Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE
Endometriosis is a gynaecological disorder characterized by the presence and growth of endometrial tissue in ectopic sites. In this study we examined the immunological functions of patients with endometriosis and serum level of PCBs and p, p′-DDE to verify the impact of these environmental contamina...
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| Veröffentlicht in: | Life sciences (1973) 2006-06, Vol.79 (5), p.491-498 |
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| creator | Quaranta, Maria Giovanna Porpora, Maria Grazia Mattioli, Benedetta Giordani, Luciana Libri, Irene Ingelido, Anna Maria Cerenzia, Pierangelo Di Felice, Alessia Abballe, Annalisa De Felip, Elena Viora, Marina |
| description | Endometriosis is a gynaecological disorder characterized by the presence and growth of endometrial tissue in ectopic sites. In this study we examined the immunological functions of patients with endometriosis and serum level of PCBs and
p,
p′-DDE to verify the impact of these environmental contaminants on the dysregulation of immune functions. We found that proliferative responses and immunoglobulin production were not dysregulated in patients with endometriosis while NK cell activity was significantly down-regulated in these patients. Moreover, a significant down-regulation of IL-1β and IL-12 production was found in patients with respect to controls. Serum levels of PCBs and
p,
p′-DDE were found to be significantly higher in women with endometriosis than in the control group, with respect to the sum of the congeners most prominent in human tissues. In particular, total PCBs concentration in patients with endometriosis and controls was respectively 330 and 160 ng/g fat with respect to the most abundant congeners, while
p,
p′-DDE concentration was of 770 and 310 ng/g fat. Moreover, we found that normal human PBMC pulsed with PCBs,
p,
p′-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1β and IL-12 production. These findings suggest that changes in specific immune parameters correlate with elevated serum PCBs and DDE levels and endometriosis. |
| doi_str_mv | 10.1016/j.lfs.2006.01.026 |
| format | Article |
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p,
p′-DDE to verify the impact of these environmental contaminants on the dysregulation of immune functions. We found that proliferative responses and immunoglobulin production were not dysregulated in patients with endometriosis while NK cell activity was significantly down-regulated in these patients. Moreover, a significant down-regulation of IL-1β and IL-12 production was found in patients with respect to controls. Serum levels of PCBs and
p,
p′-DDE were found to be significantly higher in women with endometriosis than in the control group, with respect to the sum of the congeners most prominent in human tissues. In particular, total PCBs concentration in patients with endometriosis and controls was respectively 330 and 160 ng/g fat with respect to the most abundant congeners, while
p,
p′-DDE concentration was of 770 and 310 ng/g fat. Moreover, we found that normal human PBMC pulsed with PCBs,
p,
p′-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1β and IL-12 production. These findings suggest that changes in specific immune parameters correlate with elevated serum PCBs and DDE levels and endometriosis.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2006.01.026</identifier><identifier>PMID: 16499933</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Case-Control Studies ; Cell Proliferation - drug effects ; Concanavalin A - pharmacology ; Cytokines - biosynthesis ; Cytokines - immunology ; Cytotoxicity, Immunologic - drug effects ; Cytotoxicity, Immunologic - immunology ; DDE ; Dichlorodiphenyl Dichloroethylene - blood ; Dichlorodiphenyl Dichloroethylene - pharmacology ; Endometriosis ; Endometriosis - immunology ; Female ; Humans ; IL-12 ; IL-1β ; Immunoglobulin production ; Immunoglobulins - biosynthesis ; K562 Cells ; Killer Cells, Natural - immunology ; Middle Aged ; NK-cell-mediated cytotoxic activity ; PBMC ; PCBs ; Pokeweed Mitogens - pharmacology ; Polychlorinated Biphenyls - blood ; Polychlorinated Biphenyls - pharmacology ; Proliferative response</subject><ispartof>Life sciences (1973), 2006-06, Vol.79 (5), p.491-498</ispartof><rights>2006 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-f3222b4a9f53ceb9bdb41857d4b334272a6e85dc40e20f9e0fb61d8fd227505c3</citedby><cites>FETCH-LOGICAL-c351t-f3222b4a9f53ceb9bdb41857d4b334272a6e85dc40e20f9e0fb61d8fd227505c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lfs.2006.01.026$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16499933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Quaranta, Maria