The distinctive biology of cancer in adolescents and young adults
Key Points The relative lack of progress in treating cancer in adolescents and young adults (AYAs) is in part due to a lack of appreciation of differences in the biology of malignant diseases in this age group relative to younger and older persons. Molecular, epidemiological and therapeutic outcome...
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| Veröffentlicht in: | Nature reviews. Cancer 2008-04, Vol.8 (4), p.288-298 |
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| container_title | Nature reviews. Cancer |
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| creator | Bleyer, Archie Barr, Ronald Hayes-Lattin, Brandon Thomas, David Ellis, Chad Anderson, Barry |
| description | Key Points
The relative lack of progress in treating cancer in adolescents and young adults (AYAs) is in part due to a lack of appreciation of differences in the biology of malignant diseases in this age group relative to younger and older persons.
Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of AYAs, including leukaemias, lymphomas, sarcomas, melanoma, and carcinomas of the breast, colon, rectum and nasopharynx.
Translational and clinical research should not assume that the biology of cancers and AYA hosts is the same as in other age groups, even if the diseases seem the same clinically and histopathologically.
A systematic review of previously reported biological and therapeutic outcomes, that combines older adolescent and young adult patients with younger and older persons, should be made of biological differences if the numbers of subjects or samples permit an adequate assessment.
In addition, prospective studies evaluating potential biological differences should be incorporated into investigations that include patients across the age spectrum.
Therapeutic strategies tailored to the AYA age group, based on the distinct biology of the cancer and the host, might improve outcomes and prognosis.
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different. Do molecular, epidemiological and therapeutic outcome comparisons support this?
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences. |
| doi_str_mv | 10.1038/nrc2349 |
| format | Article |
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The relative lack of progress in treating cancer in adolescents and young adults (AYAs) is in part due to a lack of appreciation of differences in the biology of malignant diseases in this age group relative to younger and older persons.
Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of AYAs, including leukaemias, lymphomas, sarcomas, melanoma, and carcinomas of the breast, colon, rectum and nasopharynx.
Translational and clinical research should not assume that the biology of cancers and AYA hosts is the same as in other age groups, even if the diseases seem the same clinically and histopathologically.
A systematic review of previously reported biological and therapeutic outcomes, that combines older adolescent and young adult patients with younger and older persons, should be made of biological differences if the numbers of subjects or samples permit an adequate assessment.
In addition, prospective studies evaluating potential biological differences should be incorporated into investigations that include patients across the age spectrum.
Therapeutic strategies tailored to the AYA age group, based on the distinct biology of the cancer and the host, might improve outcomes and prognosis.
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different. Do molecular, epidemiological and therapeutic outcome comparisons support this?
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.</description><identifier>ISSN: 1474-175X</identifier><identifier>EISSN: 1474-1768</identifier><identifier>DOI: 10.1038/nrc2349</identifier><identifier>PMID: 18354417</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adolescent ; Adult ; Biomedical and Life Sciences ; Biomedicine ; Cancer ; Cancer Research ; Care and treatment ; Health aspects ; Humans ; Medical examination ; Methods ; Neoplasms - pathology ; review-article ; Young adults</subject><ispartof>Nature reviews. Cancer, 2008-04, Vol.8 (4), p.288-298</ispartof><rights>Springer Nature Limited 2008</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Apr 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c556t-6fb1d18857533bee77ea487c1197ee5e7d885ec7bcc798a5d08ed033cdf05fb93</citedby><cites>FETCH-LOGICAL-c556t-6fb1d18857533bee77ea487c1197ee5e7d885ec7bcc798a5d08ed033cdf05fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrc2349$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrc2349$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18354417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bleyer, Archie</creatorcontrib><creatorcontrib>Barr, Ronald</creatorcontrib><creatorcontrib>Hayes-Lattin, Brandon</creatorcontrib><creatorcontrib>Thomas, David</creatorcontrib><creatorcontrib>Ellis, Chad</creatorcontrib><creatorcontrib>Anderson, Barry</creatorcontrib><creatorcontrib>Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</creatorcontrib><creatorcontrib>on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</creatorcontrib><title>The distinctive biology of cancer in adolescents and young adults</title><title>Nature reviews. Cancer</title><addtitle>Nat Rev Cancer</addtitle><addtitle>Nat Rev Cancer</addtitle><description>Key Points
The relative lack of progress in treating cancer in adolescents and young adults (AYAs) is in part due to a lack of appreciation of differences in the biology of malignant diseases in this age group relative to younger and older persons.
Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of AYAs, including leukaemias, lymphomas, sarcomas, melanoma, and carcinomas of the breast, colon, rectum and nasopharynx.
Translational and clinical research should not assume that the biology of cancers and AYA hosts is the same as in other age groups, even if the diseases seem the same clinically and histopathologically.
A systematic review of previously reported biological and therapeutic outcomes, that combines older adolescent and young adult patients with younger and older persons, should be made of biological differences if the numbers of subjects or samples permit an adequate assessment.
In addition, prospective studies evaluating potential biological differences should be incorporated into investigations that include patients across the age spectrum.
