Evaluation of mismatch-binding ligands as inhibitors for Rev–RRE interaction

Mismatches in stem-loop IIB of RRE of HIV-1 are the site of Rev binding. Molecules binding to G-G and G-A mismatches in DNA were evaluated as inhibitors of RRE–Rev interaction. Drugs targeting the stem-loop IIB of Rev responsible element (RRE) of HIV-1 mRNA are potential therapeutic agents for HIV-1...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-08, Vol.14 (15), p.5384-5388
Hauptverfasser:	Nakatani, Kazuhiko, Horie, Souta, Goto, Yuki, Kobori, Akio, Hagihara, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Base Pair Mismatch Base Sequence Binding Sites Binding, Competitive - drug effects Biological and medical sciences DNA - chemistry DNA - drug effects Drug design Drug Evaluation, Preclinical Fluorescence Polarization Gene Products, rev - antagonists & inhibitors Gene Products, rev - chemistry Genes, env - drug effects Genes, env - genetics HIV-1 - genetics HIV-1 RRE Inhibitors Ligands Medical sciences Molecular Sequence Data Molecular Structure Naphthyridines - chemistry Naphthyridines - pharmacology Nucleic Acid Conformation Pharmacology. Drug treatments Polyamines - chemistry Polyamines - pharmacology Protein Binding - drug effects Quinolones - chemistry Quinolones - pharmacology rev Gene Products, Human Immunodeficiency Virus RNA recognition RNA, Viral - chemistry RNA, Viral - drug effects Surface Plasmon Resonance Time Factors
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