Cdc25: mechanisms of checkpoint inhibition and recovery

Members of the eukaryotic Cdc25 phosphatase family are key targets of the Chk1 and Chk2 checkpoint kinases, which inactivate Cdc25 to halt cell cycle progression when DNA is damaged or incompletely replicated. Now, new kinases that phosphorylate and inactivate Cdc25 are being discovered, including M...

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Veröffentlicht in:	Trends in cell biology 2006-06, Vol.16 (6), p.285-292
Hauptverfasser:	Karlsson-Rosenthal, Christina, Millar, Jonathan B.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Calmodulin-Dependent Protein Kinases - metabolism cdc25 Phosphatases - physiology Cell Cycle - physiology Cell Cycle Proteins - physiology Checkpoint Kinase 2 DNA Damage Humans Intracellular Signaling Peptides and Proteins Models, Genetic p38 Mitogen-Activated Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Protein-Serine-Threonine Kinases - physiology Schizosaccharomyces pombe Proteins - physiology Spindle Apparatus - physiology
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