Therapeutic strategies tailored to the AYA age group, based on the distinct biology of the cancer and the host, might improve outcomes and prognosis.
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different. Do molecular, epidemiological and therapeutic outcome comparisons support this?
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer</subject><subject>Cancer Research</subject><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Medical examination</subject><subject>Methods</subject><subject>Neoplasms - pathology</subject><subject>review-article</subject><subject>Young adults</subject><issn>1474-175X</issn><issn>1474-1768</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkV1rHCEUhqU0NB8t_QUtQwNJbjbVcRydyyXkCwK9SaF34uiZXYOrqTqF_fdxmU3SpIWgoJz3Oa--HIQ-E3xKMBXffdQ1bbp3aI80vJkR3or3T3f2axftp3SHMWkJJx_QLhGUNQ3he2h-u4TK2JSt19n-gaq3wYXFugpDpZXXECvrK2WCg6TB51Qpb6p1GP2iVEeX00e0MyiX4NP2PEA_L85vz65mNz8ur8_mNzPNWJtn7dATQ4RgnFHaA3AOqhFcE9JxAAbcFA0077XmnVDMYAEGU6rNgNnQd_QAHU2-9zH8HiFlubLlS84pD2FMshW4Y6x-G6xxW2NGSQG_vQLvwhh9CSFrzkhbNi3Q4QQtlANp_RByVHrjKOeEdzXvcLN58_Q_VFkGVlYHD4Mt9RcNR381LEG5vEzBjdkGn16CxxOoY0gpwiDvo12puJYEy83s5Xb2hfy6jTP2KzDP3HbYBTiZgFQkv4D4nPdfry8T6lUeIzx5PeoPORS-TQ</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Bleyer, Archie</creator><creator>Barr, Ronald</creator><creator>Hayes-Lattin, Brandon</creator><creator>Thomas, David</creator><creator>Ellis, Chad</creator><creator>Anderson, Barry</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>The distinctive biology of cancer in adolescents and young adults</title><author>Bleyer, Archie ; Barr, Ronald ; Hayes-Lattin, Brandon ; Thomas, David ; Ellis, Chad ; Anderson, Barry</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c556t-6fb1d18857533bee77ea487c1197ee5e7d885ec7bcc798a5d08ed033cdf05fb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cancer</topic><topic>Cancer Research</topic><topic>Care and treatment</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Medical examination</topic><topic>Methods</topic><topic>Neoplasms - pathology</topic><topic>review-article</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bleyer, Archie</creatorcontrib><creatorcontrib>Barr, Ronald</creatorcontrib><creatorcontrib>Hayes-Lattin, Brandon</creatorcontrib><creatorcontrib>Thomas, David</creatorcontrib><creatorcontrib>Ellis, Chad</creatorcontrib><creatorcontrib>Anderson, Barry</creatorcontrib><creatorcontrib>Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</creatorcontrib><creatorcontrib>on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature reviews. Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bleyer, Archie</au><au>Barr, Ronald</au><au>Hayes-Lattin, Brandon</au><au>Thomas, David</au><au>Ellis, Chad</au><au>Anderson, Barry</au><aucorp>Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</aucorp><aucorp>on behalf of the Biology and Clinical Trials Subgroups of the US National Cancer Institute Progress Review Group in Adolescent and Young Adult Oncology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The distinctive biology of cancer in adolescents and young adults</atitle><jtitle>Nature reviews. Cancer</jtitle><stitle>Nat Rev Cancer</stitle><addtitle>Nat Rev Cancer</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>8</volume><issue>4</issue><spage>288</spage><epage>298</epage><pages>288-298</pages><issn>1474-175X</issn><eissn>1474-1768</eissn><abstract>Key Points
The relative lack of progress in treating cancer in adolescents and young adults (AYAs) is in part due to a lack of appreciation of differences in the biology of malignant diseases in this age group relative to younger and older persons.
Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of AYAs, including leukaemias, lymphomas, sarcomas, melanoma, and carcinomas of the breast, colon, rectum and nasopharynx.
Translational and clinical research should not assume that the biology of cancers and AYA hosts is the same as in other age groups, even if the diseases seem the same clinically and histopathologically.
A systematic review of previously reported biological and therapeutic outcomes, that combines older adolescent and young adult patients with younger and older persons, should be made of biological differences if the numbers of subjects or samples permit an adequate assessment.
In addition, prospective studies evaluating potential biological differences should be incorporated into investigations that include patients across the age spectrum.
Therapeutic strategies tailored to the AYA age group, based on the distinct biology of the cancer and the host, might improve outcomes and prognosis.
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different. Do molecular, epidemiological and therapeutic outcome comparisons support this?
One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>18354417</pmid><doi>10.1038/nrc2349</doi><tpages>11</tpages></addata></record> |
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| ispartof | Nature reviews. Cancer, 2008-04, Vol.8 (4), p.288-298 |
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| subjects | Adolescent Adult Biomedical and Life Sciences Biomedicine Cancer Cancer Research Care and treatment Health aspects Humans Medical examination Methods Neoplasms - pathology review-article Young adults |
| title | The distinctive biology of cancer in adolescents and young adults |
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