Molecular pathobiology of gastrointestinal stromal sarcomas

Gastrointestinal stromal tumors (GISTs) form an interesting group of sarcomas whose unique pathobiology provides a model of how molecularly targeted therapeutics can have a major impact on patient welfare. Approximately 85% of GISTs are driven by oncogenic mutations in either of two receptor tyrosin...

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Veröffentlicht in:	Annual review of pathology 2008-01, Vol.3 (1), p.557-586
Hauptverfasser:	Corless, Christopher L, Heinrich, Michael C
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzamides Gastrointestinal Stromal Tumors - drug therapy Gastrointestinal Stromal Tumors - genetics Gastrointestinal Stromal Tumors - pathology Gene Expression Regulation, Neoplastic Humans Imatinib Mesylate Indoles - therapeutic use Mutation Piperazines - therapeutic use Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - metabolism Pyrimidines - therapeutic use Pyrroles - therapeutic use Receptor, Platelet-Derived Growth Factor alpha - genetics Receptor, Platelet-Derived Growth Factor alpha - metabolism Sarcoma - drug therapy Sarcoma - genetics Sarcoma - pathology
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