MD</creatorcontrib><creatorcontrib>Hamm, Christian W., MD</creatorcontrib><title>N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission Michael Weber, Oscar Bazzino, Jose L. Navarro Estrada, Juan J. Fuselli, Fernando Botto, Diego Perez de Arenaza, Helge Möllmann, Holger N. Nef, Albrecht Elsässer, Christian W. Hamm We aimed to determine the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in 2,614 troponin negative (troponin T ≤0.01 ng/ml) patients from 2 different registries with evident or suspected acute coronary syndromes (ACS). In these two cohorts, receiver-operating characteristic curve analysis yielded an optimal cutoff value of 474 pg/ml for NT-proBNP that was able to discriminate patients at higher risk in the Bad Nauheim ACS and Prognosis in Acute Coronary Syndromes registries (mortality rate 12.3% vs. 1.3%, p < 0.001 and 8.5% vs. 1.5%, p < 0.001, respectively). Therefore, our study, in combination with previously published data, strongly suggests the implementation of NT-proBNP assessment for risk stratification of patients with chest pain or suspected non–ST-segment elevation ACS and negative troponin values.</description><subject>Acute Coronary Syndrome - blood</subject><subject>Acute Coronary Syndrome - diagnosis</subject><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angina pectoris</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiology</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cohort Studies</subject><subject>Coronary heart disease</subject><subject>Coronary vessels</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart</subject><subject>Heart attacks</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocarditis. Cardiomyopathies</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Peptide Fragments - blood</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Risk Assessment</subject><subject>Sensitivity and Specificity</subject><subject>Troponin T - blood</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt2O0zAQhSMEYsvCC3CBLCG4S7GTOHYktFKp-Km0KpW2C5eWa0_AJbGLnazU1-IJmagVK-0FV3HG35lMzpkse8nonFFWv9vP99qYeUGpmDM2p7x6lM0Y5zIveSMeZzMqSp4z2oiL7FlKe0ppLVnzNLtgsuS85mKW_VnnW4i987ojH_Lt8QBkrYfoxgiDM2QDh8FZIIuUIKUe_EA2MdxhKZGVNxGmEkqx-MOHNElWvg2x14MLnjhPNnhCJpHvbvhJFmYcgCxDDF7HI7k5ehtDj820t2Q96TqyjeEQPEq35JvuRry8xXeysL1LCbs-z560ukvw4vy8zG4_fdwuv-TXXz-vlovr3HBaDrmuOZpUVBVFNyqmpeFWNLoCaiq945KVhYHGlsC1adqdFJLZWrflTkBh9a4pL7O3p76HGH7jGIPCAQx0nfYQxqRqSRsumEDw9QNwH8aIjibFOK0LKkRRIlWcKBNDShFadYiuRxcUo2rKU-3VlKea8lSMKcwTRa_OrcddD_Zecg4QgTdnQCejuzZqb1z6xxW0QJRy5N6fOEDH7hxElQzmYsC6CGZQNrj_z3H1QG465x1-8RccId3_r0qFoupm2rxp8ajEpRNSln8BjC_Vxg</recordid><startdate>20080325</startdate><enddate>20080325</enddate><creator>Weber, Michael, MD</creator><creator>Bazzino, Oscar, MD</creator><creator>Navarro Estrada, Jose L., MD</creator><creator>Fuselli, Juan J., MD</creator><creator>Botto, Fernando, MD</creator><creator>Perez de Arenaza, Diego, MD</creator><creator>Möllmann, Helge, MD</creator><creator>Nef, Holger N., MD</creator><creator>Elsässer, Albrecht, MD</creator><creator>Hamm, Christian W., MD</creator><general>Elsevier Inc</general><general>Elsevier Science</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080325</creationdate><title>N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission</title><author>Weber, Michael, MD ; Bazzino, Oscar, MD ; Navarro Estrada, Jose L., MD ; Fuselli, Juan J., MD ; Botto, Fernando, MD ; Perez de Arenaza, Diego, MD ; Möllmann, Helge, MD ; Nef, Holger N., MD ; Elsässer, Albrecht, MD ; Hamm, Christian W., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-a65016244035941a8c5d79a4e0c4ab58132ce9d3e5ac9fb8781d6af3b7e2dab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Acute Coronary Syndrome - blood</topic><topic>Acute Coronary Syndrome - diagnosis</topic><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angina pectoris</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiology</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cohort Studies</topic><topic>Coronary heart disease</topic><topic>Coronary vessels</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart</topic><topic>Heart attacks</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocarditis. 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Navarro Estrada, Juan J. Fuselli, Fernando Botto, Diego Perez de Arenaza, Helge Möllmann, Holger N. Nef, Albrecht Elsässer, Christian W. Hamm We aimed to determine the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in 2,614 troponin negative (troponin T ≤0.01 ng/ml) patients from 2 different registries with evident or suspected acute coronary syndromes (ACS). In these two cohorts, receiver-operating characteristic curve analysis yielded an optimal cutoff value of 474 pg/ml for NT-proBNP that was able to discriminate patients at higher risk in the Bad Nauheim ACS and Prognosis in Acute Coronary Syndromes registries (mortality rate 12.3% vs. 1.3%, p < 0.001 and 8.5% vs. 1.5%, p < 0.001, respectively). Therefore, our study, in combination with previously published data, strongly suggests the implementation of NT-proBNP assessment for risk stratification of patients with chest pain or suspected non–ST-segment elevation ACS and negative troponin values.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>18355657</pmid><doi>10.1016/j.jacc.2007.11.054</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acute Coronary Syndrome - blood Acute Coronary Syndrome - diagnosis Acute coronary syndromes Aged Angina pectoris Biological and medical sciences Biomarkers - blood Cardiology Cardiology. Vascular system Cardiovascular Cohort Studies Coronary heart disease Coronary vessels Electrocardiography Female Heart Heart attacks Humans Internal Medicine Male Medical sciences Middle Aged Myocarditis. Cardiomyopathies Natriuretic Peptide, Brain - blood Peptide Fragments - blood Predictive Value of Tests Prognosis Risk Assessment Sensitivity and Specificity Troponin T - blood |
| title | N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission |
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