Tumor necrosis factor-alpha: Alternative role as an inhibitor of osteoclast formation in vitro

TNFα is known to stimulate the development and activity of osteoclasts and of bone resorption. The cytokine was found to mediate bone loss in conjunction with inflammatory diseases such as rheumatoid arthritis or chronic aseptic inflammation induced by wear particles from implants and was suggested...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2006-08, Vol.39 (2), p.325-335
Hauptverfasser:	Balga, Renate, Wetterwald, Antoinette, Portenier, Jeannette, Dolder, Silvia, Mueller, Christoph, Hofstetter, Willy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Bone Marrow Cells - cytology Bone Resorption - metabolism Carrier Proteins - pharmacology Cells, Cultured Coculture Techniques Culture Media, Conditioned - chemistry Dexamethasone - pharmacology Dose-Response Relationship, Drug Glucocorticoid Glycoproteins - analysis Inflammation Macrophage Colony-Stimulating Factor - pharmacology Membrane Glycoproteins - pharmacology Mice Mice, Inbred C57BL Mice, Mutant Strains Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteoclast Osteoclasts - cytology Osteoclasts - drug effects Osteoclasts - metabolism Osteoprotegerin RANK Ligand Receptor Activator of Nuclear Factor-kappa B Receptors, Cytoplasmic and Nuclear - analysis Receptors, Tumor Necrosis Factor - analysis Resorption Spleen - cytology Steroid Hydroxylases - pharmacology TNFα Tumor Necrosis Factor-alpha - analysis Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - deficiency Tumor Necrosis Factor-alpha - pharmacology
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