Giovanna</creatorcontrib><creatorcontrib>Porpora, Maria Grazia</creatorcontrib><creatorcontrib>Mattioli, Benedetta</creatorcontrib><creatorcontrib>Giordani, Luciana</creatorcontrib><creatorcontrib>Libri, Irene</creatorcontrib><creatorcontrib>Ingelido, Anna Maria</creatorcontrib><creatorcontrib>Cerenzia, Pierangelo</creatorcontrib><creatorcontrib>Di Felice, Alessia</creatorcontrib><creatorcontrib>Abballe, Annalisa</creatorcontrib><creatorcontrib>De Felip, Elena</creatorcontrib><creatorcontrib>Viora, Marina</creatorcontrib><title>Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Endometriosis is a gynaecological disorder characterized by the presence and growth of endometrial tissue in ectopic sites. In this study we examined the immunological functions of patients with endometriosis and serum level of PCBs and
p,
p′-DDE to verify the impact of these environmental contaminants on the dysregulation of immune functions. We found that proliferative responses and immunoglobulin production were not dysregulated in patients with endometriosis while NK cell activity was significantly down-regulated in these patients. Moreover, a significant down-regulation of IL-1β and IL-12 production was found in patients with respect to controls. Serum levels of PCBs and
p,
p′-DDE were found to be significantly higher in women with endometriosis than in the control group, with respect to the sum of the congeners most prominent in human tissues. In particular, total PCBs concentration in patients with endometriosis and controls was respectively 330 and 160 ng/g fat with respect to the most abundant congeners, while
p,
p′-DDE concentration was of 770 and 310 ng/g fat. Moreover, we found that normal human PBMC pulsed with PCBs,
p,
p′-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1β and IL-12 production. These findings suggest that changes in specific immune parameters correlate with elevated serum PCBs and DDE levels and endometriosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Cell Proliferation - drug effects</subject><subject>Concanavalin A - pharmacology</subject><subject>Cytokines - biosynthesis</subject><subject>Cytokines - immunology</subject><subject>Cytotoxicity, Immunologic - drug effects</subject><subject>Cytotoxicity, Immunologic - immunology</subject><subject>DDE</subject><subject>Dichlorodiphenyl Dichloroethylene - blood</subject><subject>Dichlorodiphenyl Dichloroethylene - pharmacology</subject><subject>Endometriosis</subject><subject>Endometriosis - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>IL-12</subject><subject>IL-1β</subject><subject>Immunoglobulin production</subject><subject>Immunoglobulins - biosynthesis</subject><subject>K562 Cells</subject><subject>Killer Cells, Natural - immunology</subject><subject>Middle Aged</subject><subject>NK-cell-mediated cytotoxic activity</subject><subject>PBMC</subject><subject>PCBs</subject><subject>Pokeweed Mitogens - pharmacology</subject><subject>Polychlorinated Biphenyls - blood</subject><subject>Polychlorinated Biphenyls - pharmacology</subject><subject>Proliferative response</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1uFDEQhS0EIkPgAGyQV-y6U7b7F1bJJCRRImABa8ttl4WH7nZjewJzAO6NJzMSu2yqpKpXT68-Qt4yKBmw5mxTjjaWHKApgZXAm2dkxbq2L6AR7DlZAfCqEBzqE_Iqxg0A1HUrXpIT1lR93wuxIn9vp0W5gIZ-vis0jmMxoXEq5YHeJZ_8H6ep0sk9uLSjaj6Mf7oZ6RK82eaNn6mb6aKSwzlF-tulHxRn4ydMwfno4gd6ThcfoxtGpMHnYn2gX9cX8dHw8vLqNXlh1RjxzbGfku-frr6tb4r7L9e36_P7QouapcIKzvlQqd7WQuPQD2aoWFe3phqEqHjLVYNdbXQFyMH2CHZomOms4bytodbilLw_-Obsv7YYk5xc3H-tZvTbKJsOur5lTRayg1CHHDyglUtwkwo7yUDu2cuNzOzlnr0EJjP7fPPuaL4dMsT_F0fYWfDxIMD84oPDIKPOzHQGHlAnabx7wv4fORiWaA</recordid><startdate>20060627</startdate><enddate>20060627</enddate><creator>Quaranta, Maria Giovanna</creator><creator>Porpora, Maria Grazia</creator><creator>Mattioli, Benedetta</creator><creator>Giordani, Luciana</creator><creator>Libri, Irene</creator><creator>Ingelido, Anna Maria</creator><creator>Cerenzia, Pierangelo</creator><creator>Di Felice, Alessia</creator><creator>Abballe, Annalisa</creator><creator>De Felip, Elena</creator><creator>Viora, Marina</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060627</creationdate><title>Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE</title><author>Quaranta, Maria Giovanna ; Porpora, Maria Grazia ; Mattioli, Benedetta ; Giordani, Luciana ; Libri, Irene ; Ingelido, Anna Maria ; Cerenzia, Pierangelo ; Di Felice, Alessia ; Abballe, Annalisa ; De Felip, Elena ; Viora, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-f3222b4a9f53ceb9bdb41857d4b334272a6e85dc40e20f9e0fb61d8fd227505c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Cell