Synthesis and biological evaluation of novel PDMP analogues

A new series of hybrid PDMP analogues, based both on PDMP and styryl analogues of natural ceramide, has been synthesized from d-serine. The synthetic route was developed such that future introduction of different aryl groups is straightforward. Biological evaluation, both in vitro on rat liver Golgi...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-08, Vol.14 (15), p.5273-5284
Hauptverfasser:	Hillaert, Ulrik, Boldin-Adamsky, Swetlana, Rozenski, Jef, Busson, Roger, Futerman, Anthony H., Calenbergh, Serge Van
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Cell Proliferation - drug effects Cercopithecus aethiops COS Cells C–C coupling Dose-Response Relationship, Drug Drug Evaluation, Preclinical Enzyme Inhibitors - chemical synthesis Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Glucosylceramide synthase Glucosyltransferases - antagonists & inhibitors Golgi Apparatus - drug effects Golgi Apparatus - enzymology Humans Inhibitor Liver - drug effects Liver - enzymology Medical sciences Miscellaneous Molecular Structure Morpholines - chemistry Morpholines - pharmacology PDMP Pharmacology. Drug treatments Rats Sphingolipids Structure-Activity Relationship Subcellular Fractions - enzymology
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