Trastuzumab-modified nanoparticles: Optimisation of preparation and uptake in cancer cells

Nanoparticles consisting of human serum albumin (HSA) represent a promising strategy for targeted drug delivery to tumour cells. The coupling of the antibody trastuzumab to HSA nanoparticles takes advantage of the capability of HER2-positive cells to incorporate substances binding to HER2. In our pr...

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Veröffentlicht in:	Biomaterials 2006-10, Vol.27 (28), p.4975-4983
Hauptverfasser:	Steinhauser, Isabel, Spänkuch, Birgit, Strebhardt, Klaus, Langer, Klaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Albumin Antibodies, Monoclonal - chemistry Antibodies, Monoclonal - pharmacokinetics Antibodies, Monoclonal, Humanized Blotting, Western Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Delayed-Action Preparations - pharmacokinetics Drug Carriers - chemistry Drug Carriers - pharmacokinetics Drug delivery Flow cytometry Flow Cytometry - methods Humans Molecular Structure Nanoparticle Nanostructures - chemistry Nanotechnology Receptor, ErbB-2 - immunology Surface modification Thiol Trastuzumab
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