Proliferation - drug effects</topic><topic>Concanavalin A - pharmacology</topic><topic>Cytokines - biosynthesis</topic><topic>Cytokines - immunology</topic><topic>Cytotoxicity, Immunologic - drug effects</topic><topic>Cytotoxicity, Immunologic - immunology</topic><topic>DDE</topic><topic>Dichlorodiphenyl Dichloroethylene - blood</topic><topic>Dichlorodiphenyl Dichloroethylene - pharmacology</topic><topic>Endometriosis</topic><topic>Endometriosis - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>IL-12</topic><topic>IL-1β</topic><topic>Immunoglobulin production</topic><topic>Immunoglobulins - biosynthesis</topic><topic>K562 Cells</topic><topic>Killer Cells, Natural - immunology</topic><topic>Middle Aged</topic><topic>NK-cell-mediated cytotoxic activity</topic><topic>PBMC</topic><topic>PCBs</topic><topic>Pokeweed Mitogens - pharmacology</topic><topic>Polychlorinated Biphenyls - blood</topic><topic>Polychlorinated Biphenyls - pharmacology</topic><topic>Proliferative response</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Quaranta, Maria Giovanna</creatorcontrib><creatorcontrib>Porpora, Maria Grazia</creatorcontrib><creatorcontrib>Mattioli, Benedetta</creatorcontrib><creatorcontrib>Giordani, Luciana</creatorcontrib><creatorcontrib>Libri, Irene</creatorcontrib><creatorcontrib>Ingelido, Anna Maria</creatorcontrib><creatorcontrib>Cerenzia, Pierangelo</creatorcontrib><creatorcontrib>Di Felice, Alessia</creatorcontrib><creatorcontrib>Abballe, Annalisa</creatorcontrib><creatorcontrib>De Felip, Elena</creatorcontrib><creatorcontrib>Viora, Marina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Quaranta, Maria Giovanna</au><au>Porpora, Maria Grazia</au><au>Mattioli, Benedetta</au><au>Giordani, Luciana</au><au>Libri, Irene</au><au>Ingelido, Anna Maria</au><au>Cerenzia, Pierangelo</au><au>Di Felice, Alessia</au><au>Abballe, Annalisa</au><au>De Felip, Elena</au><au>Viora, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>2006-06-27</date><risdate>2006</risdate><volume>79</volume><issue>5</issue><spage>491</spage><epage>498</epage><pages>491-498</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Endometriosis is a gynaecological disorder characterized by the presence and growth of endometrial tissue in ectopic sites. In this study we examined the immunological functions of patients with endometriosis and serum level of PCBs and
p,
p′-DDE to verify the impact of these environmental contaminants on the dysregulation of immune functions. We found that proliferative responses and immunoglobulin production were not dysregulated in patients with endometriosis while NK cell activity was significantly down-regulated in these patients. Moreover, a significant down-regulation of IL-1β and IL-12 production was found in patients with respect to controls. Serum levels of PCBs and
p,
p′-DDE were found to be significantly higher in women with endometriosis than in the control group, with respect to the sum of the congeners most prominent in human tissues. In particular, total PCBs concentration in patients with endometriosis and controls was respectively 330 and 160 ng/g fat with respect to the most abundant congeners, while
p,
p′-DDE concentration was of 770 and 310 ng/g fat. Moreover, we found that normal human PBMC pulsed with PCBs,
p,
p′-DDE and their combination showed a significant down-regulation of NK cell cytotoxic activity and IL-1β and IL-12 production. These findings suggest that changes in specific immune parameters correlate with elevated serum PCBs and DDE levels and endometriosis.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>16499933</pmid><doi>10.1016/j.lfs.2006.01.026</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2006-06, Vol.79 (5), p.491-498 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Adolescent Adult Case-Control Studies Cell Proliferation - drug effects Concanavalin A - pharmacology Cytokines - biosynthesis Cytokines - immunology Cytotoxicity, Immunologic - drug effects Cytotoxicity, Immunologic - immunology DDE Dichlorodiphenyl Dichloroethylene - blood Dichlorodiphenyl Dichloroethylene - pharmacology Endometriosis Endometriosis - immunology Female Humans IL-12 IL-1β Immunoglobulin production Immunoglobulins - biosynthesis K562 Cells Killer Cells, Natural - immunology Middle Aged NK-cell-mediated cytotoxic activity PBMC PCBs Pokeweed Mitogens - pharmacology Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - pharmacology Proliferative response |
| title | Impaired NK-cell-mediated cytotoxic activity and cytokine production in patients with endometriosis: A possible role for PCBs and DDE |
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