Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymer for application in drug delivery
Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymers (PEOz–PLLA). PEOz–PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loa...
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| Veröffentlicht in: | International journal of pharmaceutics 2006-07, Vol.317 (1), p.69-75 |
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| creator | Hsiue, Ging-Ho Wang, Chun-Hung Lo, Chun-Liang Wang, Chau-Hui Li, Ju-Pi Yang, Jia-Ling |
| description | Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)-
b-poly(
l-lactide) diblock copolymers (PEOz–PLLA). PEOz–PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170
nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4–5). At 37
°C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24
h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72
h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-
b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy. |
| doi_str_mv | 10.1016/j.ijpharm.2006.03.002 |
| format | Article |
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b-poly(
l-lactide) diblock copolymers (PEOz–PLLA). PEOz–PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170
nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4–5). At 37
°C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24
h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72
h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-
b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2006.03.002</identifier><identifier>PMID: 16616820</identifier><identifier>CODEN: IJPHDE</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Antibiotics, Antineoplastic - administration & dosage ; Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - metabolism ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung ; Cell Line, Tumor ; Cell Survival - drug effects ; Diblock copolymers ; Doxorubicin - administration & dosage ; Doxorubicin - chemistry ; Doxorubicin - metabolism ; Drug delivery ; Drug Delivery Systems ; General pharmacology ; Humans ; Medical sciences ; Micelles ; Oxazoles - chemistry ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Poly( l-lactide) (PLLA) ; Poly(2-ethyl-2-oxazoline) (PEOz) ; Polyamines ; Polyesters - chemistry ; Polymeric micelle ; Polymers - chemistry</subject><ispartof>International journal of pharmaceutics, 2006-07, Vol.317 (1), p.69-75</ispartof><rights>2006 Elsevier B.V.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-b025ddd806353341c2745c3ebb5a19229bd8d477c931b6973427fb602e04409d3</citedby><cites>FETCH-LOGICAL-c490t-b025ddd806353341c2745c3ebb5a19229bd8d477c931b6973427fb602e04409d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378517306001979$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17899711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16616820$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hsiue, Ging-Ho</creatorcontrib><creatorcontrib>Wang, Chun-Hung</creatorcontrib><creatorcontrib>Lo, Chun-Liang</creatorcontrib><creatorcontrib>Wang, Chau-Hui</creatorcontrib><creatorcontrib>Li, Ju-Pi</creatorcontrib><creatorcontrib>Yang, Jia-Ling</creatorcontrib><title>Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymer for application in drug delivery</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)-
b-poly(
l-lactide) diblock copolymers (PEOz–PLLA). PEOz–PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170
nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4–5). At 37
°C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24
h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72
h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-
b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy.</description><subject>Antibiotics, Antineoplastic - administration & dosage</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung</subject><subject>Cell Line, Tumor</subject><subject>Cell Survival - drug effects</subject><subject>Diblock copolymers</subject><subject>Doxorubicin - administration & dosage</subject><subject>Doxorubicin - chemistry</subject><subject>Doxorubicin - metabolism</subject><subject>Drug delivery</subject><subject>Drug Delivery Systems</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Micelles</subject><subject>Oxazoles - chemistry</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Poly( l-lactide) (PLLA)</subject><subject>Poly(2-ethyl-2-oxazoline) (PEOz)</subject><subject>Polyamines</subject><subject>Polyesters - chemistry</subject><subject>Polymeric micelle</subject><subject>Polymers - chemistry</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1DAUQC0EokPhE0DegOjCwa_YyQqhqjykSmxgbTn2DfXgxMHOjBg-ga8mYSJ12dVd3HOfB6GXjFaMMvVuX4X9dGfzUHFKVUVFRSl_hHas0YIIqdVjtKNCN6RmWlygZ6Xs6QJyJp6iC6YUUw2nO_T3ZjyGnMYBxtlGUmAsYQ5HwENwECMU3NkCHqcRTyme3nIC890pEk7Sb_snxTDCFcEd-Z_EkUTr5uDhCvvQxeR-YpfW1AAZ9yljO00xODuHpV8Ysc-HH9hDXAbm03P0pLexwIstXqLvH2--XX8mt18_fbn-cEucbOlMOspr731DlaiFkMxxLWsnoOtqy1rO2843XmrtWsE61Wohue47RTlQKWnrxSV6c-475fTrAGU2QyjrsXaEdChGNbStZcMfBFkrpaobtoD1GXQ5lZKhN1MOg80nw6hZbZm92WyZ1Zahwiy2lrpX24BDN4C_r9r0LMDrDbDF2dhnO7pQ7jndtK1m6wLvzxwsfzsGyKa4AKMDHzK42fgUHljlH7i1tks</recordid><startdate>20060706</startdate><enddate>20060706</enddate><creator>Hsiue, Ging-Ho</creator><creator>Wang, Chun-Hung</creator><creator>Lo, Chun-Liang</creator><creator>Wang, Chau-Hui</creator><creator>Li, Ju-Pi</creator><creator>Yang, Jia-Ling</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20060706</creationdate><title>Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymer for application in drug delivery</title><author>Hsiue, Ging-Ho ; Wang, Chun-Hung ; Lo, Chun-Liang ; Wang, Chau-Hui ; Li, Ju-Pi ; Yang, Jia-Ling</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c490t-b025ddd806353341c2745c3ebb5a19229bd8d477c931b6973427fb602e04409d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Antibiotics, Antineoplastic - administration & dosage</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung</topic><topic>Cell Line, Tumor</topic><topic>Cell Survival - drug effects</topic><topic>Diblock copolymers</topic><topic>Doxorubicin - administration & dosage</topic><topic>Doxorubicin - chemistry</topic><topic>Doxorubicin - metabolism</topic><topic>Drug delivery</topic><topic>Drug Delivery Systems</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Micelles</topic><topic>Oxazoles - chemistry</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Poly( l-lactide) (PLLA)</topic><topic>Poly(2-ethyl-2-oxazoline) (PEOz)</topic><topic>Polyamines</topic><topic>Polyesters - chemistry</topic><topic>Polymeric micelle</topic><topic>Polymers - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hsiue, Ging-Ho</creatorcontrib><creatorcontrib>Wang, Chun-Hung</creatorcontrib><creatorcontrib>Lo, Chun-Liang</creatorcontrib><creatorcontrib>Wang, Chau-Hui</creatorcontrib><creatorcontrib>Li, Ju-Pi</creatorcontrib><creatorcontrib>Yang, Jia-Ling</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hsiue, Ging-Ho</au><au>Wang, Chun-Hung</au><au>Lo, Chun-Liang</au><au>Wang, Chau-Hui</au><au>Li, Ju-Pi</au><au>Yang, Jia-Ling</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymer for application in drug delivery</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2006-07-06</date><risdate>2006</risdate><volume>317</volume><issue>1</issue><spage>69</spage><epage>75</epage><pages>69-75</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><coden>IJPHDE</coden><abstract>Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)-
b-poly(
l-lactide) diblock copolymers (PEOz–PLLA). PEOz–PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170
nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4–5). At 37
°C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24
h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72
h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-
b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>16616820</pmid><doi>10.1016/j.ijpharm.2006.03.002</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | International journal of pharmaceutics, 2006-07, Vol.317 (1), p.69-75 |
| issn | 0378-5173 1873-3476 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibiotics, Antineoplastic - administration & dosage Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - metabolism Biological and medical sciences Carcinoma, Non-Small-Cell Lung Cell Line, Tumor Cell Survival - drug effects Diblock copolymers Doxorubicin - administration & dosage Doxorubicin - chemistry Doxorubicin - metabolism Drug delivery Drug Delivery Systems General pharmacology Humans Medical sciences Micelles Oxazoles - chemistry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Poly( l-lactide) (PLLA) Poly(2-ethyl-2-oxazoline) (PEOz) Polyamines Polyesters - chemistry Polymeric micelle Polymers - chemistry |
| title | Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)- b-poly( l-lactide) diblock copolymer for application in drug delivery |
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