Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia
Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subg...
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| Veröffentlicht in: | Transactions of the Royal Society of Tropical Medicine and Hygiene 2006-08, Vol.100 (8), p.791-794 |
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| creator | Nchito, M. Friis, H. Michaelsen, K.F. Mubila, L. Olsen, A. |
| description | Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months’ follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21,
P
=
0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies. |
| doi_str_mv | 10.1016/j.trstmh.2005.10.016 |
| format | Article |
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P
=
0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies.</description><identifier>ISSN: 0035-9203</identifier><identifier>EISSN: 1878-3503</identifier><identifier>DOI: 10.1016/j.trstmh.2005.10.016</identifier><identifier>PMID: 16540136</identifier><identifier>CODEN: TRSTAZ</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adolescent ; Ascaris lumbricoides ; Biological and medical sciences ; Child ; Dietary Supplements - adverse effects ; Double-Blind Method ; Female ; Follow-Up Studies ; General aspects ; Geophagy ; Humans ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - metabolism ; Intestinal permeability ; Iron ; Iron - pharmacology ; Lactulose - urine ; Male ; Mannitol - urine ; Medical sciences ; Micronutrients - pharmacology ; Multi-micronutrients ; Permeability - drug effects ; Schoolchildren ; Zambia</subject><ispartof>Transactions of the Royal Society of Tropical Medicine and Hygiene, 2006-08, Vol.100 (8), p.791-794</ispartof><rights>2005 Royal Society of Tropical Medicine and Hygiene</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-938ffdbf3910cc7fbb1358255c97e589f8ba00ce8c7d53a2458c363f78bac4783</citedby><cites>FETCH-LOGICAL-c474t-938ffdbf3910cc7fbb1358255c97e589f8ba00ce8c7d53a2458c363f78bac4783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17930533$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16540136$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nchito, M.</creatorcontrib><creatorcontrib>Friis, H.</creatorcontrib><creatorcontrib>Michaelsen, K.F.</creatorcontrib><creatorcontrib>Mubila, L.</creatorcontrib><creatorcontrib>Olsen, A.</creatorcontrib><title>Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia</title><title>Transactions of the Royal Society of Tropical Medicine and Hygiene</title><addtitle>Trans R Soc Trop Med Hyg</addtitle><description>Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months’ follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21,
P
=
0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies.</description><subject>Adolescent</subject><subject>Ascaris lumbricoides</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Dietary Supplements - adverse effects</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Geophagy</subject><subject>Humans</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestinal permeability</subject><subject>Iron</subject><subject>Iron - pharmacology</subject><subject>Lactulose - urine</subject><subject>Male</subject><subject>Mannitol - urine</subject><subject>Medical sciences</subject><subject>Micronutrients - pharmacology</subject><subject>Multi-micronutrients</subject><subject>Permeability - drug effects</subject><subject>Schoolchildren</subject><subject>Zambia</subject><issn>0035-9203</issn><issn>1878-3503</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF2L1DAUhoMo7rj6D0R6417ZMWmaJr0RZFndhYEVP0DmJqTpqZPZ9MOcVHb_vRla3Duvwnny5OXkJeQ1o1tGWfX-uI0BY3_YFpSKhLYJPiEbpqTKuaD8KdlQykVeF5SfkReIR0oLwUT9nJyxSpSU8WpDft2EcchwniYPPQzRRJdmN9gABgEz7I33aY6A0Q2QTRB6MI3zLj4knE3B9SY8ZGgP4-jtwfk2wCkg281o7sy7bG_6xpmX5FlnPMKr9TwnPz5dfb-8zne3n28uP-5yW8oy5jVXXdc2Ha8ZtVZ2TcO4UIUQtpYgVN2pxlBqQVnZCm6KUijLK97JxFOC4ufkYsmdwvh7Tkvr3qEF780A44y6UrQuWVElsVxEG0bEAJ1ev6IZ1aeC9VEvBetTwSeaYHr2Zs2fmx7ax0dro0l4uwoGrfFdMIN1-OjJmlPBefLyxXMY4f7fvQl3upJcCn39c6-_fZWs-FLt9T75HxYfUnt_HASN1sFgoXUBbNTt6P6_-V8-r6zU</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Nchito, M.</creator><creator>Friis, H.</creator><creator>Michaelsen, K.F.</creator><creator>Mubila, L.</creator><creator>Olsen, A.</creator><general>Elsevier Ltd</general><general>Royal Society of Tropical Medicine and Hygiene</general><general>Elsevier</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060801</creationdate><title>Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia</title><author>Nchito, M. ; Friis, H. ; Michaelsen, K.F. ; Mubila, L. ; Olsen, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-938ffdbf3910cc7fbb1358255c97e589f8ba00ce8c7d53a2458c363f78bac4783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Ascaris lumbricoides</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Dietary Supplements - adverse effects</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Geophagy</topic><topic>Humans</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestinal permeability</topic><topic>Iron</topic><topic>Iron - pharmacology</topic><topic>Lactulose - urine</topic><topic>Male</topic><topic>Mannitol - urine</topic><topic>Medical sciences</topic><topic>Micronutrients - pharmacology</topic><topic>Multi-micronutrients</topic><topic>Permeability - drug effects</topic><topic>Schoolchildren</topic><topic>Zambia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nchito, M.</creatorcontrib><creatorcontrib>Friis, H.</creatorcontrib><creatorcontrib>Michaelsen, K.F.</creatorcontrib><creatorcontrib>Mubila, L.</creatorcontrib><creatorcontrib>Olsen, A.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nchito, M.</au><au>Friis, H.</au><au>Michaelsen, K.F.</au><au>Mubila, L.</au><au>Olsen, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia</atitle><jtitle>Transactions of the Royal Society of Tropical Medicine and Hygiene</jtitle><addtitle>Trans R Soc Trop Med Hyg</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>100</volume><issue>8</issue><spage>791</spage><epage>794</epage><pages>791-794</pages><issn>0035-9203</issn><eissn>1878-3503</eissn><coden>TRSTAZ</coden><abstract>Elevated intestinal permeability, measured as an increased lactulose:mannitol (L:M) ratio, indicates injury of the small intestinal mucosa. As part of a randomized iron and multi-micronutrient (without iron) supplementation trial (Nchito et al., 2004), we determined intestinal permeability in a subgroup of schoolchildren at 10 months’ follow-up to assess the effect of the interventions. Among 153 children (mean age 10.2 years and 53.6% girls) iron supplementation resulted in a higher L:M ratio compared with placebo (0.29 vs. 0.21,
P
=
0.025). There was no effect of multi-micronutrient supplementation, and no interaction between the interventions. The finding could be one of the mechanisms explaining the negative effects of medicinal iron supplementation on morbidity found in some other studies.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16540136</pmid><doi>10.1016/j.trstmh.2005.10.016</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Ascaris lumbricoides Biological and medical sciences Child Dietary Supplements - adverse effects Double-Blind Method Female Follow-Up Studies General aspects Geophagy Humans Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal permeability Iron Iron - pharmacology Lactulose - urine Male Mannitol - urine Medical sciences Micronutrients - pharmacology Multi-micronutrients Permeability - drug effects Schoolchildren Zambia |
| title | Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia |
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