Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin
Ghrelin, a 28-residue octanoylated peptide recently isolated from the stomach, exhibits anti-cachectic properties through regulating food intake, energy expenditure, adiposity, growth hormone secretion and immune response. Burn injury induces persistent hypermetabolism and muscle wasting. We therefo...
Gespeichert in:
| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2006-07, Vol.27 (7), p.1624-1631 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1631 |
|---|---|
| container_issue | 7 |
| container_start_page | 1624 |
| container_title | Peptides (New York, N.Y. : 1980) |
| container_volume | 27 |
| creator | Balasubramaniam, Ambikaipakan Wood, Steve Joshi, Rashika Su, Chunhua Friend, Lou Ann Sheriff, Sulaiman James, J. Howard |
| description | Ghrelin, a 28-residue octanoylated peptide recently isolated from the stomach, exhibits anti-cachectic properties through regulating food intake, energy expenditure, adiposity, growth hormone secretion and immune response. Burn injury induces persistent hypermetabolism and muscle wasting. We therefore hypothesized that ghrelin may also play a role in the pathophysiology of burn-induced cachexia. Overall ghrelin expression in the stomach over 10 days after burn was significantly decreased (
p
=
0.0003). Total plasma ghrelin was reduced 1 day after burn. Thus, changes in ghrelin synthesis and release may contribute to burn-induced dysfunctions. Ghrelin (30
nmol/rat, i.p.) greatly stimulated 2
h food intake in rats on five separate days after burn and in control rats. On post-burn day 15, plasma growth hormone levels were significantly lower than in controls, and this was restored to normal levels by ghrelin (10
nmol/rat, i.p.). These observations suggest that ghrelin retains its ability to favorably modulate both the peripheral anabolic and the central orexigenic signals, even after thermal injury despite ongoing changes due to prolonged and profound hypermetabolism, suggesting that long-term treatment with ghrelin may attenuate burn-induced dysfunctions. |
| doi_str_mv | 10.1016/j.peptides.2006.02.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68092746</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196978106001008</els_id><sourcerecordid>68092746</sourcerecordid><originalsourceid>FETCH-LOGICAL-c396t-d74531a67782411f2b77fdcceb9bccd1c5b65da234e504b030e81d40ace82ea3</originalsourceid><addsrcrecordid>eNqFkE1v1DAQhq0KRJfCX6h8gVvC2HHshBOoagtSJQ70bjn2pOttEm9th2r_Pa52UY-cRnrnmQ89hFwyqBkw-WVX73GfvcNUcwBZA68B2jOyYZ1qqpbJ_g3ZAOtl1auOnZP3Ke0AQIi-e0fOmWyV4EptyOPtNuLkF5qyn9fJZEx0DMFRv2TziNQsjj7E8Jy3dBviHBakhUeTsBA0mpzosy_NvMU4m6mEuzUevtLfh6VEyScaRvpwvPGBvB3NlPDjqV6Q-5vr-6sf1d2v259X3-8q2_QyV06JtmFGKtVxwdjIB6VGZy0O_WCtY7YdZOsMbwS2IAZoADvmBBiLHUfTXJDPx7X7GJ5WTFnPPlmcJrNgWJOWHfRcCVlAeQRtDClFHPU--tnEg2agXyzrnf5nWb9Y1sB1sVwGL08X1mFG9zp20lqATyfAJGumMZrF-vTKqR4k7_rCfTtyWHT88Rh1sh4Xi85HtFm74P_3y188taEM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68092746</pqid></control><display><type>article</type><title>Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Balasubramaniam, Ambikaipakan ; Wood, Steve ; Joshi, Rashika ; Su, Chunhua ; Friend, Lou Ann ; Sheriff, Sulaiman ; James, J. Howard</creator><creatorcontrib>Balasubramaniam, Ambikaipakan ; Wood, Steve ; Joshi, Rashika ; Su, Chunhua ; Friend, Lou Ann ; Sheriff, Sulaiman ; James, J. Howard</creatorcontrib><description>Ghrelin, a 28-residue octanoylated peptide recently isolated from the stomach, exhibits anti-cachectic properties through regulating food intake, energy expenditure, adiposity, growth hormone secretion and immune response. Burn injury induces persistent hypermetabolism and muscle wasting. We therefore hypothesized that ghrelin may also play a role in the pathophysiology of burn-induced cachexia. Overall ghrelin expression in the stomach over 10 days after burn was significantly decreased (
p
=
0.0003). Total plasma ghrelin was reduced 1 day after burn. Thus, changes in ghrelin synthesis and release may contribute to burn-induced dysfunctions. Ghrelin (30
nmol/rat, i.p.) greatly stimulated 2
h food intake in rats on five separate days after burn and in control rats. On post-burn day 15, plasma growth hormone levels were significantly lower than in controls, and this was restored to normal levels by ghrelin (10
