The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits
The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided in...
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| Veröffentlicht in: | Journal of inorganic biochemistry 2005-08, Vol.99 (8), p.1733-1737 |
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| creator | Liu, Ping Yao, Yu-Na Wu, Shi-De Dong, Huai-Jun Feng, Guo-Chang Yuan, Xiao-Yan |
| description | The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al
+
DE. The Al-only and Al
+
DE animals received injections of Al
2(SO
4)
3
·
18H
2O 600
μmol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al
+
DE rabbits were given deferiprone 750
μmol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al
+
DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration. |
| doi_str_mv | 10.1016/j.jinorgbio.2005.06.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_68090147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0162013405001649</els_id><sourcerecordid>68090147</sourcerecordid><originalsourceid>FETCH-LOGICAL-c369t-12276db9b43df5d80f254179b672e969318ed640e2ce41722827c7b769286ff63</originalsourceid><addsrcrecordid>eNqFkE1v3CAQhlGVqtmk_QsJp5zWLmAM5hhF6YcUqZf0jDAMKSsbNmCvlP76Eu0qPeY00uiZmXcehK4paSmh4uuu3YWY8tMYUssI6VsiWkLYB7Shg-yaruP8DG0qyRpCO36OLkrZkQr2XH5C51QQ3ivFNsg9_gEM3gdr7AtOHjvwkMM-pwg4RbyEUlYo2EzrHOI64wxzOpgJm-iwTfs95C3-G6Ld4tnEJxOhAJ7gABMOEWczjmEpn9FHb6YCX071Ev3-dv9496N5-PX9593tQ2M7oZaGMiaFG9XIO-d7NxDPek6lGoVkoITq6ABOcALMQu0zNjBp5SiFYoPwXnSX6Oa4t8Z_rqkXPYdiYZpqrLQWLQaiCOWygvII2pxKyeD1PofZ5BdNiX4VrHf6TbB-FayJ0FVwnbw6nVjHGdz_uZPRCtweAaiPHgJkXWyAaMGFDHbRLoV3j_wDgWKQyA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>68090147</pqid></control><display><type>article</type><title>The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Liu, Ping ; Yao, Yu-Na ; Wu, Shi-De ; Dong, Huai-Jun ; Feng, Guo-Chang ; Yuan, Xiao-Yan</creator><creatorcontrib>Liu, Ping ; Yao, Yu-Na ; Wu, Shi-De ; Dong, Huai-Jun ; Feng, Guo-Chang ; Yuan, Xiao-Yan</creatorcontrib><description>The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al
+
DE. The Al-only and Al
+
DE animals received injections of Al
2(SO
4)
3
·
18H
2O 600
μmol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al
+
DE rabbits were given deferiprone 750
μmol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al
+
DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration.</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2005.06.002</identifier><identifier>PMID: 16045992</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aluminum ; Aluminum - administration & dosage ; Aluminum - blood ; Aluminum - pharmacokinetics ; Aluminum - pharmacology ; Animals ; Body Weight - drug effects ; Copper - blood ; Copper - metabolism ; Deferiprone ; Manganese - blood ; Manganese - metabolism ; Pyridones - pharmacology ; Rabbits ; Spectrum Analysis ; Trace elements ; Zinc - blood ; Zinc - metabolism</subject><ispartof>Journal of inorganic biochemistry, 2005-08, Vol.99 (8), p.1733-1737</ispartof><rights>2005 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-12276db9b43df5d80f254179b672e969318ed640e2ce41722827c7b769286ff63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinorgbio.2005.06.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16045992$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Yao, Yu-Na</creatorcontrib><creatorcontrib>Wu, Shi-De</creatorcontrib><creatorcontrib>Dong, Huai-Jun</creatorcontrib><creatorcontrib>Feng, Guo-Chang</creatorcontrib><creatorcontrib>Yuan, Xiao-Yan</creatorcontrib><title>The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al
+
DE. The Al-only and Al
+
DE animals received injections of Al
2(SO
4)
3
·
18H
2O 600
μmol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al
+
DE rabbits were given deferiprone 750
μmol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al
+
DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration.</description><subject>Aluminum</subject><subject>Aluminum - administration & dosage</subject><subject>Aluminum - blood</subject><subject>Aluminum - pharmacokinetics</subject><subject>Aluminum - pharmacology</subject><subject>Animals</subject><subject>Body Weight - drug effects</subject><subject>Copper - blood</subject><subject>Copper - metabolism</subject><subject>Deferiprone</subject><subject>Manganese - blood</subject><subject>Manganese - metabolism</subject><subject>Pyridones - pharmacology</subject><subject>Rabbits</subject><subject>Spectrum Analysis</subject><subject>Trace elements</subject><subject>Zinc - blood</subject><subject>Zinc - metabolism</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v3CAQhlGVqtmk_QsJp5zWLmAM5hhF6YcUqZf0jDAMKSsbNmCvlP76Eu0qPeY00uiZmXcehK4paSmh4uuu3YWY8tMYUssI6VsiWkLYB7Shg-yaruP8DG0qyRpCO36OLkrZkQr2XH5C51QQ3ivFNsg9_gEM3gdr7AtOHjvwkMM-pwg4RbyEUlYo2EzrHOI64wxzOpgJm-iwTfs95C3-G6Ld4tnEJxOhAJ7gABMOEWczjmEpn9FHb6YCX071Ev3-dv9496N5-PX9593tQ2M7oZaGMiaFG9XIO-d7NxDPek6lGoVkoITq6ABOcALMQu0zNjBp5SiFYoPwXnSX6Oa4t8Z_rqkXPYdiYZpqrLQWLQaiCOWygvII2pxKyeD1PofZ5BdNiX4VrHf6TbB-FayJ0FVwnbw6nVjHGdz_uZPRCtweAaiPHgJkXWyAaMGFDHbRLoV3j_wDgWKQyA</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Liu, Ping</creator><creator>Yao, Yu-Na</creator><creator>Wu, Shi-De</creator><creator>Dong, Huai-Jun</creator><creator>Feng, Guo-Chang</creator><creator>Yuan, Xiao-Yan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits</title><author>Liu, Ping ; Yao, Yu-Na ; Wu, Shi-De ; Dong, Huai-Jun ; Feng, Guo-Chang ; Yuan, Xiao-Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-12276db9b43df5d80f254179b672e969318ed640e2ce41722827c7b769286ff63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Aluminum</topic><topic>Aluminum - administration & dosage</topic><topic>Aluminum - blood</topic><topic>Aluminum - pharmacokinetics</topic><topic>Aluminum - pharmacology</topic><topic>Animals</topic><topic>Body Weight - drug effects</topic><topic>Copper - blood</topic><topic>Copper - metabolism</topic><topic>Deferiprone</topic><topic>Manganese - blood</topic><topic>Manganese - metabolism</topic><topic>Pyridones - pharmacology</topic><topic>Rabbits</topic><topic>Spectrum Analysis</topic><topic>Trace elements</topic><topic>Zinc - blood</topic><topic>Zinc - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Ping</creatorcontrib><creatorcontrib>Yao, Yu-Na</creatorcontrib><creatorcontrib>Wu, Shi-De</creatorcontrib><creatorcontrib>Dong, Huai-Jun</creatorcontrib><creatorcontrib>Feng, Guo-Chang</creatorcontrib><creatorcontrib>Yuan, Xiao-Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Ping</au><au>Yao, Yu-Na</au><au>Wu, Shi-De</au><au>Dong, Huai-Jun</au><au>Feng, Guo-Chang</au><au>Yuan, Xiao-Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2005-08-01</date><risdate>2005</risdate><volume>99</volume><issue>8</issue><spage>1733</spage><epage>1737</epage><pages>1733-1737</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>The effect of 1,2-dimethyl-3-hydroxypyrid-4-one [deferiprone (DE)] on aluminum mobilization and elimination from tissues and serum as well as the influence on the excretion of trace elements, copper, zinc and manganese in rabbits was investigated. Sixteen New Zealand rabbits were randomly divided into three groups: control, Al-only and Al
+
DE. The Al-only and Al
+
DE animals received injections of Al
2(SO
4)
3
·
18H
2O 600
μmol Al/kg 5 days per week for 3 weeks. One week after the last Al injection the Al
+
DE rabbits were given deferiprone 750
μmol/kg/day intragastrically for 2 weeks. At the 42nd day the animals were sacrificed and the organs were taken and digested. Blood was taken from the ear artery three times (at the initiation of the experiment, before and after deferiprone administration). The aluminum and copper, zinc, manganese were determined by atomic absorption spectrophotometry. Our results showed that deferiprone could highly mobilize aluminum stores from tissues. At the end of experiment the aluminum contents of bone, kidney, liver and brain in Al
+
DE were significantly lower than that in Al-only rabbits. The copper, zinc, manganese contents were not affected by deferiprone administration.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>16045992</pmid><doi>10.1016/j.jinorgbio.2005.06.002</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of inorganic biochemistry, 2005-08, Vol.99 (8), p.1733-1737 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aluminum Aluminum - administration & dosage Aluminum - blood Aluminum - pharmacokinetics Aluminum - pharmacology Animals Body Weight - drug effects Copper - blood Copper - metabolism Deferiprone Manganese - blood Manganese - metabolism Pyridones - pharmacology Rabbits Spectrum Analysis Trace elements Zinc - blood Zinc - metabolism |
| title | The efficacy of deferiprone on tissues aluminum removal and copper, zinc, manganese level in rabbits |
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