Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells

The Bmi-1 oncoprotein regulates proliferation and oncogenesis in human cells. Its overexpression leads to senescence bypass in human fibroblasts and immortalization of human mammary epithelial cells. In this study, we report that compared with normal nasopharyngeal epithelial cells (NPEC), Bmi-1 is...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-06, Vol.66 (12), p.6225-6232
Hauptverfasser:	SONG, Li-Bing, ZENG, Mu-Sheng, FU, Li-Wu, HUANG, Wen-Lin, DIMRI, Goberdhan P, BAND, Vimla, ZENG, Yi-Xin, LIAO, Wen-Ting, LING ZHANG, MO, Hao-Yuan, LIU, Wan-Li, SHAO, Jian-Yong, WU, Qiu-Liang, LI, Man-Zhi, XIA, Yun-Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Biological and medical sciences Biomarkers, Tumor - biosynthesis Biomarkers, Tumor - genetics Cell Line, Tumor Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis Cyclin-Dependent Kinase Inhibitor p16 - genetics Disease Progression DNA Damage Down-Regulation Epithelial Cells - enzymology Epithelial Cells - metabolism Female Humans Immunohistochemistry Male Medical sciences Middle Aged Nasopharyngeal Neoplasms - enzymology Nasopharyngeal Neoplasms - genetics Nasopharyngeal Neoplasms - metabolism Nasopharyngeal Neoplasms - pathology Neoplasm Staging Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Otorhinolaryngology. Stomatology Pharmacology. Drug treatments Polycomb Repressive Complex 1 Prognosis Proto-Oncogene Proteins - biosynthesis Proto-Oncogene Proteins - genetics Repressor Proteins - biosynthesis Repressor Proteins - genetics RNA, Messenger - biosynthesis RNA, Messenger - genetics Telomerase - metabolism Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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