nmol/rat, i.p.). These observations suggest that ghrelin retains its ability to favorably modulate both the peripheral anabolic and the central orexigenic signals, even after thermal injury despite ongoing changes due to prolonged and profound hypermetabolism, suggesting that long-term treatment with ghrelin may attenuate burn-induced dysfunctions.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/j.peptides.2006.02.005</identifier><identifier>PMID: 16574277</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Burn injury ; Burns - pathology ; Cachexia - pathology ; Eating ; Food intake ; Fundamental and applied biological sciences. Psychology ; Ghrelin ; Growth hormone ; Growth Hormone - pharmacokinetics ; Hot Temperature ; Male ; Models, Biological ; Peptide Hormones - biosynthesis ; Peptide Hormones - chemistry ; Peptide Hormones - metabolism ; Peptide Hormones - physiology ; Peptides - chemistry ; Rats ; Rats, Sprague-Dawley ; Solid phase synthesis ; Stomach - metabolism ; Time Factors ; Vertebrates: endocrinology</subject><ispartof>Peptides (New York, N.Y. : 1980), 2006-07, Vol.27 (7), p.1624-1631</ispartof><rights>2006 Elsevier Inc.</rights><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-d74531a67782411f2b77fdcceb9bccd1c5b65da234e504b030e81d40ace82ea3</citedby><cites>FETCH-LOGICAL-c396t-d74531a67782411f2b77fdcceb9bccd1c5b65da234e504b030e81d40ace82ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.peptides.2006.02.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17906289$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16574277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balasubramaniam, Ambikaipakan</creatorcontrib><creatorcontrib>Wood, Steve</creatorcontrib><creatorcontrib>Joshi, Rashika</creatorcontrib><creatorcontrib>Su, Chunhua</creatorcontrib><creatorcontrib>Friend, Lou Ann</creatorcontrib><creatorcontrib>Sheriff, Sulaiman</creatorcontrib><creatorcontrib>James, J. Howard</creatorcontrib><title>Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>Ghrelin, a 28-residue octanoylated peptide recently isolated from the stomach, exhibits anti-cachectic properties through regulating food intake, energy expenditure, adiposity, growth hormone secretion and immune response. Burn injury induces persistent hypermetabolism and muscle wasting. We therefore hypothesized that ghrelin may also play a role in the pathophysiology of burn-induced cachexia. Overall ghrelin expression in the stomach over 10 days after burn was significantly decreased (
p
=
0.0003). Total plasma ghrelin was reduced 1 day after burn. Thus, changes in ghrelin synthesis and release may contribute to burn-induced dysfunctions. Ghrelin (30
nmol/rat, i.p.) greatly stimulated 2
h food intake in rats on five separate days after burn and in control rats. On post-burn day 15, plasma growth hormone levels were significantly lower than in controls, and this was restored to normal levels by ghrelin (10
nmol/rat, i.p.). These observations suggest that ghrelin retains its ability to favorably modulate both the peripheral anabolic and the central orexigenic signals, even after thermal injury despite ongoing changes due to prolonged and profound hypermetabolism, suggesting that long-term treatment with ghrelin may attenuate burn-induced dysfunctions.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Burn injury</subject><subject>Burns - pathology</subject><subject>Cachexia - pathology</subject><subject>Eating</subject><subject>Food intake</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Ghrelin</subject><subject>Growth hormone</subject><subject>Growth Hormone - pharmacokinetics</subject><subject>Hot Temperature</subject><subject>Male</subject><subject>Models, Biological</subject><subject>Peptide Hormones - biosynthesis</subject><subject>Peptide Hormones - chemistry</subject><subject>Peptide Hormones - metabolism</subject><subject>Peptide Hormones - physiology</subject><subject>Peptides - chemistry</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Solid phase synthesis</subject><subject>Stomach - metabolism</subject><subject>Time Factors</subject><subject>Vertebrates: endocrinology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhq0KRJfCX6h8gVvC2HHshBOoagtSJQ70bjn2pOttEm9th2r_Pa52UY-cRnrnmQ89hFwyqBkw-WVX73GfvcNUcwBZA68B2jOyYZ1qqpbJ_g3ZAOtl1auOnZP3Ke0AQIi-e0fOmWyV4EptyOPtNuLkF5qyn9fJZEx0DMFRv2TziNQsjj7E8Jy3dBviHBakhUeTsBA0mpzosy_NvMU4m6mEuzUevtLfh6VEyScaRvpwvPGBvB3NlPDjqV6Q-5vr-6sf1d2v259X3-8q2_QyV06JtmFGKtVxwdjIB6VGZy0O_WCtY7YdZOsMbwS2IAZoADvmBBiLHUfTXJDPx7X7GJ5WTFnPPlmcJrNgWJOWHfRcCVlAeQRtDClFHPU--tnEg2agXyzrnf5nWb9Y1sB1sVwGL08X1mFG9zp20lqATyfAJGumMZrF-vTKqR4k7_rCfTtyWHT88Rh1sh4Xi85HtFm74P_3y188taEM</recordid><startdate>20060701</startdate><enddate>20060701</enddate><creator>Balasubramaniam, Ambikaipakan</creator><creator>Wood, Steve</creator><creator>Joshi, Rashika</creator><creator>Su, Chunhua</creator><creator>Friend, Lou Ann</creator><creator>Sheriff, Sulaiman</creator><creator>James, J. Howard</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060701</creationdate><title>Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin</title><author>Balasubramaniam, Ambikaipakan ; Wood, Steve ; Joshi, Rashika ; Su, Chunhua ; Friend, Lou Ann ; Sheriff, Sulaiman ; James, J. Howard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-d74531a67782411f2b77fdcceb9bccd1c5b65da234e504b030e81d40ace82ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Burn injury</topic><topic>Burns - pathology</topic><topic>Cachexia - pathology</topic><topic>Eating</topic><topic>Food intake</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Ghrelin</topic><topic>Growth hormone</topic><topic>Growth Hormone - pharmacokinetics</topic><topic>Hot Temperature</topic><topic>Male</topic><topic>Models, Biological</topic><topic>Peptide Hormones - biosynthesis</topic><topic>Peptide Hormones - chemistry</topic><topic>Peptide Hormones - metabolism</topic><topic>Peptide Hormones - physiology</topic><topic>Peptides - chemistry</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Solid phase synthesis</topic><topic>Stomach - metabolism</topic><topic>Time Factors</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balasubramaniam, Ambikaipakan</creatorcontrib><creatorcontrib>Wood, Steve</creatorcontrib><creatorcontrib>Joshi, Rashika</creatorcontrib><creatorcontrib>Su, Chunhua</creatorcontrib><creatorcontrib>Friend, Lou Ann</creatorcontrib><creatorcontrib>Sheriff, Sulaiman</creatorcontrib><creatorcontrib>James, J. Howard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balasubramaniam, Ambikaipakan</au><au>Wood, Steve</au><au>Joshi, Rashika</au><au>Su, Chunhua</au><au>Friend, Lou Ann</au><au>Sheriff, Sulaiman</au><au>James, J. Howard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>2006-07-01</date><risdate>2006</risdate><volume>27</volume><issue>7</issue><spage>1624</spage><epage>1631</epage><pages>1624-1631</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>Ghrelin, a 28-residue octanoylated peptide recently isolated from the stomach, exhibits anti-cachectic properties through regulating food intake, energy expenditure, adiposity, growth hormone secretion and immune response. Burn injury induces persistent hypermetabolism and muscle wasting. We therefore hypothesized that ghrelin may also play a role in the pathophysiology of burn-induced cachexia. Overall ghrelin expression in the stomach over 10 days after burn was significantly decreased (
p
=
0.0003). Total plasma ghrelin was reduced 1 day after burn. Thus, changes in ghrelin synthesis and release may contribute to burn-induced dysfunctions. Ghrelin (30
nmol/rat, i.p.) greatly stimulated 2
h food intake in rats on five separate days after burn and in control rats. On post-burn day 15, plasma growth hormone levels were significantly lower than in controls, and this was restored to normal levels by ghrelin (10
nmol/rat, i.p.). These observations suggest that ghrelin retains its ability to favorably modulate both the peripheral anabolic and the central orexigenic signals, even after thermal injury despite ongoing changes due to prolonged and profound hypermetabolism, suggesting that long-term treatment with ghrelin may attenuate burn-induced dysfunctions.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>16574277</pmid><doi>10.1016/j.peptides.2006.02.005</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-9781 |
| ispartof | Peptides (New York, N.Y. : 1980), 2006-07, Vol.27 (7), p.1624-1631 |
| issn | 0196-9781 1873-5169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_68092746 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Burn injury Burns - pathology Cachexia - pathology Eating Food intake Fundamental and applied biological sciences. Psychology Ghrelin Growth hormone Growth Hormone - pharmacokinetics Hot Temperature Male Models, Biological Peptide Hormones - biosynthesis Peptide Hormones - chemistry Peptide Hormones - metabolism Peptide Hormones - physiology Peptides - chemistry Rats Rats, Sprague-Dawley Solid phase synthesis Stomach - metabolism Time Factors Vertebrates: endocrinology |
| title | Ghrelin stimulates food intake and growth hormone release in rats with thermal injury: Synthesis of ghrelin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T11%3A08%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Ghrelin%20stimulates%20food%20intake%20and%20growth%20hormone%20release%20in%20rats%20with%20thermal%20injury:%20Synthesis%20of%20ghrelin&rft.jtitle=Peptides%20(New%20York,%20N.Y.%20:%201980)&rft.au=Balasubramaniam,%20Ambikaipakan&rft.date=2006-07-01&rft.volume=27&rft.issue=7&rft.spage=1624&rft.epage=1631&rft.pages=1624-1631&rft.issn=0196-9781&rft.eissn=1873-5169&rft.coden=PPTDD5&rft_id=info:doi/10.1016/j.peptides.2006.02.005&rft_dat=%3Cproquest_cross%3E68092746%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=68092746&rft_id=info:pmid/16574277&rft_els_id=S0196978106001008&rfr_iscdi=true |