A New Mechanism Involving ERK Contributes to Rosiglitazone Inhibition of Tumor Necrosis Factor-α and Interferon-γ Inflammatory Effects in Human Endothelial Cells

OBJECTIVE—Microvascular endothelium is one of the main targets of the inflammatory response. On specific activation, endothelial cells recruit Th1-lymphocytes at the inflammatory site. We investigated the intracellular signaling mediating tumor necrosis factor (TNF)-α and interferon (IFN)-γ inflamma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2008-04, Vol.28 (4), p.718-724
Hauptverfasser:	Lombardi, Adriana, Cantini, Giulia, Piscitelli, Elisabetta, Gelmini, Stefania, Francalanci, Michela, Mello, Tommaso, Ceni, Elisabetta, Varano, Gabriele, Forti, Gianni, Rotondi, Mario, Galli, Andrea, Serio, Mario, Luconi, Michaela
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Blood vessels and receptors Cardiology. Vascular system Cell Line Chemokine CXCL10 - metabolism Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endothelial Cells - drug effects Endothelial Cells - immunology Endothelial Cells - metabolism Endothelial Cells - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Fundamental and applied biological sciences. Psychology Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Interferon-gamma - antagonists & inhibitors Interferon-gamma - biosynthesis MAP Kinase Signaling System - drug effects Medical sciences PPAR gamma - metabolism Signal Transduction - drug effects Th1 Cells - drug effects Th1 Cells - immunology Thiazolidinediones - metabolism Thiazolidinediones - pharmacology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Vertebrates: cardiovascular system
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!